A Water-Soluble Human Chorionic Gonadotropin-Binding Component Obtained from Leydig Cell Membrane Fractions*

Endocrinology ◽  
1978 ◽  
Vol 102 (3) ◽  
pp. 814-823 ◽  
Author(s):  
VOLKER G. PAHNKE ◽  
FREIMUT A. LEIDENBERGER
Keyword(s):  
Cell Membrane ◽  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Human Chorionic Gonadotropin ◽  
Water Soluble ◽  
Binding Component

Ultrastructural Features of Leydig Cell Hyperplasia Due to an hCG-Producing Testicular Tumor

1982 ◽  
Vol 40 ◽  
pp. 212-213
Author(s):  
S. L. Asa ◽  
T. A. Bayley ◽  
E. Horvath ◽  
K. Kovacs
Keyword(s):  
Laboratory Investigation ◽  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Human Chorionic Gonadotropin ◽  
Testicular Tumor ◽  
Testicular Neoplasms ◽  
Medical Attention ◽  
Human Testis ◽  
Cell Hyperplasia ◽  
Chronic Stimulation

Leydig cell clusters in the adult human testis are known to enlarge during chronic stimulation with excess LH as in Klinefelter's syndrome or following administration of exogenous human chorionic gonadotropin (hCG). However, the ultrastructural features of this hyperplasia, to our knowledge, have not been reported in association with testicular neoplasms producing hCG.We report the case of a 21-year-old man who sought medical attention because of gynecomastia. Laboratory investigation revealed a marked increase in serum hCG and elevated a-fetoprotein. A testicular mass was palpable on examination and the patient underwent orchiectomy.

Leydig Cell Responsiveness to Single and Repeated Human Chorionic Gonadotropin Administration

1979 ◽  
Vol 49 (1) ◽  
pp. 12-14 ◽  
Author(s):  
ANTHONY G. H. SMALS ◽  
GERLAG F. F. M. PIETERS ◽  
JULES HIRSCH ◽  
JAN I. M. DRAYER ◽  
THEO J. BENRAAD ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Human Chorionic Gonadotropin

Hyperreactio luteinalis in association with multiple foetal malformations – a consequence of supra-physiological HCG?

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Majed Faden ◽  
Amir H. Salehi ◽  
Jeannine Simon ◽  
Moy Fong Chen ◽  
Atilla Omeroglu ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Human Chorionic Gonadotropin ◽  
Ultrasound Examination ◽  
Second Trimester ◽  
Cell Hyperplasia ◽  
Foetal Development ◽  
Rare Finding ◽  
Testicular Hypertrophy ◽  
Foetal Malformations

AbstractHyperreactio luteinalis (HL) is characterised by ovarian cystic enlargement that is associated with high levels of human chorionic gonadotropin (hCG). Here the possible effects of abnormally high hCG levels on foetal development are demonstrated.We report a 28-year-old patient who was referred for evaluation of bilateral maternal ovarian enlargement in the second trimester. Abnormally elevated hCG (887,514 IU/L) was found with ultrasound examination identifying various foetal malformations. The karyotype was normal. Spontaneous abortion occurred at 20 weeks. Autopsy showed testicular hypertrophy with marked Leydig cell hyperplasia. The HL resolved with normalisation of the hCG levels following delivery.HL is a rare finding in normal pregnancies; the potential effects of abnormally elevated hCG on the foetus are discussed.

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