10. A 47-year-old Man with Ultimobranchial Body Remnants (Solid Cell Nests) and Hashimoto Thyroiditis

2013 ◽  
pp. 40-43
Author(s):  
B. Biondi ◽  
C. Bellevicine ◽  
S. Ippolito ◽  
D. Arpaia ◽  
G. Troncone
Keyword(s):  
Hashimoto Thyroiditis ◽  
Ultimobranchial Body ◽  
Solid Cell Nests ◽  
Solid Cell

Thyroid Adenoma of Probable Ultimobranchial Body Origin: A Case Report

2020 ◽  
pp. 106689692094644
Author(s):  
K. K. W. Yuen ◽  
A. N. H. Chan ◽  
J. K. C. Chan ◽  
W. Cheuk
Keyword(s):  
Adipose Tissue ◽  
Thyroid Tumor ◽  
Left Lobe ◽  
Thyroid Adenoma ◽  
Large Tumor ◽  
Ultimobranchial Body ◽  
Solid Cell Nests ◽  
Galectin 3 ◽  
Myxoid Matrix ◽  
Solid Cell

Solid cell nests are generally believed to represent remnants of the ultimobranchial body, which can be found in the normal thyroid gland, occasionally associated with other branchial pouch remnants such as salivary gland, cartilage, and adipose tissue. We describe the case of a 44-year-old man incidentally found to have a large tumor in the left lobe of the thyroid. The tumor was a circumscribed growth consisting of distinctly lobulated proliferation of solid to cystic epidermoid cell nests and thyroid follicles in a fibromatous stroma, which merged into abundant adipose tissue and focally myxoid matrix. The solid epidermoid cell nests resembled solid cell nests and exhibited a p63+, GATA3+, galectin-3+, TTF1−, PAX8−, thyroglobulin− phenotypes, while the follicles were p63−, GATA3−, galectin-3−, TTF1+, PAX8+, and thyroglobulin+. RAS mutations were not found. This thyroid tumor may represent a hitherto undescribed “ultimobranchial body adenoma” in human.

scholarly journals Ultimobranchial Body Remnants (Solid Cell Nests) as a Pitfall in Thyroid Pathology

2012 ◽  
Vol 97 (7) ◽  
pp. 2209-2210 ◽  
Author(s):  
C. Bellevicine ◽  
S. Ippolito ◽  
D. Arpaia ◽  
G. Ciancia ◽  
G. Pettinato ◽  
...  
Keyword(s):  
Ultimobranchial Body ◽  
Thyroid Pathology ◽  
Solid Cell Nests ◽  
Solid Cell

Solid Cell Nests Hyperplasia (Ultimobranchial Body Remnants) of the Thyroid: A Pitfall

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S51-S51
Author(s):  
H Bharadwaj ◽  
A Khan
Keyword(s):  
Follicular Adenoma ◽  
Immunohistochemical Analysis ◽  
Hashimoto Thyroiditis ◽  
Follicular Neoplasm ◽  
Transitional Epithelium ◽  
Risk Category ◽  
Cell Hyperplasia ◽  
Diagnostic Dilemma ◽  
Solid Cell Nests ◽  
Solid Cell

Abstract Introduction/Objective Solid cell nests (SCN) are small epithelial cell nests interspersed within thyroid parenchyma, resembling squamous/transitional epithelium. SCNs, which are ultimobranchial remnants, are popularly considered pluripotent stem-cells responsible for developing follicular and C-cells. While SCNs are not an uncommon incidental findings in thyroid, solid cell nest hyperplasia is rare. SCNs are often mistaken for benign entities such as C-cell hyperplasia (CCH) or malignant lesions such as papillary thyroid carcinoma (PTC), metastatic squamous cell carcinoma, or medullary thyroid microcarcinoma (MTC). Methods/Case Report To reiterate this diagnostic dilemma, we present a case of a 57-year-old male with a six-year history of Hashimoto thyroiditis and multiple bilateral thyroid nodules. Ultrasonography revealed two nodules, one in each lobe, measuring 2.0x1.9x1.8cm(right) and 1.6x1.5x1.5cm(left). Both were solid, hypoechoic nodules with smooth margins and no echogenic foci. Fine-needle aspiration of right nodule was suspicious for follicular neoplasm, Hürthle- cell type, and the left nodule was atypia of unknown significance. Right-hemithyroidectomy specimen revealed follicular adenoma and oncocytic adenomatous nodules in a background of florid lymphocytic thyroiditis (Hashimoto). In two blocks, small solid nests of cells were identified, largest focus measuring 0.5 cm. The cells were polygonal to epithelioid with moderate amphophilic cytoplasm. Nuclei were centrally located, irregular to oval with occasional grooves. While nests had a squamoid appearance, they did not have intercellular bridges. Although nuclear grooves and evenly dispersed chromatin and chromocenters were noted, they lacked optical clearing or intra-nuclear inclusions characteristic for PTC. Thus, excluding these two possibilities, primary diagnostic considerations were SCN versus CCH. Immunohistochemical analysis showed cells positive for P63 and CK5/6 and negative for PAX-8, TTF-1, thyroglobulin, CEA, and calcitonin. Results (if a Case Study enter NA) NA Conclusion If wrongly diagnosed as CCH, patients may be placed in a high-risk category for possible development of MTC. It is, thus, necessary to be aware of SCN, which can occasionally become hyperplastic, to prevent misdiagnosis.

scholarly journals Solid Cell Nests Within a Parathyroid Gland—Report of an Exceptional Case

2018 ◽  
Vol 29 (4) ◽  
pp. 365-368
Author(s):  
C. Christofer Juhlin ◽  
Inga-Lena Nilsson ◽  
Anders Höög
Keyword(s):  
Parathyroid Gland ◽  
Exceptional Case ◽  
Solid Cell Nests ◽  
Solid Cell

Solid Cell Nests: Role in Thyroid Disease

2007 ◽  
Vol 14 (2) ◽  
pp. 141-142
Author(s):  
Mohammed Akhtar ◽  
Theresa Scognamiglio
Keyword(s):  
Thyroid Disease ◽  
Solid Cell Nests ◽  
Solid Cell
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