Evidence for Leydig Cell Dysfunction in Infertile Men with a Selective Increase in Plasma Follicle-Stimulating Hormone*

1987 ◽  
Vol 64 (6) ◽  
pp. 1194-1198 ◽  
Author(s):  
JOHN D. BOOTH ◽  
GEORGE R. MERRIAM ◽  
RICHARD V. CLARK ◽  
D. LYNN LORIAUX ◽  
RICHARD J. SHERINS
Keyword(s):  
Leydig Cell ◽  
Follicle Stimulating Hormone ◽  
Cell Dysfunction ◽  
Infertile Men ◽  
Selective Increase ◽  
Stimulating Hormone

Endocrine and local testicular regulation

2011 ◽  
pp. 1347-1353
Author(s):  
Ilpo Huhtaniemi
Keyword(s):  
Growth Factors ◽  
Luteinizing Hormone ◽  
Leydig Cell ◽  
Follicle Stimulating Hormone ◽  
Regulatory System ◽  
The Other ◽  
Seminiferous Tubules ◽  
Testicular Function ◽  
Cell Product ◽  
Stimulating Hormone

The testis has two functions, androgen production and spermatogenesis, and a key role in their regulation is played by the two pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone (FSH). Other hormones and growth factors also influence testicular function, often by modulating the gonadotropin effects. Moreover, a plethora of local paracrine and autocrine signals within the testis are known. The main testicular hormone, testosterone, a Leydig cell product, regulates spermatogenesis in seminiferous tubules in paracrine fashion. The other functions of testosterone are endocrine, occurring outside the testis. This chapter summarizes the main hormonal regulatory system of the testis, the hypothalamic–pituitary–testicular axis, and how its effects are modulated by other extratesticular hormones and local testicular factors.

EFFECT OF TESTOSTERONE PROPIONATE ON THE RELEASE OF FSH FROM THE PITUITARY GLAND

1968 ◽  
Vol 57 (2) ◽  
pp. 289-295 ◽  
Author(s):  
E. Steinberger ◽  
G. Duckett
Keyword(s):  
Pituitary Gland ◽  
Leydig Cell ◽  
Testosterone Propionate ◽  
Follicle Stimulating Hormone ◽  
Inhibitory Effect ◽  
Blood Levels ◽  
Rat Pituitary ◽  
Pituitary Glands ◽  
Marked Drop ◽  
Stimulating Hormone

ABSTRACT On the basis of a study of changes in follicle stimulating hormone (FSH) levels in rat pituitary glands, obtained at various times after orchiectomy, it has been previously suggested that the Leydig cell secretions may regulate the release of FSH from the pituitary gland (Steinberger & Duckett 1966). This hypothesis was put to test in the present study. FSH levels have been determined in the pituitary gland and plasma of normal, testosterone-treated, orchiectomized, and orchiectomized testosteronetreated rats. A marked drop of pituitary FSH levels, associated with an elevation of plasma FSH levels, was observed in orchiectomized rats. Administration of testosterone to orchiectomized rats prevented the drop in pituitary FSH levels and rendered the blood levels undetectable. These results are interpreted as supporting the hypothesis that testosterone has an inhibitory effect on the release of FSH from the pituitary gland.

scholarly journals Isolated follicle-stimulating hormone (FSH) deficiency in two infertile men without FSH β gene mutation: Case report and literature review

2019 ◽  
Vol 80 (4) ◽  
pp. 234-239
Author(s):  
Charlotte Rougier ◽  
Sylvie Hieronimus ◽  
Patricia Panaïa-Ferrari ◽  
Najiba Lahlou ◽  
Françoise Paris ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Gene Mutation ◽  
Follicle Stimulating Hormone ◽  
Infertile Men ◽  
Stimulating Hormone
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