scholarly journals Androgen Receptor Expression in the Caput Epididymal Epithelium Is Essential for Development of the Initial Segment and Epididymal Spermatozoa Transit

2011 ◽  
Vol 32 (1) ◽  
pp. 152-152
Author(s):  
Laura O'Hara ◽  
Michelle Welsh ◽  
Philippa T. K. Saunders ◽  
Lee B. Smith
Keyword(s):  
Androgen Receptor ◽  
Initial Segment ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Epididymal Spermatozoa

Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog

2006 ◽  
Vol 81 (2) ◽  
pp. 231-236 ◽  
Author(s):  
G. Pisani ◽  
F. Millanta ◽  
D. Lorenzi ◽  
I. Vannozzi ◽  
A. Poli
Keyword(s):  
Androgen Receptor ◽  
Receptor Expression ◽  
Androgen Receptor Expression

scholarly journals Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse

Endocrinology ◽  
2005 ◽  
Vol 146 (10) ◽  
pp. 4340-4348 ◽  
Author(s):  
Johanna S. Schneider ◽  
Carly Burgess ◽  
Nicole C. Sleiter ◽  
Lydia L. DonCarlos ◽  
John P. Lydon ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Androgen Receptor ◽  
Progesterone Receptor ◽  
Sexual Behaviors ◽  
Gene Deletion ◽  
Biological Significance ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Testicular Development ◽  
Testicular Weight

Reproductive and behavioral functions of progesterone receptors (PRs) in males were assessed by examining consequences of PR gene deletion. Basal hormone levels were measured in male progesterone receptor knockout (PRKO) mice and compared to wild-type (WT) counterparts. RIA of serum LH, testosterone, and progesterone levels revealed no significant differences. Levels of FSH were moderately but significantly lower and inhibin levels were higher in PRKOs; these differences were not accompanied by gross differences in testicular weight or morphology. PRKOs exhibited significant alterations in sexual behavior. In initial tests PRKOs exhibited reduced latency to mount, compared with WT. In second sessions, PRKOs again showed a significantly reduced latency to mount and increased likelihood of achieving ejaculation. RU486 treatment in WT produced increased mount and intromission frequency and decreased latency to intromission. In anxiety-related behavior tests, PRKO mice exhibited intermediate anxiety levels, compared with WT, suggesting that enhanced sexual behavior in PRKOs is not secondary to reduced anxiety. Immunohistochemical analysis revealed significantly enhanced androgen receptor expression in the medial preoptic nucleus and bed nucleus of the stria terminalis of PRKO. We conclude that testicular development and function and homeostatic regulation of the hypothalamic-pituitary testicular axis are altered to a lesser extent by PR gene deletion. In contrast, PR appears to play a substantial role in inhibiting the anticipatory/motivational components of male sexual behavior in the mouse. The biological significance of this inhibitory mechanism and the extent to which it is mediated by reduced androgen receptor expression remain to be clarified.

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