Neurotransmitter Function: Changes Associated with in Utero Alcohol Exposure

2022 ◽  
pp. 171-189
Author(s):  
Mary Druse Manteuffel
Keyword(s):  
Alcohol Exposure ◽  
In Utero

scholarly journals Alcohol Exposure in Utero Increases Susceptibility to Prostate Tumorigenesis in Rat Offspring

2013 ◽  
Vol 37 (11) ◽  
pp. 1901-1909 ◽  
Author(s):  
Sengottuvelan Murugan ◽  
Changqing Zhang ◽  
Sepideh Mojtahedzadeh ◽  
Dipak K. Sarkar
Keyword(s):  
Alcohol Exposure ◽  
In Utero ◽  
Prostate Tumorigenesis ◽  
Rat Offspring

N-Methyl-D-aspartate subunit expression during mouse development altered by in utero alcohol exposure

2005 ◽  
Vol 193 (4) ◽  
pp. 1534-1539 ◽  
Author(s):  
Laura Toso ◽  
Sarah H. Poggi ◽  
Daniel Abebe ◽  
Robin Roberson ◽  
Veronica Dunlap ◽  
...  
Keyword(s):  
Alcohol Exposure ◽  
In Utero ◽  
Mouse Development ◽  
Subunit Expression

PGR - 3 Adapting Neuropsychological Evaluation for a Complex Pediatric Patient with Challenging Behaviors

2019 ◽  
Vol 34 (6) ◽  
pp. 829-829
Author(s):  
D McEachern ◽  
M Steed
Keyword(s):  
Stimulant Medication ◽  
Neurodevelopmental Disorder ◽  
Challenging Behaviors ◽  
Alcohol Exposure ◽  
In Utero ◽  
Neuropsychological Evaluation ◽  
Prenatal Substance Exposure ◽  
Oppositional Defiant ◽  
State Psychiatric ◽  
Early Trauma

Abstract Objective The detrimental impact of in utero substance use on developing fetuses manifests well into adolescence (Wu, Ju, & Lu, 2011; Minnes, Lang, & Singer, 2011). Likewise, the effects of early childhood neglect during critical developmental periods may be long lasting (de Bellis, et al., 2009; Hildyard & Wolfe, 2002). Factors such as these may require creative adaptation of assessment. This case illustrates the process of evaluating a child presenting with an unusual developmental history and extremely challenging behaviors and describes efforts to maintain engagement while eliciting valid data. Successful and unsuccessful interventions will be reviewed. Method Patient is a 12-year-old Caucasian male admitted to a state psychiatric hospital with a complex presentation of emotional, behavioral, and cognitive difficulties. Aggravating factors consist of likely in utero drug and alcohol exposure, early trauma, chronic neglect, and unusually small physical stature. Neuropsychological evaluation was completed over the course of five days. Testing sessions were brief, on a unit where no one was present, and were structured using both intermittent and scheduled reinforcement to maintain effort and engagement. Results Testing indicated significant and consistent weaknesses in executive functioning, learning, memory, and attention. Despite the use of stimulant medication, difficulty with vigilance, sustained attention, and impulsivity persisted. Diagnoses were Neurodevelopmental Disorder associated with prenatal substance exposure, Generalized Anxiety Disorder, Attention Deficit/Hyperactivity Disorder, Combined presentation, and Oppositional Defiant Disorder, Moderate. Conclusions Unconventional history warrants unconventional approach to assessment. Recommendations included not only approaches to improving his attention, but just as important, strategies to elicit his best performance in various settings.

Alcohol Exposure In Utero Leads to Enhanced Prepubertal Mammary Development and Alterations in Mammary IGF and Estradiol Systems

2011 ◽  
Vol 2 (4) ◽  
pp. 239-248 ◽  
Author(s):  
Tiffany A. Polanco ◽  
Catina Crismale-Gann ◽  
Wendie S. Cohick
Keyword(s):  
Alcohol Exposure ◽  
In Utero ◽  
Mammary Development

Abstract 537: Alcohol exposure in utero induces histophysiological changes in prostate and increases susceptibility to prostate tumorigenesis in rat offspring

2012 ◽  
Author(s):  
Sengottuvelan Murugan ◽  
Changqing Zhang ◽  
Sepideh Mojtahedzaadeh ◽  
Kenneth Reuhl ◽  
Dipak K. Sarkar
Keyword(s):  
Alcohol Exposure ◽  
In Utero ◽  
Prostate Tumorigenesis ◽  
Rat Offspring

scholarly journals Alcohol exposure in utero disrupts cortico-striatal coordination required for behavioral flexibility

2020 ◽  
Vol 162 ◽  
pp. 107832 ◽  
Author(s):  
Kristin Marquardt ◽  
James F. Cavanagh ◽  
Jonathan L. Brigman
Keyword(s):  
Behavioral Flexibility ◽  
Alcohol Exposure ◽  
In Utero

Alcohol brain NMDA subunit expression altered by in utero alcohol exposure

2004 ◽  
Vol 191 (6) ◽  
pp. S130
Author(s):  
Laura Toso ◽  
Sarah Poggi ◽  
Jane Park ◽  
Veronica Dunlap ◽  
Robin Roberson ◽  
...  
Keyword(s):  
Alcohol Exposure ◽  
In Utero ◽  
Subunit Expression

Making Research More Ethical for Adults with Fetal Alcohol Spectrum Disorder

2019 ◽  
pp. 173-184
Author(s):  
John Aspler
Keyword(s):  
Focus Group ◽  
Fetal Alcohol Spectrum Disorder ◽  
Alcohol Exposure ◽  
In Utero ◽  
Spectrum Disorder ◽  
Fetal Alcohol ◽  
Focus Group Interviews ◽  
Focus Group Study ◽  
Group Interviews ◽  
Fetal Alcohol Spectrum

In this chapter, the author reflects on challenges associated with conducting focus group interviews with adults with fetal alcohol spectrum disorder (FASD)—a complex neurodevelopmental disability caused by alcohol exposure in utero. Given the heterogeneity of this diagnosis, people with FASD have different strengths and weaknesses. Therefore, for effective and ethical research inclusion, each person with FASD may need unique accommodations, which can help to both minimize concerns about unjust research exclusion and mitigate sources of vulnerability. To explore these issues, the author describes the focus group study, presents anticipated risks and challenges, explores critical stakeholder feedback, and addresses ethical tensions arising from the resulting protocol adjustments. This chapter demonstrates the importance of researchers remaining open to criticism and being willing to work through their moral discomfort.

scholarly journals A Longitudinal Study of the Long-Term Consequences of Drinking during Pregnancy: Heavy In Utero Alcohol Exposure Disrupts the Normal Processes of Brain Development

2012 ◽  
Vol 32 (44) ◽  
pp. 15243-15251 ◽  
Author(s):  
C. Lebel ◽  
S. N. Mattson ◽  
E. P. Riley ◽  
K. L. Jones ◽  
C. M. Adnams ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Brain Development ◽  
Alcohol Exposure ◽  
In Utero ◽  
Long Term Consequences
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