Acute therapy for cluster headache with sumatriptan: Findings of a one-year long-term study

Neurology ◽  
1998 ◽  
Vol 51 (3) ◽  
pp. 908-911 ◽  
Author(s):  
H. Gobel ◽  
V. Lindner ◽  
A. Heinze ◽  
M. Ribbat ◽  
G. Deuschl
Keyword(s):  
Cluster Headache ◽  
Term Study ◽  
Acute Therapy ◽  
Long Term Study ◽  
One Year

scholarly journals Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study

1990 ◽  
Vol 23 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Ana Lúcia C. Domingues ◽  
Amaury D. Coutinho
Keyword(s):  
Gamma Globulin ◽  
Serum Levels ◽  
Cure Rate ◽  
Term Study ◽  
Long Term Study ◽  
Schistosomiasis Mansoni ◽  
Progression Of Disease ◽  
One Year ◽  
Hepatosplenic Schistosomiasis

Forty-two with hepatosplenic patients treated with praziquantel and followed up for 5 years. One half of the patients received a single 30 mg/kg dose and the other half, two doses of 25 mg/kg given 4 hrs apart. According to Hoffman and Kato-Katz stool exams, an 83.3% cure rate, was observed after twelve months. Stool egg counts in cases of incomplete cure were greatly reduced. Liver function, as assessed by serum levels of aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase activities as well as albumin and gamma globulin showed marked improvement after one year. Hepatomegaly was reduced in 81.0% of patients and splenomegaly in 78.8%. Spleen regression was complete in 15.1% of the total, and in 18.5% of those with compensated hepatosplenic disease. As a result of these observations, the authors recomend early treatment with anti-schistosomal medication, either oxamniquine or praziquantel, to halt progression of disease and reduce splenomegaly.

scholarly journals The Persistence of Glyphosate in Vegetation One Year after Application

Forests ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 601
Author(s):  
Christopher B. Edge ◽  
Marika I. Brown ◽  
Shane Heartz ◽  
Dean Thompson ◽  
Len Ritter ◽  
...  
Keyword(s):  
Daily Intake ◽  
Black Bear ◽  
Maximum Level ◽  
Term Study ◽  
Traditional Medicines ◽  
Long Term Study ◽  
Maximum Residue Level ◽  
Operational Practices ◽  
One Year

Glyphosate-based herbicides are the most widely used herbicides in the world, including in Canadian forestry. In general, glyphosate-based herbicides are considered relatively non-toxic to wildlife species due, in part, to rapid breakdown of the chemical in the environment. However, recent work has shown that glyphosate can persist for at least one year after application at low concentrations leading to concern over the persistence of trace levels in the environment. Using two independent studies we characterize the short- (18 days) and long-term (1 year) persistence of glyphosate in vegetation which are commonly, but differentially, browsed by WhiteiTailed Deer (Odocoileus virginianus), Moose (Alces alces), and Black Bear (Ursus americanus), or used as traditional medicines by Indigenous people and compare the residues to exposure thresholds. In the short-term study, glyphosate concentrations within the application block exceeded the general and maximum residue level (MRL) for fresh fruit set by Health Canada (0.1 ppm) for up to 18 days after application. In the long-term study, glyphosate concentrations were above the MRL one week after application and below the MRL one month and one year after application. Under the assumptions that all vegetation contained glyphosate at the highest observed concentration, animals only consume vegetation from herbicide treated areas, and animals consume the physiological maximum level of vegetation daily, Moose, White-Tailed Deer, and Black Bears could exceed the Acceptable Daily Intake for glyphosate (0.3 mg/kg/day) for up to 18 days after application. Subsequently, given dissipation of residues in vegetative matrices as observed in this study, we consider it highly unlikely that the species considered herein could consume enough vegetation throughout their lives to pose a risk to their health. Overall, our two independent studies demonstrate that trace levels of glyphosate persist in vegetation for up to one year after application, however, observed concentrations are unlikely to pose risk to wildlife. We caution that operational practices as typically imposed in Canadian forestry are very important and effective in minimizing risk.

scholarly journals Kontrowersje wokół długoterminowych badań Gillesa-Erica Séraliniego nad bezpieczeństwem zdrowotnym kukurydzy GMO

2014 ◽  
Vol 12 (3) ◽  
pp. 33-54
Author(s):  
Katarzyna Lisowska ◽  
Alexander Cortez
Keyword(s):  
Safety Evaluation ◽  
Negative Effects ◽  
Short Term ◽  
Term Study ◽  
Experimental Animals ◽  
Long Term Study ◽  
Chemical Toxicology ◽  
The Subject ◽  
One Year

At the end of the year 2012, Food and Chemical Toxicology published a long-term study by Seralini et al., describing the safety evaluation of genetically modified NK603 maize and Roundup herbicide. Contrary to previous, short-term studies, this experiment revealed some negative effects of these substances on the health of experimental animals. GM feeds and Roundup generate revenue worth millions of dollars. This may be the reason why Seralini’s paper has became the subject of much heated criticism, mainly from parties linked to business and agro-biotechnology. After one year of debate, the editors of Food Chem Toxicol. decided to retract the paper, an unprecedented event given that the published article was peer-reviewed and there was no evidence of plagiarism or fraud. Here, we stress the results of Seralini’s study, discuss the methodological hints of that work and cite the commentaries on the whole situation.

Weather Interference on Cluster Headache Temporal Pattern. A Cooperative International Long-Term Study

Cephalalgia ◽  
1989 ◽  
Vol 9 (10_suppl) ◽  
pp. 195-196
Author(s):  
Giuseppe Nappi ◽  
Ottar Sjaastad ◽  
Edgard Raffaelli ◽  
Jorge A. Leston ◽  
G. Micieli ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Temporal Pattern ◽  
Term Study ◽  
Long Term Study

Repeated Botox Injections Deemed Safe in Long-Term Study

2005 ◽  
Vol 36 (1) ◽  
pp. 2
Author(s):  
BETSY BATES
Keyword(s):  
Term Study ◽  
Long Term Study

Long-Term Study Proves Permanent Filler Safety

2010 ◽  
Vol 41 (4) ◽  
pp. 23
Author(s):  
BRUCE JANCIN
Keyword(s):  
Term Study ◽  
Long Term Study ◽  
Permanent Filler
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