Applications and comparisons of spatial predictive methods

2022 ◽  
pp. 305-350
Author(s):  
Jin Li
Keyword(s):  
2009 ◽  
Vol 30 (1) ◽  
pp. 319-332 ◽  
Author(s):  
James A. Toombs ◽  
Blake R. McCarty ◽  
Eric D. Ross

ABSTRACT Numerous prions (infectious proteins) have been identified in yeast that result from the conversion of soluble proteins into β-sheet-rich amyloid-like protein aggregates. Yeast prion formation is driven primarily by amino acid composition. However, yeast prion domains are generally lacking in the bulky hydrophobic residues most strongly associated with amyloid formation and are instead enriched in glutamines and asparagines. Glutamine/asparagine-rich domains are thought to be involved in both disease-related and beneficial amyloid formation. These domains are overrepresented in eukaryotic genomes, but predictive methods have not yet been developed to efficiently distinguish between prion and nonprion glutamine/asparagine-rich domains. We have developed a novel in vivo assay to quantitatively assess how composition affects prion formation. Using our results, we have defined the compositional features that promote prion formation, allowing us to accurately distinguish between glutamine/asparagine-rich domains that can form prion-like aggregates and those that cannot. Additionally, our results explain why traditional amyloid prediction algorithms fail to accurately predict amyloid formation by the glutamine/asparagine-rich yeast prion domains.


Author(s):  
Denis D. Rickman ◽  
Donald W. Murrell ◽  
Byron J. Armstrong
Keyword(s):  

2021 ◽  
Vol 2 (2) ◽  
pp. 191-223
Author(s):  
Rebecca Robinson

Abstract The Document on Rain (Yushu 雨書) is a short manuscript that forms part of the Beijing University collection of Han slips. This text, divided into two sections, has thus far garnered little scholarly attention. However, it presents to us an unusual example of a daybook (rishu 日書)-type manuscript, one which is primarily concerned with the weather. The Document on Rain, while sharing many characteristics of excavated daybooks, is unusual in its treatment of humans. Rather than providing advice on whether or not one should undertake activity on a certain day or engaging in the discourse about whether or not humans can manipulate the weather, the Document on Rain represents an understanding of the weather as a phenomenon that cannot be manipulated by humans, but one which can, perhaps, be understood. The Document on Rain integrates practices of prognostication based on calendrical and sexagenary cycles with theories about rain and its relationship to the symbolic characteristics of the twenty-eight lodges (ershiba xiu 二十八宿). This article analyses some of the predictive methods in the text and situates it within a longer tradition of meteoromantic practices.


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