scholarly journals The Effect of THAM and Sodium Bicarbonate on the Oxygen Dissociation Curve and pH Difference Across the Red Cell

1968 ◽  
Vol 2 (3) ◽  
pp. 193-197 ◽  
Author(s):  
F C Battaglia ◽  
E L Makowski ◽  
G Meschia ◽  
M M Niernberg
Keyword(s):  
Sodium Bicarbonate ◽  
Red Cell ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation

Red-cell 2,3-diphosphoglycerate in patients with hyperthyroidism

1980 ◽  
Vol 93 (4) ◽  
pp. 424-429 ◽  
Author(s):  
J. L. Alvarez-Sala ◽  
M. A. Urbán ◽  
J. J. Sicilia ◽  
A. J. Diaz Fdez ◽  
F. Fdez Mendieta ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Control Group ◽  
Red Cell ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation ◽  
The Right ◽  
Serum Thyroid Hormones ◽  
Hyperthyroid Patients ◽  
2,3 Dpg

Abstract. In 21 hyperthyroid female patients studied on 29 occasions, high levels of red-cell 2,3-diphosphoglycerate (2,3-DPG) have been found (5.75 ± 0.7 mm) which, compared to a euthyroid control group (4.88 ± 0.4 mm), could not be accounted for by differences in haematocrit, haemoglobin or phosphataemia. A significant correlation was found (P < 0.05) between serum thyroid hormones and the 2,3-DPG concentration in the hyperthyroid patients. Eight of these patients were reexamined after treatment and normalization of thyroid function, showed a regression to normal 2,3-DPG values (4.81 ± 0.6 mm) which could not be attributed to variations in haematocrit, haemoglobin or phosphataemia either. We therefore deduce that the shift to the right in the haemoglobin oxygen dissociation curve observed in patients of this type may be due to an increase in the red-cell 2,3-DPG content.

The Bohr effect related to blood and erythrocyte pH

1963 ◽  
Vol 205 (2) ◽  
pp. 337-340 ◽  
Author(s):  
Peter Hilpert ◽  
Renate Gislinde Fleischmann ◽  
Doris Kempe ◽  
Heinz Bartels
Keyword(s):  
Oxygen Pressure ◽  
Ph Value ◽  
Oxygen Affinity ◽  
Bohr Effect ◽  
Red Cell ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation ◽  
Constant Cell ◽  
The Right

The Bohr effect of the blood and the red cell hemolysates of adult and newborn humans, goats and kids, and sheep and lambs were determined and the physiological significance is discussed. Similar determinations were made on blood from an African elephant, yak, camel, Dybowski deer, and llama. The strong displacement to the right of the oxygen dissociation curve which occurs in kids and lambs during the first 5 days of life can be largely explained by a change in the pH value within the erythrocytes. When the oxygen affinity is expressed by the oxygen pressure necessary for half saturation (T50) at a constant cell pH, considerable differences exist between species.

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