Mapping the Genes for the Acoustic Startle Response (ASR) and Prepulse Inhibition of the ASR in the BXD Recombinant Inbred Series: Effect of High-Frequency Hearing Loss and Cochlear Pathology

2001 ◽  
pp. 455-470
Keyword(s):  
Hearing Loss ◽  
Prepulse Inhibition ◽  
Recombinant Inbred ◽  
High Frequency ◽  
Startle Response ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
High Frequency Hearing Loss ◽  
Cochlear Pathology

Caudal Pontine Reticular Formation of C57BL/6J Mice: Responses to Startle Stimuli, Inhibition by Tones, and Plasticity

1998 ◽  
Vol 79 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Stephanie Carlson ◽  
James F. Willott
Keyword(s):  
Hearing Loss ◽  
Reticular Formation ◽  
Auditory System ◽  
Neural Plasticity ◽  
High Frequency ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Pontine Reticular Formation ◽  
High Frequency Hearing Loss ◽  
Old Mice

Carlson, Stephanie and James F. Willott. Caudal pontine reticular formation of C57BL/6J mice: responses to startle stimuli, inhibition by tones, and plasticity. J. Neurophysiol. 79: 2603–2614, 1998. C57BL/6J (C57) mice were used to examine relationships between the behavioral acoustic startle response (ASR) and the responses of neurons in the caudal pontine reticular formation (PnC) in three contexts: 1) responses evoked by basic startle stimuli; 2) the prepulse inhibition (PPI) paradigm; and 3) the effects of high-frequency hearing loss and concomitant neural plasticity that occurs in middle-aged C57 mice. 1) Responses (evoked action potentials) of PnC neurons closely paralleled the ASR with respect to latency, threshold, and responses to rapidly presented stimuli. 2) “Neural PPI” (inhibition of responses evoked by a startle stimulus when preceded by a tone prepulse) was observed in all PnC neurons studied. 3) In PnC neurons of 6-mo-old mice with high-frequency (>20 kHz) hearing loss, neural PPI was enhanced with 12- and 4-kHz prepulses, as it is behaviorally. These are frequencies that have become “overrepresented” in the central auditory system of 6-mo-old C57 mice. Thus neural plasticity in the auditory system, induced by high-frequency hearing loss, is correlated with increased salience of the inhibiting tones in both behavioral and neural PPI paradigms.

Structural brain correlates of prepulse inhibition of the acoustic startle response in healthy humans

NeuroImage ◽  
2005 ◽  
Vol 26 (4) ◽  
pp. 1052-1058 ◽  
Author(s):  
Veena Kumari ◽  
Elena Antonova ◽  
Elizabeth Zachariah ◽  
Adrian Galea ◽  
Ingrid Aasen ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Startle Response ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Healthy Humans ◽  
Brain Correlates ◽  
Structural Brain

Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats

2006 ◽  
Vol 87 (5) ◽  
pp. 917-924 ◽  
Author(s):  
Maggie S. Burhans ◽  
Catherine Dailey ◽  
Jason Wiesinger ◽  
Laura E. Murray-Kolb ◽  
Byron C. Jones ◽  
...  
Keyword(s):  
Young Adult ◽  
Iron Deficiency ◽  
Prepulse Inhibition ◽  
Startle Response ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Adult Rats
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