Chiral Electrochemical Sensors Based on Molecularly Imprinted Polymers with Pharmaceutical Applications

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

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Pharmaceutical applications for molecularly imprinted polymers

International Journal of Pharmaceutics ◽

10.1016/s0378-5173(99)00355-5 ◽

2000 ◽

Vol 195 (1-2) ◽

pp. 39-43 ◽

Cited By ~ 115

Author(s):

C.J Allender ◽

C Richardson ◽

B Woodhouse ◽

C.M Heard ◽

K.R Brain

Keyword(s):

Molecularly Imprinted Polymers ◽

Molecularly Imprinted ◽

Imprinted Polymers ◽

Pharmaceutical Applications

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MOLECULARLY IMPRINTED POLYMER NANOPARTICLES (MIP-NPs) APPLICATIONS IN ELECTROCHEMICAL SENSORS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i6.35088 ◽

2019 ◽

pp. 1-6

Author(s):

DIANE FAUZI ◽

FEBRINA AMELIA SAPUTRI

Keyword(s):

Molecularly Imprinted Polymers ◽

High Stability ◽

Electrochemical Sensors ◽

Specific Binding ◽

Environmental Contaminants ◽

Polymer Nanoparticles ◽

Selective Recognition ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Imprinted Polymers

Molecularly Imprinted Polymers (MIPs) is a polymer that binds together to form a specific binding site that is selective for certain analytes. Its high stability, its synthesize simplicity, and it can ease costs significantly make it was applied widely as a receptor instead of antibodies or enzymes. MIPs can be re-developed into MIPs nanoparticles (MIP-NPs) which have greater potential. MIPs use in electrochemical sensors have relevant applications in daily life and have been tested in human samples. Electrochemical sensors have been successfully functioned with MIP-NPs leading to real-time monitoring of drugs, pesticides, environmental contaminants, and secondary metabolites, as well as molecules with biological relevance. The aim of this review is to summarize the developments and applications of MIP-NPs as a selective recognition component in electrochemical sensors with special emphasis on their analytical applications.

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