Diltiazem stimulates parathyroid hormone secretion in vivo whereas felodipine does not

1993 ◽  
Vol 76 (4) ◽  
pp. 890-894 ◽  
Author(s):  
L. Villiger
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion

Comparison of the feedback effect of magnesium and calcium on parathyroid hormone secretion in man

1987 ◽  
Vol 113 (1) ◽  
pp. 117-122 ◽  
Author(s):  
O. Ferment ◽  
P. E. Garnier ◽  
Y. Touitou
Keyword(s):  
Parathyroid Hormone ◽  
Urinary Excretion ◽  
Hormone Secretion ◽  
Plasma Concentrations ◽  
Magnesium Salt ◽  
Saline Injection ◽  
Molar Basis ◽  
Magnesium Salts ◽  
High Doses

ABSTRACT Administration of high doses of magnesium is known to produce a decrease in parathyroid hormone (PTH) secretion in human patients but the effect of magnesium on the secretion of PTH in healthy man is not known. We have looked at the effect of a relatively moderate i.v. dose of magnesium (7·08 mmol) in seven healthy men. In addition and for comparison the effect of calcium (4·25 mmol) was studied. Two magnesium salts were considered, magnesium sulphate (MgSO4) and magnesium pyrrolidone carboxylate (MgPC). Four i.v. injections were given at 08.00 h (MgPC, NaCl (control), MgSO4 and Ca gluconate), with an interval of 1 week between each injection. Whatever the magnesium salt the variations in plasma concentrations of magnesium were the same whereas no change in erythrocyte magnesium was observed. Plasma concentration of C-terminal PTH did not show significant variations after MgPC or saline injection. Both MgSO4 and Ca gluconate produced a statistically significant 30% decrease in plasma PTH levels 45 min after the injection. The effect was more sustained with calcium (2 h) than with magnesium (45 min). The urinary excretion of magnesium was significantly higher after injection of MgSO4 than after MgPC. These results suggest (1) that magnesium was, on a molar basis, less potent than calcium in regulating PTH secretion in vivo, (2) that the nature of the magnesium salt used must be kept in mind for the interpretation of the effect of magnesium on PTH secretion in vivo and (3) that the decrease in plasma PTH can partly explain the larger urinary excretion of magnesium after MgSO4 than after MgPC. J. Endocr. (1987) 113, 117–122

Prolactin stimulation of parathyroid hormone secretion in bovine parathyroid cells

1984 ◽  
Vol 247 (5) ◽  
pp. E675-E680 ◽  
Author(s):  
L. Magliola ◽  
L. R. Forte
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion ◽  
Vitamin D Metabolism ◽  
Parathyroid Function ◽  
Wide Range ◽  
Camp Levels ◽  
Bovine Species ◽  
Ca Homeostasis

Previous studies have suggested that prolactin (PRL) may affect calcium (Ca) homeostasis by an action on vitamin D metabolism. In this study, the effects of PRL on parathyroid hormone (PTH) secretion were investigated in dispersed bovine parathyroid cells (PTC). PRL (0.013-1.3 microM) caused concentration-dependent increases in PTH secretion. PRL-stimulated PTH release was apparent as early as 1 h and was progressive thereafter for up to 3 h. PRL enhanced PTH release over a wide range of ambient Ca concentrations (0.5-2.0 microM). Ovine and rat PRL were more effective than bovine PRL in stimulating PTH secretion. This effect was apparently specific for PRL because neither ovine nor bovine growth hormone stimulated PTH secretion. PRL-stimulated PTH release was not mediated through the beta-adrenergic or dopaminergic receptor systems of PTC and was not associated with increased adenosine 3',5'-cyclic monophosphate (cAMP) levels. This study demonstrated a direct effect of PRL to stimulate PTH secretion in vitro. Although these data do not provide evidence for an effect of PRL in vivo, we suggest a mechanism by which PRL may influence parathyroid function and Ca homeostasis in the bovine species.

scholarly journals Fluoride Modulates Parathyroid Hormone Secretion in vivo and in vitro

2015 ◽  
Vol 200 (6) ◽  
pp. 413-423 ◽  
Author(s):  
Chaitanya P. Puranik ◽  
Kathleen A. Ryan ◽  
Zhaoyu Yin ◽  
E. Angeles Martinez-Mier ◽  
John S. Preisser ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion

scholarly journals A Novel Calcium-Sensing Receptor Antagonist Transiently Stimulates Parathyroid Hormone Secretion in Vivo

Endocrinology ◽  
2005 ◽  
Vol 146 (4) ◽  
pp. 2015-2022 ◽  
Author(s):  
Brian J. Arey ◽  
Ramakrishna Seethala ◽  
Zhengping Ma ◽  
Aberra Fura ◽  
Jennifer Morin ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Receptor Antagonist ◽  
Hormone Secretion ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

Regulation of parathyroid hormone secretion in vitro and in vivo

1982 ◽  
Vol 34 (1) ◽  
pp. 313-316 ◽  
Author(s):  
J. A. Fischer ◽  
J. W. Blum ◽  
W. Born ◽  
M. A. Dambacher ◽  
D. W. Dempster
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion

scholarly journals Parathyroid Hormone: Secretion and Metabolism In Vivo

1971 ◽  
Vol 68 (12) ◽  
pp. 2986-2991 ◽  
Author(s):  
J. F. Habener ◽  
D. Powell ◽  
T. M. Murray ◽  
G. P. Mayer ◽  
J. T. Potts
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion

scholarly journals Effect of Phosphate on Parathyroid Hormone Secretion In Vivo

1999 ◽  
Vol 14 (11) ◽  
pp. 1848-1854 ◽  
Author(s):  
Jose C. Estepa ◽  
Escolastico Aguilera-Tejero ◽  
Ignacio Lopez ◽  
Yolanda Almaden ◽  
Mariano Rodriguez ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion
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