Phase I Human Safety Assessment of Intrathecal Neostigmine Containing Methyl- and Propylparabens

Anesthesia & Analgesia ◽

10.1213/00000539-199710000-00024 ◽

1997 ◽

Vol 85 (4) ◽

pp. 842-846 ◽

Author(s):

James C. Eisenach ◽

David D. Hood ◽

Regina Curry

Keyword(s):

Phase I ◽

Safety Assessment ◽

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Phase I Human Safety Assessment of Intrathecal Neostigmine Containing Methyl- and Propylparabens

Anesthesia & Analgesia ◽

10.1097/00000539-199710000-00024 ◽

1997 ◽

Vol 85 (4) ◽

pp. 842-846 ◽

Author(s):

James C. Eisenach ◽

David D. Hood ◽

Regina Curry

Keyword(s):

Phase I ◽

Safety Assessment ◽

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Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose metrics considerations

Toxicology in Vitro ◽

10.1016/j.tiv.2021.105171 ◽

2021 ◽

pp. 105171

Author(s):

Hequn Li ◽

Haitao Yuan ◽

Alistair Middleton ◽

Jin Li ◽

Beate Nicol ◽

...

Keyword(s):

Risk Assessment ◽

Safety Assessment ◽

Next Generation ◽

Human Safety ◽

Physiologically Based ◽

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First-in-human safety, tolerability, and pharmacokinetics of ammoxetine in healthy subjects: a randomized, double-blind, placebo-controlled phase I study

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2021.105724 ◽

2021 ◽

Vol 159 ◽

pp. 105724

Author(s):

Qi Shen ◽

Chao Hu ◽

Jia Miao ◽

Junxia Chen ◽

Yueying Peng ◽

...

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Phase I Study ◽

Double Blind ◽

Double Blind Placebo ◽

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Pharmacokinetic bioequivalence and safety assessment of two metformin hydrochloride tablet formulations using a phase I, randomized, open, two-period, two cross-over, single-dose, fed study in healthy Chinese adult subjects

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp204002 ◽

2021 ◽

Author(s):

Ming-Li Sun ◽

Lu Qi ◽

Xiang-Dong Luo ◽

Yuan-Xu Tong ◽

Yu Wang ◽

...

Keyword(s):

Single Dose ◽

Phase I ◽

Safety Assessment ◽

Metformin Hydrochloride ◽

Chinese Adult ◽

Tablet Formulations ◽

Healthy Chinese

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Phase I Study of the Bifunctional Fusion Protein Bintrafusp Alfa in Asian Patients with Advanced Solid Tumors, Including a Hepatocellular Carcinoma Safety‐Assessment Cohort

The Oncologist ◽

10.1634/theoncologist.2020-0249 ◽

2020 ◽

Vol 25 (9) ◽

Author(s):

Toshihiko Doi ◽

Yutaka Fujiwara ◽

Takafumi Koyama ◽

Masafumi Ikeda ◽

Christoph Helwig ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Fusion Protein ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Safety Assessment ◽

Advanced Solid Tumors ◽

Asian Patients ◽

Bifunctional Fusion Protein

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P.6.c.003 Aripirazole for methamphetamine dependence; a phase I human safety study

European Neuropsychopharmacology ◽

10.1016/s0924-977x(07)70854-4 ◽

2007 ◽

Vol 17 ◽

pp. S550-S551

Author(s):

A. Elkashef ◽

T. Newton ◽

R. De la Garza ◽

M. Reid ◽

J. Mojsiak

Keyword(s):

Phase I ◽

Safety Study ◽

Human Safety ◽

Methamphetamine Dependence

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Phase I Safety Assessment of Intrathecal Oxytocin

Survey of Anesthesiology ◽

10.1097/sa.0000000000000198 ◽

2016 ◽

Vol 60 (1) ◽

pp. 33

Author(s):

James C. Eisenach ◽

Chuanyao Tong ◽

Regina Curry

Keyword(s):

Phase I ◽

Safety Assessment

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Agricultural Chemical Safety Assessment: A Multisector Approach to the Modernization of Human Safety Requirements

Critical Reviews in Toxicology ◽

10.1080/10408440500534354 ◽

2006 ◽

Vol 36 (1) ◽

pp. 1-7 ◽

Author(s):

Neil G. Carmichael ◽

Hugh A. Barton ◽

Alan R. Boobis ◽

Ralph L. Cooper ◽

Vicki L. Dellarco ◽

...

Keyword(s):

Safety Assessment ◽

Chemical Safety ◽

Safety Requirements ◽

Human Safety ◽

Agricultural Chemical

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A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies

10.1186/1471-2407-13-152 ◽

2013 ◽

Vol 13 (1) ◽

Author(s):

Jonathan W Goldman ◽

Robert N Raju ◽

Gregory A Gordon ◽

Iman El-Hariry ◽

Florentina Teofilivici ◽

...

Keyword(s):

Phase I ◽

Phase I Study ◽

Hsp90 Inhibitor ◽

Clinical Activity ◽

Weekly Administration ◽

Human Safety ◽

Activity Phase ◽

Solid Malignancies

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Revisiting the value of mouse carcinogenicity bioassays for human safety assessment

Toxicology Letters ◽

10.1016/j.toxlet.2012.03.636 ◽

2012 ◽

Vol 211 ◽

pp. S176 ◽

Author(s):

Richard Billington ◽

Tina Mehta ◽

Richard Lewis ◽

Bennard van Raavenzway ◽

Christian Strupp ◽

...

Keyword(s):

Safety Assessment ◽

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