Oligonucleotide Conjugates in Antisense Technology

2020 ◽  
pp. 399-477
Keyword(s):  
Antisense Technology ◽  
Oligonucleotide Conjugates

scholarly journals Novel Lipid-Oligonucleotide Conjugates Containing Long-Chain Sulfonyl Phosphoramidate Groups: Synthesis and Biological Properties

2021 ◽  
Vol 11 (3) ◽  
pp. 1174
Author(s):  
Alina Derzhalova ◽  
Oleg Markov ◽  
Alesya Fokina ◽  
Yasuo Shiohama ◽  
Timofei Zatsepin ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Biological Properties ◽  
Dna And Rna ◽  
Guidance Molecules ◽  
Low Cytotoxicity ◽  
Oligonucleotide Conjugates ◽  
Long Chain

New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3′ or 5′-end were synthesized and characterized. Low cytotoxicity of the conjugates and their ability to be taken up into cells without transfection agents were demonstrated. Lipid-conjugated siRNAs targeting repulsive guidance molecules a (RGMa) have shown a comparable gene silencing activity in PK-59 cells to unmodified control siRNA when delivered into the cells via Lipofectamine mediated transfection.

Antisense Technology

2003 ◽  
pp. 10-1-10-19
Author(s):  
S Patrick Walton ◽  
Charles Roth ◽  
Martin Yarmush
Keyword(s):  
Antisense Technology

scholarly journals Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids

2018 ◽  
Vol 13 ◽  
pp. 483-492 ◽  
Author(s):  
Marc Nothisen ◽  
Phanélie Perche-Létuvée ◽  
Jean-Paul Behr ◽  
Jean-Serge Remy ◽  
Mitsuharu Kotera
Keyword(s):  
Carrier Free ◽  
Oligonucleotide Conjugates

scholarly journals Protein/oligonucleotide conjugates as a cell specific PNA carrier

2001 ◽  
Vol 1 (1) ◽  
pp. 217-218 ◽  
Author(s):  
K. Obara ◽  
T. Ishihara ◽  
T. Akaike ◽  
A. Maruyama
Keyword(s):  
A Cell ◽  
Oligonucleotide Conjugates

PHOTOSENSITIZED AND CATALYTIC OXIDATION OF DNA BY METALLOPHTHALOCYANINE-OLIGONUCLEOTIDE CONJUGATES

2001 ◽  
Vol 20 (4-7) ◽  
pp. 1259-1262 ◽  
Author(s):  
V. V. Koval ◽  
A. A. Chernonosov ◽  
T. V. Abramova ◽  
T. M. Ivanova ◽  
O. S. Fedorova ◽  
...  
Keyword(s):  
Catalytic Oxidation ◽  
Oxidation Of Dna ◽  
Oligonucleotide Conjugates
Sign in / Sign up

Export Citation Format

Share Document