The Epidermal Permeability Barrier: From Saran Wrap to Biosensor

Skin Barrier ◽  
2005 ◽  
pp. 45-52 ◽  
Keyword(s):  
Permeability Barrier ◽  
Epidermal Permeability Barrier ◽  
Saran Wrap

Beneficial effect of curcumin on epidermal permeability barrier function

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
HY Jeon ◽  
JK Kim ◽  
JE Lee ◽  
WG Kim ◽  
SJ Lee
Keyword(s):  
Beneficial Effect ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Epidermal Permeability Barrier

Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice

2021 ◽  
pp. 1-7
Author(s):  
Shota Sakai ◽  
Asami Makino ◽  
Akihito Nishi ◽  
Takeshi Ichikawa ◽  
Tadashi Yamashita ◽  
...  
Keyword(s):  
Plasma Membranes ◽  
Lamellar Body ◽  
Lipid Mediator ◽  
Permeability Barrier ◽  
Compensatory Mechanisms ◽  
Terrestrial Environment ◽  
Sphingomyelin Synthase ◽  
Epidermal Permeability Barrier ◽  
Deficient Mice

Sphingomyelin (SM) is a constituent of cellular membranes, while ceramides (Cer) produced from SM on plasma membranes serve as a lipid mediator that regulates cell proliferation, differentiation, and apoptosis. In the skin, SM also is a precursor of Cer, an important constituent of epidermal permeability barrier. We investigated the role of epidermal SM synthase (SMS)2, an isoform of SMS, which modulates SM and Cer levels on plasma membranes. Although SMS2-knockout (SMS2-KO) mice were not neonatal lethal, an ichthyotic phenotype with epidermal hyperplasia and hyperkeratosis was evident at birth, which persisted until 2 weeks of age. These mice showed abnormal lamellar body morphology and secretion, and abnormal extracellular lamellar membranes in the stratum corneum. These abnormalities were no longer evident by 4 weeks of age in SMS2-KO mice. Our study suggests that (1) exposure to a dry terrestrial environment initiates compensatory responses, thereby normalizing epidermal ichthyotic abnormalities and (2) that a nonlethal gene abnormality can cause an ichthyotic skin phenotype.

scholarly journals Epidermal Permeability Barrier Recovery Is Delayed in Vitiligo-Involved Sites

2010 ◽  
Vol 23 (4) ◽  
pp. 193-200 ◽  
Author(s):  
J. Liu ◽  
W.Y. Man ◽  
C.Z. Lv ◽  
S.P. Song ◽  
Y.J. Shi ◽  
...  
Keyword(s):  
Permeability Barrier ◽  
Epidermal Permeability Barrier

scholarly journals Ontogeny of the Epidermal Permeability Barrier

1998 ◽  
Vol 3 (2) ◽  
pp. 75-79 ◽  
Author(s):  
Mary L. Williams ◽  
Karen Hanley ◽  
Peter M. Elias ◽  
Kenneth R. Feingold
Keyword(s):  
Permeability Barrier ◽  
Epidermal Permeability Barrier
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