Thyroid Adenoma of Probable Ultimobranchial Body Origin: A Case Report

2020 ◽  
pp. 106689692094644
Author(s):  
K. K. W. Yuen ◽  
A. N. H. Chan ◽  
J. K. C. Chan ◽  
W. Cheuk
Keyword(s):  
Adipose Tissue ◽  
Thyroid Tumor ◽  
Left Lobe ◽  
Thyroid Adenoma ◽  
Large Tumor ◽  
Ultimobranchial Body ◽  
Solid Cell Nests ◽  
Galectin 3 ◽  
Myxoid Matrix ◽  
Solid Cell

Solid cell nests are generally believed to represent remnants of the ultimobranchial body, which can be found in the normal thyroid gland, occasionally associated with other branchial pouch remnants such as salivary gland, cartilage, and adipose tissue. We describe the case of a 44-year-old man incidentally found to have a large tumor in the left lobe of the thyroid. The tumor was a circumscribed growth consisting of distinctly lobulated proliferation of solid to cystic epidermoid cell nests and thyroid follicles in a fibromatous stroma, which merged into abundant adipose tissue and focally myxoid matrix. The solid epidermoid cell nests resembled solid cell nests and exhibited a p63+, GATA3+, galectin-3+, TTF1−, PAX8−, thyroglobulin− phenotypes, while the follicles were p63−, GATA3−, galectin-3−, TTF1+, PAX8+, and thyroglobulin+. RAS mutations were not found. This thyroid tumor may represent a hitherto undescribed “ultimobranchial body adenoma” in human.

scholarly journals Ultimobranchial Body Remnants (Solid Cell Nests) as a Pitfall in Thyroid Pathology

2012 ◽  
Vol 97 (7) ◽  
pp. 2209-2210 ◽  
Author(s):  
C. Bellevicine ◽  
S. Ippolito ◽  
D. Arpaia ◽  
G. Ciancia ◽  
G. Pettinato ◽  
...  
Keyword(s):  
Ultimobranchial Body ◽  
Thyroid Pathology ◽  
Solid Cell Nests ◽  
Solid Cell

scholarly journals A Case Report: A Third/Fourth Branchial Pouch Anomaly Presented by Solid Thyroid and Lateral Cervical Neck Masses

2016 ◽  
Vol 9 ◽  
pp. CPath.S31734 ◽  
Author(s):  
Magda H. A. Nasreldin ◽  
Eman A. Ibrahim ◽  
Somaia A. Saad El-Din
Keyword(s):  
Rare Case ◽  
Histopathological Examination ◽  
Parathyroid Tissue ◽  
Thyroid Tumor ◽  
Cervical Lymph Nodes ◽  
Neck Masses ◽  
Malignant Thyroid Tumor ◽  
Branchial Arches ◽  
Thyroid Swelling ◽  
Solid Cell

Branchial pouch-derived anomalies may arise from remnants of the first, second, or third/fourth branchial arches. Branchial pouch-related structures are found within the thyroid gland in the form of solid cell rests, epithelial lined cyst with or without an associated lymphoid component, thymic and/or parathyroid tissue, and less commonly in the form of heterotopic cartilage. We present a rare case of left solid thyroid swelling nearby two cervical nodules in a seven-year-old female with a clinical diagnosis suggestive of malignant thyroid tumor with metastasis to the cervical lymph nodes. Histopathological examination revealed that it was compatible with third/fourth branchial pouch-derived anomaly composed of mature cartilage and thymic and parathyroid tissues for clinical and radiological correlations.

scholarly journals Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Shihan Zhen ◽  
Ruoxin Cai ◽  
Xuelian Yang ◽  
Yanan Ma ◽  
Deliang Wen
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Adipose Tissue ◽  
Binding Protein ◽  
Adult Population ◽  
Biological Marker ◽  
Immunofluorescent Staining ◽  
Enzyme Linked Immunosorbent Assay ◽  
Regression Analyses ◽  
Galectin 3

BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological marker for metabolic syndrome (MetS).MethodsThe biochemical and anthropometric variables of the 570 participants in this study were evaluated using standard procedures. Their serum GAL-3BP levels were measured using enzyme-linked immunosorbent assay (ELISA), while the association between the glycoprotein and MetS was analyzed using multiple logistic regression analyses. Moreover, an experimental MetS model was established. The expression of GAL-3BP in serum and adipose tissue was measured using ELISA and western blotting. Lipid accumulation was determined with the use of immunohistochemistry and immunofluorescent staining.ResultsThe serum GAL-3BP level was found to be positively associated with MetS. The logistic regression analyses demonstrated that participants expressing the upper levels of GAL-3BP were more likely to develop MetS than those expressing less of the glycoprotein (OR = 2.39, 95%CI: 1.49, 3.83). The association between the serum GAL-3BP level and MetS was found preferentially in postmenopausal women (OR = 2.30, 95%CI: 1.31, 4.05). In addition, GAL-3BP was increased in the serum and visceral adipose tissue (VAT) of high fat diet (HFD) mice. Moreover, GAL-3BP was highly expressed in VAT macrophages.ConclusionsThis study confirmed serum GAL-3BP to be positively associated with MetS, highlighting it as a useful biological marker of MetS in Chinese participants.

scholarly journals Solid Cell Nests Within a Parathyroid Gland—Report of an Exceptional Case

2018 ◽  
Vol 29 (4) ◽  
pp. 365-368
Author(s):  
C. Christofer Juhlin ◽  
Inga-Lena Nilsson ◽  
Anders Höög
Keyword(s):  
Parathyroid Gland ◽  
Exceptional Case ◽  
Solid Cell Nests ◽  
Solid Cell
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