Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure

2006 ◽  
pp. 73-100 ◽  
Author(s):  
Deborah Rice
Keyword(s):  
Cognitive Impairment ◽  
Animal Models ◽  
Lead Exposure

Animal Models of Down Syndrome

2021 ◽  
Author(s):  
Anna J. Moyer ◽  
Roger H. Reeves
Keyword(s):  
Down Syndrome ◽  
Cognitive Impairment ◽  
Intellectual Disability ◽  
Animal Models ◽  
Brain Regions ◽  
Laboratory Mice ◽  
Tremendous Progress ◽  
New Treatments ◽  
And Function ◽  
Early Developmental

Is intellectual disability a treatable feature of persons with Down syndrome? Researchers have made tremendous progress in the last 30 years, from creating the first mouse model of Down syndrome to completing the first major clinical trial for cognitive impairment in people with Down syndrome. Until recently, normalizing brain development and function seemed too lofty a goal, and indeed, even proposing a candidate therapy requires answering a number of difficult questions. How does trisomy 21, a molecular diagnosis, cause the clinical phenotypes of Down syndrome? When, where, and how do trisomic genes act to disrupt normal development and which genes are involved with which outcomes? Which brain regions and behaviors are most impaired? Is there an early developmental window of time during which treatments are most effective? This article discusses how animal models such as laboratory mice can be used to understand intellectual disability and to develop new treatments for cognitive impairment.

Cognitive impairment associated with chronic lead exposure in adults

2018 ◽  
Vol 30 ◽  
pp. 5-8 ◽  
Author(s):  
Mohammad Taghi Mansouri ◽  
Isabel Muñoz-Fambuena ◽  
Omar Cauli
Keyword(s):  
Cognitive Impairment ◽  
Lead Exposure ◽  
Chronic Lead Exposure

scholarly journals ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia

2014 ◽  
Vol 24 (10) ◽  
pp. 1698-1708 ◽  
Author(s):  
Mayako Yamazaki ◽  
Katsuya Harada ◽  
Noriyuki Yamamoto ◽  
Junko Yarimizu ◽  
Mayuko Okabe ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Animal Models ◽  
Receptor Antagonist ◽  
Positive Symptoms

Behavioral effects of moderate lead exposure in children and animal models: Part 1, clinical studies

1980 ◽  
Vol 8 (1) ◽  
pp. 43-99 ◽  
Author(s):  
Robert Bornschein ◽  
Douglas Pearson ◽  
Lawrence Reiter ◽  
Lester D. Grant
Keyword(s):  
Animal Models ◽  
Lead Exposure ◽  
Clinical Studies ◽  
Behavioral Effects

Effect Modification By Cognition-Related Polymorphisms Of The Association Between Cumulative Lead Exposure And Incident Cognitive Impairment In Older Men

2015 ◽  
Vol 2015 (1) ◽  
pp. 2748
Author(s):  
Zishaan Ahmed Farooqui ◽  
Kelly Bakulski ◽  
Patricia Cassano ◽  
David Sparrow ◽  
Avron Spiro Iii ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Lead Exposure ◽  
Older Men ◽  
Effect Modification

scholarly journals Improving Effects of Platycodon Extracts Jelly on β-amyloid-induced Cytotoxicity and Scopolamine-Induced Cognitive Impairment Animal Models

2013 ◽  
Vol 26 (4) ◽  
pp. 417-425 ◽  
Author(s):  
Hong-Geun Oh ◽  
Jung-Hoon Kim ◽  
Eun-Hye Shin ◽  
Young-Rye Kang ◽  
Bong-Gun Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Animal Models ◽  
Β Amyloid
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