Pseudohypoparathyroidism and Idiopathic Hypoparathyroidism: Relationship between Serum Calcium and Parathyroid Hormone Levels and Urinary Cyclic Adenosine-3′,5′- Monophosphate Response to Parathyroid Extract*

1978 ◽  
Vol 46 (6) ◽  
pp. 872-879 ◽  
Author(s):  
EDMOND A. WERDER ◽  
JAN A. FISCHER ◽  
RUTH ILLIG ◽  
HANS P. KIND ◽  
SERGIO BERNASCONI ◽  
...  
2019 ◽  
Author(s):  
Saba Hafeez ◽  
Muhammad Saad ◽  
Hajira Ilyas ◽  
Aisling Smith ◽  
Anand Velusamy ◽  
...  

2019 ◽  
Vol 3 (12) ◽  
pp. 2224-2235 ◽  
Author(s):  
Aditya Dutta ◽  
Rimesh Pal ◽  
Nimisha Jain ◽  
Pinaki Dutta ◽  
Ashutosh Rai ◽  
...  

Abstract Primary hyperparathyroidism (PHPT) is a rare endocrine disease in the pediatric population. Sporadic parathyroid adenomas remain the most common cause of pediatric PHPT. Parathyroid carcinoma (PC) is an extremely rare cause of pediatric PHPT. We report a 16-year-old boy presenting with a nonhealing fragility fracture of the right leg along with florid features of rickets. Examination revealed a neck mass, mimicking a goiter. Biochemical findings were consistent with PHPT. Imaging was suggestive of a right inferior parathyroid mass infiltrating the right lobe of thyroid. The patient underwent en bloc surgical excision of the parathyroid mass along with the right lobe of thyroid. Histopathology was suggestive of a PC. He achieved biochemical remission with normalization of serum calcium and parathyroid hormone levels. At follow-up, there was no biochemical or imaging evidence of recurrence or metastasis. Genetic analysis revealed heterozygous germline deletion of CDC73. An extensive literature search on PC was conducted, with an emphasis on the pediatric population. Thirteen cases of pediatric PC were identified. The median age of presentation was 13 years; there was no sex predilection. All cases were symptomatic; 31% had a visible neck mass. The median serum calcium and intact parathyroid hormone levels were 14.3 mg/dL and 2000 pg/mL, respectively. All patients underwent surgical excision, with 27% showing metastatic relapse. Our findings indicate that the preoperative features that could point toward a diagnosis of PC in a child with PHPT are a tumor size of >3 cm, thyroid infiltration on imaging, and severe hypercalcemia at presentation.


1976 ◽  
Vol 5 ◽  
pp. 289-304 ◽  
Author(s):  
Betty S. Roof ◽  
Carolyn F. Piel ◽  
James Hansen ◽  
H.Hugh Fudenberg

2002 ◽  
Vol 10 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Wan-Ping Lee ◽  
Li-Wei Lin ◽  
Shu-Hui Yeh ◽  
Rosa Huang Liu ◽  
Cheun-Fen Tseng

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110590
Author(s):  
Shigeru Nagaki ◽  
Emiko Tachikawa ◽  
Hitomi Kodama ◽  
Takao Obara ◽  
Makiko Osawa ◽  
...  

We report a 21-year-old woman with Turner’s syndrome, Graves’ disease and primary hyperparathyroidism. At 12 years of age, she was of short stature, and was diagnosed with Turner’s syndrome and treated with growth hormone. At the age of 17 years, she was diagnosed with Graves’ disease. On treatment with methimazole, her laboratory findings normalized. At the age of 20 years, her serum calcium and intact parathyroid hormone levels were high. The upper left parathyroid gland showed swelling and was resected, and adenoma was diagnosed pathologically. Then, primary hyperparathyroidism induced by the adenoma was diagnosed. After the parathyroidectomy, the patient’s serum calcium and intact parathyroid hormone levels normalized. Is likely that Turner’s syndrome and Graves’ disease were not associated with primary hyperparathyroidism. Multiple endocrine neoplasia type 1 was unlikely considering the clinical, laboratory, ultrasonographic, and scintigraphic findings.


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