Defective brain and muscle energy metabolism shown by in vivo 31P magnetic resonance spectroscopy in nonaffected carriers of 11778 mtDNA mutation

Neurology ◽  
1995 ◽  
Vol 45 (7) ◽  
pp. 1364-1369 ◽  
Author(s):  
B. Barbiroli ◽  
P. Montagna ◽  
P. Cortelli ◽  
S. Iotti ◽  
R. Lodi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Mtdna Mutation ◽  
31P Magnetic Resonance Spectroscopy ◽  
Muscle Energy ◽  
Muscle Energy Metabolism

Magnetic Resonance Spectroscopy Studies in Migraine

Cephalalgia ◽  
1994 ◽  
Vol 14 (3) ◽  
pp. 184-193 ◽  
Author(s):  
P Montagna ◽  
P Cortelli ◽  
B Barbiroli
Keyword(s):  
Energy Metabolism ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Mitochondrial Oxidative Phosphorylation ◽  
Muscle Energy ◽  
Spectroscopy Studies ◽  
Muscle Energy Metabolism ◽  
Impaired Energy Metabolism ◽  
Brain Energy

We describe the method of 31phosphorous magnetic resonance spectroscopy and review the results when it is applied to the study of brain and muscle energy metabolism in migraine subjects. Brain energy metabolism appears to be abnormal in all major subtypes of migraine when measured both during and between attacks. Impaired energy metabolism is also documented in skeletal muscle. We suggest that migraine is associated with a generalized disorder of mitochondrial oxidative phosphorylation and that this may constitute a threshold for the triggering of migraine attacks.

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