PURPURA FULMINANS

Wound Healing ◽  
2005 ◽  
pp. 303-303
Keyword(s):  
Purpura Fulminans

Purpura Fulminans in a Patient Homozygous for a Mutation in the Protein C Gene - Prenatal Diagnosis in a Subsequent Pregnancy

1996 ◽  
Vol 75 (03) ◽  
pp. 525-526 ◽  
Author(s):  
M C Alessi ◽  
M F Aillaud ◽  
O Paut ◽  
B Roquelaure ◽  
M Alhenc-Gelas ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Protein C ◽  
Purpura Fulminans ◽  
Subsequent Pregnancy

Severe Homozygous Protein C Deficiency: Identification of a Splice Site Missense Mutation (184, Q → H) in Exon 7 of the Protein C Gene

1994 ◽  
Vol 72 (01) ◽  
pp. 065-069 ◽  
Author(s):  
J M Soria ◽  
D Brito ◽  
J Barceló ◽  
J Fontcuberta ◽  
L Botero ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Gene Product ◽  
Splice Site ◽  
Protein C ◽  
Purpura Fulminans ◽  
Single Strand Conformation Polymorphism ◽  
Donor Splice Site ◽  
Protein C Deficiency ◽  
Donor Splice ◽  
Newborn Child

SummarySingle strand conformation polymorphism (SSCP) analysis of exon 7 of the protein C gene has identified a novel splice site missense mutation (184, Q → H), in a newborn child with purpura fulminans and undetectable protein C levels. The mutation, seen in the homozygous state in the child and in the heterozygous state in her mother, was characterized and found to be a G to C nucleotide substitution at the -1 position of the donor splice site of intron 7 of the protein C gene, which changes histidine 184 for glutamine (184, Q → H). According to analysis of the normal and mutated sequences, this mutation should also abolish the function of the donor splice site of intron 7 of the protein C gene. Since such a mutation is compatible with the absence of gene product in plasma and since DNA sequencing of all protein C gene exons in this patient did not reveal any other mutation, we postulate that mutation 184, Q → H results in the absence of protein C gene product in plasma, which could be the cause of the severe phenotype observed in this patient.

Purpura fulminans skin lesions in a newborn with complete protein C deficiency

1998 ◽  
Vol 132 (3) ◽  
pp. 558 ◽  
Author(s):  
Gideon Paret ◽  
Asher Barzilai ◽  
Zohar Barzilay
Keyword(s):  
Protein C ◽  
Purpura Fulminans ◽  
Skin Lesions ◽  
Protein C Deficiency ◽  
Complete Protein

Purpura fulminans due to protein S deficiency following chickenpox

1992 ◽  
Vol 127 (1) ◽  
pp. 30-32 ◽  
Author(s):  
W.G. PHILLIPS ◽  
J.R. MARSDEN ◽  
F.G. HILL
Keyword(s):  
Purpura Fulminans ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency

Vibrio vulnificusSepticemia Presenting as Purpura Fulminans

2005 ◽  
Vol 32 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Hye-Jin Choi ◽  
Dong-Kyung Lee ◽  
Mi-Woo Lee ◽  
Jee-Ho Choi ◽  
Kee-Chan Moon ◽  
...  
Keyword(s):  
Purpura Fulminans

Outbreak ofNeisseria meningitidisC in workers at a large food-processing plant in Brazil: challenges of controlling disease spread to the larger community

2011 ◽  
Vol 140 (5) ◽  
pp. 906-915 ◽  
Author(s):  
B. P. M. ISER ◽  
H. C. A. V. LIMA ◽  
C. De MORAES ◽  
R. P. A. De ALMEIDA ◽  
L. T. WATANABE ◽  
...  
Keyword(s):  
Food Processing ◽  
Purpura Fulminans ◽  
Control Measures ◽  
Disease Spread ◽  
Processing Plant ◽  
Sterile Site ◽  
Matched Case ◽  
Epidemiological Link ◽  
Control Study ◽  
Food Processing Plant

SUMMARYAn outbreak of meningococcal disease (MD) with severe morbidity and mortality was investigated in midwestern Brazil in order to identify control measures. A MD case was defined as isolation ofNeisseria meningitidis, or detection of polysaccharide antigen in a sterile site, or presence of clinical purpura fulminans, or an epidemiological link with a laboratory-confirmed case-patient, between June and August 2008. In 8 out of 16 MD cases studied, serogroup C ST103 complex was identified. Five (31%) cases had neurological findings and five (31%) died. The attack rate was 12 cases/100 000 town residents and 60 cases/100 000 employees in a large local food-processing plant. We conducted a matched case-control study of eight primary laboratory-confirmed cases (1:4). Factors associated with illness in single variable analysis were work at the processing plant [matched odds ratio (mOR) 22, 95% confidence interval (CI) 2·3–207·7,P<0·01], and residing <1 year in Rio Verde (mOR 7, 95% CI 1·11–43·9,P<0·02). Mass vaccination (>10 000 plant employees) stopped propagation in the plant, but not in the larger community.

scholarly journals Varicella-Associated Purpura Fulminans: Chicken Pox Is Not Always Benign

2006 ◽  
Vol 15 (3) ◽  
pp. 232-234 ◽  
Author(s):  
A. Abdulmalik ◽  
W. Al-Ateeqi ◽  
M. Al-Khawari ◽  
S. Al-Osaimi
Keyword(s):  
Purpura Fulminans ◽  
Chicken Pox
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