NASAL HYPERREACTIVITY

Positional rhinomanometry is a physiologic method for estimating nasal resistance, which is variable, difficult to predict, and linked to vasomotor activity of the functional system culminating in the turbinate valves. Thirty subjects suffering from allergic rhinitis, 25 patients affected by aspecific rhinitis, and 40 healthy controls underwent positional rhinomanometry. Test positions included the seated (baseline), supine, and recumbent (homolateral and contralateral to the nasal fossa under examination). In patients with perennial allergic rhinitis and in those with aspecific rhinitis, positional rhinomanometry elicited two pathologic responses: either an average percentage rise of more than 80% in nasal resistance in the supine and homolateral and contralateral recumbent positions compared with basal values, or a paradoxical fall in the supine and homolateral recumbent positions.

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Pathophysiology of Nasal Hyperreactivity

American Journal of Rhinology ◽

10.2500/105065893782172484 ◽

1993 ◽

Vol 7 (4) ◽

pp. 207-207

Author(s):

P. van Cauwenberg

Keyword(s):

Nasal Hyperreactivity

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Alterations of neuroreceptors in nasal hyperreactivity.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1990.tb05494.x ◽

1990 ◽

Vol 30 (S1) ◽

pp. 162S-164S

Author(s):

YJ Megen ◽

JF Rodrigues de Miranda ◽

AB Klaassen

Keyword(s):

Nasal Hyperreactivity

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Nasal Hyperreactivity and Allergic Inflammation in Nasal Allergy

Practica oto-rhino-laryngologica Suppl ◽

10.5631/jibirinsuppl1986.1992.supplement57_38 ◽

1992 ◽

Vol 1992 (Supplement57) ◽

pp. 38-45

Author(s):

Akiyoshi Konno ◽

Eiko Ito ◽

Nobuhisa Terada

Keyword(s):

Allergic Inflammation ◽

Nasal Allergy ◽

Nasal Hyperreactivity

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Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls

Clinical & Experimental Allergy ◽

10.1111/j.1365-2222.1996.tb00625.x ◽

1996 ◽

Vol 26 (8) ◽

pp. 903-908 ◽

Cited By ~ 12

Author(s):

C. DE GRAAF-INT VELD ◽

I. M. GARRELDS ◽

S. KOENDERS ◽

R. GERTH VAN WIJK

Keyword(s):

Allergic Rhinitis ◽

Perennial Allergic Rhinitis ◽

Nasal Hyperreactivity

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One Year follow-up of Patients with Rhinitis Medicamentosa after Vasoconstrictor Withdrawal

American Journal of Rhinology ◽

10.2500/105065897781446865 ◽

1997 ◽

Vol 11 (1) ◽

pp. 67-72 ◽

Cited By ~ 5

Author(s):

Peter M. Graf ◽

Hans Hallén

Keyword(s):

Nasal Spray ◽

Nasal Mucosa ◽

Adequate Treatment ◽

Nasal Stuffiness ◽

Symptom Scores ◽

Nasal Hyperreactivity ◽

One Year ◽

Rhinitis Medicamentosa

The aim of the study was to systematically follow-up 10 patients with rhinitis medicamentosa for at least 1 year after vasoconstrictor withdrawal. During withdrawal of the decongestants the patients used budesonide nasal spray, 400 μg/day, for 6 weeks. The thickness of the nasal mucosa, the decongestive effect of oxymetazoline, and the histamine sensitivity were measured with rhinostereometry during the period. The thickness of the nasal mucosa and the symptom scores of nasal stuffiness were reduced considerably 6 and 12 months after vasoconstrictor withdrawal. The histamine sensitivity reflecting nasal hyperreactivity was still increased after 6 months, but not after 1 year. The decongestive effect of oxymetazoline increased after 6 months, indicating reversible tolerance. We conclude that when given adequate treatment and information about nose-drop overuse, all patients were able to stop using the vasoconstrictors and no one relapsed into a daily long-term overuse of vasoconstrictors during the 1-year follow-up period.

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