Psychological stress has the potential to cause a decline in the epidermal permeability barrier function of the horny layer

2014 ◽  
Vol 37 (1) ◽  
pp. 63-69 ◽  
Author(s):  
S. Fukuda ◽  
S. Baba ◽  
T. Akasaka
Keyword(s):  
Psychological Stress ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Horny Layer ◽  
Epidermal Permeability Barrier

Beneficial effect of curcumin on epidermal permeability barrier function

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
HY Jeon ◽  
JK Kim ◽  
JE Lee ◽  
WG Kim ◽  
SJ Lee
Keyword(s):  
Beneficial Effect ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Epidermal Permeability Barrier

Stress alters cutaneous permeability barrier homeostasis

2000 ◽  
Vol 278 (2) ◽  
pp. R367-R372 ◽  
Author(s):  
Mitsuhiro Denda ◽  
Toru Tsuchiya ◽  
Peter M. Elias ◽  
Kenneth R. Feingold
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Antagonist ◽  
Psychological Stress ◽  
Skin Disease ◽  
Barrier Function ◽  
Plasma Corticosterone ◽  
Permeability Barrier ◽  
Hairless Mice ◽  
Ru 486 ◽  
Kinetics Of

Recent studies have shown that psychological stress can influence cutaneous barrier function, suggesting that this form of stress could trigger or aggravate skin disease. In the present study, we demonstrate that transfer of hairless mice to a different cage delays barrier recovery rates. Pretreatment with a phenothiazine sedative, chlorpromazine, before transfer of animals restored the kinetics of barrier recovery toward normal, suggesting that psychological stress is the basis for this alteration in barrier homeostasis. To determine the mechanism linking psychological stress to altered barrier recovery, we first demonstrated that plasma corticosterone levels increase markedly after transfer of animals to new cages and that pretreatment with chlorpromazine blocks this increase. Second, we demonstrated that the systemic administration of corticosterone delays barrier recovery. Finally, we demonstrated that pretreatment with the glucocorticoid receptor antagonist RU-486 blocks the delay in barrier recovery produced by systemic corticosterone, change of cage, or immobilization. These results suggest that psychological stress stimulates increased production of glucocorticoids, which, in turn, adversely affects permeability barrier homeostasis.

scholarly journals A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin

2011 ◽  
Vol 20 (3) ◽  
pp. 285-288 ◽  
Author(s):  
Mona Man ◽  
Melanie Hupe ◽  
Donald Mackenzie ◽  
Hyunjung Kim ◽  
Yuko Oda ◽  
...  
Keyword(s):  
Barrier Function ◽  
Permeability Barrier ◽  
Herbal Mixture ◽  
Chinese Herbal ◽  
Epidermal Permeability Barrier

scholarly journals Fatty acids are required for epidermal permeability barrier function.

1993 ◽  
Vol 92 (2) ◽  
pp. 791-798 ◽  
Author(s):  
M Mao-Qiang ◽  
P M Elias ◽  
K R Feingold
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Epidermal Permeability Barrier

scholarly journals Herbal medicines that benefit epidermal permeability barrier function

2015 ◽  
Vol 33 (2) ◽  
pp. 90-95 ◽  
Author(s):  
Lizhi Hu ◽  
Huibin Man ◽  
Peter M. Elias ◽  
Mao-Qiang Man
Keyword(s):  
Barrier Function ◽  
Herbal Medicines ◽  
Permeability Barrier ◽  
Epidermal Permeability Barrier
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