scholarly journals High-Dose Growth Hormone (GH) Treatment in Non-GH-Deficient Children Born Small for Gestational Age Induces Growth Responses Related to Pretreatment GH Secretion and Associated with a Reversible Decrease in Insulin Sensitivity

2002 ◽  
Vol 87 (1) ◽  
pp. 148-148 ◽  
Author(s):  
Francis de Zegher ◽  
Ken Ong ◽  
Maria van Helvoirt ◽  
Angelica Mohn ◽  
Katie Woods ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
High Dose ◽  
Growth Responses ◽  
Gh Treatment ◽  
Gh Secretion

scholarly journals Delayed Bone Age Might Accelerate the Response to Human Growth Hormone Treatment in Small for Gestational Age Children with Short Stature

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Jung-Eun Moon ◽  
Cheol Woo Ko
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Human Growth ◽  
Bone Age ◽  
Pediatric Endocrinology ◽  
Gh Therapy ◽  
Gh Treatment ◽  
The Impact

Purpose. Growth hormone (GH) treatment is recommended to improve growth and psychosocial problems in short stature children born small for gestational age (SGA). Although GH therapy in these patients has been extensively studied, the impact of therapy according to delays in bone age (BA) is not known well. Objective. To investigate the effects of GH therapy in SGA patients with short stature according to BA delay. Methods. We retrospectively analyzed changes in height SD score (SDS) and BA/chronological age (CA) after 6 and 12 months of GH therapy in patients grouped according to BA delay. We studied 27 SGA children with short stature in the pediatric endocrinology clinic of Kyungpook National University Children’s Hospital. Results. Of the 27 patients, 9 had <2 years of BA delay, while 18 had >2 years of delay. There were no significant differences between the two groups in terms of gestational age and weight at birth, height SDS, IGF-1 SDS, and growth hormone dosage at the beginning of therapy. However, height SDS increased significantly in the group with >2 years of BA delay after 6 months of GH therapy (−2.50 ± 0.61 vs −1.87 ± 0.82; p=0.037) and 12 months (−2.27 ± 0.70 vs −1.63 ± 0.65; p=0.002). When height SDS was compared between with and without GHD, there were no significant differences. Conclusions. Delayed BA (>2 years) may impact the response to GH treatment in SGA children with short stature.

Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational age

2003 ◽  
Vol 142 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Wayne S. Cutfield ◽  
Wendy E. Jackson ◽  
Craig Jefferies ◽  
Elizabeth M. Robinson ◽  
Bernhard H. Breier ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Hormone Therapy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Growth Hormone Therapy ◽  
Short Children

Insulin Sensitivity Decreases in Short Children Born Small for Gestational Age Treated with Growth Hormone

2009 ◽  
Vol 154 (4) ◽  
pp. 509-513 ◽  
Author(s):  
Sara Bachmann ◽  
Susanne Bechtold ◽  
Walter Bonfig ◽  
Stephanie Putzker ◽  
Matthias Buckl ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Short Children

High-dose growth hormone therapy for short children born small for gestational age

1994 ◽  
Vol 83 (s399) ◽  
pp. 77-77 ◽  
Author(s):  
F Zegher ◽  
M Maes ◽  
C Heinrichs ◽  
G Thiry ◽  
MVL Caju ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Therapy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Growth Hormone Therapy ◽  
High Dose ◽  
Short Children

Growth Hormone Treatment in Children Born Small for Gestational Age—Adult Height and Metabolic Consequences

2010 ◽  
Vol 06 (01) ◽  
pp. 63
Author(s):  
Michelle L Klein ◽  
Robert Rapaport ◽  
◽  
Keyword(s):  
Growth Hormone ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Growth Velocity ◽  
Adult Height ◽  
Prediction Models ◽  
Short Term ◽  
Gh Treatment ◽  
Long Term Studies

Short-term studies of children born small for gestational age (SGA) who do not adequately catch up have shown that growth hormone (GH) treatment over a range of doses is both safe and effective at increasing growth velocity and height standard deviation (SD). Long-term studies have shown an improvement in adult height compared with untreated controls. Predictors of growth response include height and weight at start of GH treatment, pre-treatment growth velocity, target height, and pre-pubertal years treated with GH. Height prediction models are being developed to help maximize GH treatment response. While some short-term studies of GH treatment in SGA children have shown abnormalities in carbohydrate metabolism, long-term studies have demonstrated that these changes were transient. GH treatment has been shown to be safe and effective in increasing adult height of children born SGA. Follow-up is needed for assessment of the long-term effects of GH treatment.

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