Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the α4β2 nicotinic acetylcholine receptor subtype using nonlinear techniques

Joshua T. Ayers; Aaron Clauset; Jeffrey D. Schmitt; Linda P. Dwoskin; Peter A. Crooks

doi:10.1208/aapsj070368

Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the α4β2 nicotinic acetylcholine receptor subtype using nonlinear techniques

The AAPS Journal ◽

10.1208/aapsj070368 ◽

2005 ◽

Vol 7 (3) ◽

pp. E678-E685 ◽

Cited By ~ 9

Author(s):

Joshua T. Ayers ◽

Aaron Clauset ◽

Jeffrey D. Schmitt ◽

Linda P. Dwoskin ◽

Peter A. Crooks

Keyword(s):

Molecular Modeling ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Quaternary Ammonium ◽

Quaternary Ammonium Salts ◽

Ammonium Salts ◽

Receptor Subtype ◽

Nicotinic Acetylcholine

Molecular modeling of the α9α10 nicotinic acetylcholine receptor subtype

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.10.094 ◽

2009 ◽

Vol 19 (1) ◽

pp. 251-254 ◽

Cited By ~ 20

Author(s):

Edwin G. Pérez ◽

Bruce K. Cassels ◽

Gerald Zapata-Torres

Keyword(s):

Molecular Modeling ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Subtype ◽

Nicotinic Acetylcholine

Faculty Opinions recommendation of A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1147992.605097 ◽

2009 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

High Sensitivity ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Amyloid Peptides ◽

Basal Forebrain Cholinergic Neurons

Faculty Opinions recommendation of A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1147992.1706087 ◽

2010 ◽

Author(s):

Mark A Smith ◽

Sonia Correia

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

High Sensitivity ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Amyloid Peptides ◽

Basal Forebrain Cholinergic Neurons

QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.12.036 ◽

2006 ◽

Vol 14 (9) ◽

pp. 3017-3037 ◽

Cited By ~ 44

Author(s):

Fang Zheng ◽

Ersin Bayram ◽

Sangeetha P. Sumithran ◽

Joshua T. Ayers ◽

Chang-Guo Zhan ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Quaternary Ammonium ◽

Acetylcholine Receptors ◽

Dopamine Release ◽

Quaternary Ammonium Salts ◽

Ammonium Salts ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Qsar Modeling ◽

Nicotinic Acetylcholine

A Novel Nicotinic Acetylcholine Receptor Subtype in Basal Forebrain Cholinergic Neurons with High Sensitivity to Amyloid Peptides

Journal of Neuroscience ◽

10.1523/jneurosci.3952-08.2009 ◽

2009 ◽

Vol 29 (4) ◽

pp. 918-929 ◽

Cited By ~ 112

Author(s):

Q. Liu ◽

Y. Huang ◽

F. Xue ◽

A. Simard ◽

J. DeChon ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

High Sensitivity ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Amyloid Peptides ◽

Basal Forebrain Cholinergic Neurons

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b00115 ◽

2018 ◽

Vol 61 (10) ◽

pp. 4628-4634 ◽

Cited By ~ 14

Author(s):

Rilei Yu ◽

Han-Shen Tae ◽

Nargis Tabassum ◽

Juan Shi ◽

Tao Jiang ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Molecular Determinants ◽

Dependent Activity

The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse

Neuropharmacology ◽

10.1016/j.neuropharm.2013.01.017 ◽

2013 ◽

Vol 70 ◽

pp. 228-235 ◽

Cited By ~ 42

Author(s):

Kia J. Jackson ◽

Sarah S. Sanjakdar ◽

Pretal P. Muldoon ◽

J. Michael McIntosh ◽

M. Imad Damaj

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotine Withdrawal ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Withdrawal Signs

Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.10.015 ◽

2018 ◽

Vol 160 ◽

pp. 207-228 ◽

Cited By ~ 2

Author(s):

Marta Quadri ◽

Almin Silnović ◽

Carlo Matera ◽

Nicole A. Horenstein ◽

Clare Stokes ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Subtype ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics

Biophysical Journal ◽

10.1016/s0006-3495(96)79370-0 ◽

1996 ◽

Vol 71 (4) ◽

pp. 1659-1671 ◽

Cited By ~ 48

Author(s):

R. Sankararamakrishnan ◽

C. Adcock ◽

M.S. Sansom

Keyword(s):

Molecular Modeling ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Pore Domain

Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

Frontiers in Cellular Neuroscience ◽

10.3389/fncel.2017.00336 ◽

2017 ◽

Vol 11 ◽

Cited By ~ 8

Author(s):

Li-Chi Huang ◽

Ching-Ling Lin ◽

Jia-Zheng Qiu ◽

Chun-Yu Lin ◽

Kai-Wen Hsu ◽

...

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Pulmonary Metastasis ◽

Triple Negative ◽

Receptor Subtype ◽

Breast Cancers ◽

Nicotinic Acetylcholine