Self-Emulsifying Drug Delivery Systems: A Strategy to Improve the Bioavailability of Hydrophobic Drugs

2021 ◽  
pp. 129-164
Author(s):  
Ankita Banerjee ◽  
Rajesh Kumar ◽  
Monica Gulati ◽  
Sachin Kumar Singh ◽  
Kamal Dua ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydrophobic Drugs

Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

2013 ◽  
pp. 151-197 ◽  
Author(s):  
Naveed Ahmed ◽  
C.E. Mora-Huertas ◽  
Chiraz Jaafar-Maalej ◽  
Hatem Fessi ◽  
Abdelhamid Elaissari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug ◽  
Polymeric Drug Delivery Systems

Triglycerol-based hyperbranched polyesters with an amphiphilic branched shell as novel biodegradable drug delivery systems

2016 ◽  
Vol 7 (4) ◽  
pp. 887-898 ◽  
Author(s):  
Stefano Stefani ◽  
Indah N. Kurniasih ◽  
Sunil K. Sharma ◽  
Christoph Böttcher ◽  
Paul Servin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Hyperbranched Polyester ◽  
Hydrophobic Drugs ◽  
Hyperbranched Polyesters ◽  
Biodegradable Drug Delivery Systems

A set of biodegradable nanocarriers characterized by a hyperbranched polyester core and an amphiphilic branched shell was developed and employed to efficiently solubilize hydrophobic drugs in aqueous media.

Phenylboronic acid-incorporated elastin-like polypeptide nanoparticle drug delivery systems

2017 ◽  
Vol 8 (13) ◽  
pp. 2105-2114 ◽  
Author(s):  
Weizhi Chen ◽  
Shilu Ji ◽  
Xiaoping Qian ◽  
Yajun Zhang ◽  
Cheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Effect ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Specific Accumulation ◽  
Nanoparticle Drug Delivery

Packaging hydrophobic drugs into nanoparticles can improve their aqueous solubility, tumor-specific accumulation and therapeutic effect.

Liposomes as Vancomycin Hydrochloride Delivery System

2021 ◽  
Vol 903 ◽  
pp. 3-8
Author(s):  
Mārīte Skrinda ◽  
Arita Dubnika ◽  
Janis Locs
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Encapsulation Efficiency ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Free Drug ◽  
Hydrophobic Drugs ◽  
Vancomycin Hydrochloride

Liposomes are being used as unique drug delivery systems due to their ability to encapsulate both hydrophilic and hydrophobic drugs, as well as for the fact that they improve the disadvantages of free drug administration. However, liposomes have a significant disadvantage - low encapsulation efficiency. In the research carried out, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol (Chol), in the ratio (n/n) of 2:1, 3:1 and 4:1 respectively, were used to prepare the liposomes. Blank liposomes (LIP) and vancomycin hydrochloride (VANKA) containing liposomes (VANKA-LIP) were prepared for each of the DSPC and Chol compositions. The aim of our study was to evaluate the effect of liposome composition on the VANKA encapsulation efficiency and release kinetics.

Self Nano Emulsifying Drug Delivery Systems for Oral Delivery of Hydrophobic Drugs

2013 ◽  
Vol 6 (2) ◽  
pp. 355-362 ◽  
Author(s):  
Udaya Sakthi M. ◽  
Josephine Ritashinita Lobo F. ◽  
Kiran B. Uppuluri
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydrophobic Drugs

scholarly journals A REVIEW ON CURRENT STATUS OF SELF-EMULSIFYING DRUG DELIVERY SYSTEMS

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
R. Nagaraju ◽  
Damineni Saritha ◽  
P. Subhash Chandra Bose ◽  
G. Ravi ◽  
Valluru Ravi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Current Status ◽  
Hydrophobic Drugs ◽  
Related Information ◽  
Main Challenge ◽  
Drug Compounds ◽  
Gentle Agitation

The modern drug delivery system of hydrophobic drugs presents a main challenge because of the poor aqueous solubility of such compounds. Self emulsifying drug delivery systems (SEDDS) are usually used to enhance the bioavailability of hydrophobic drugs. SEDDS can be administered orally in soft or hard gelatin capsules and form fine relatively stable oil in water (o/w) emulsions upon aqueous dilution due to the gentle agitation of the gastrointestinal fluids. From time to time so many workers have claimed different rational applications of Self-emulsifying formulation for increcing bioavailability and site-specific targeting of highly lipophilic drugs. Significant improvement in the oral bioavailability of these drug compounds has been demonstrated for each case. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SEDDS will continue, and more drug compounds formulated as SEDDS will reach the pharmaceutical market in the future. The present article gives an overview of the Composition, mechanism, advantages, disadvantages, characterization, recent advancements, patents related information of SEEDS and commercial products approved for oral transmucosal administration.

Hydrogel-based ocular drug delivery systems for hydrophobic drugs

2020 ◽  
Vol 154 ◽  
pp. 105503 ◽  
Author(s):  
Cesar Torres-Luna ◽  
Xin Fan ◽  
Roman Domszy ◽  
Naiping Hu ◽  
Nam Sun Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Hydrophobic Drugs

Polymeric micelles as drug delivery vehicles

RSC Advances ◽  
2014 ◽  
Vol 4 (33) ◽  
pp. 17028-17038 ◽  
Author(s):  
Zaheer Ahmad ◽  
Afzal Shah ◽  
Muhammad Siddiq ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Made In

Though much progress has been made in drug delivery systems, the design of a suitable carrier for the delivery of hydrophobic drugs is still a major challenge for researchers.

Sign in / Sign up

Export Citation Format

Share Document