CoREST acts as a positive regulator of Notch signaling in the follicle cells ofDrosophila melanogaster

Development ◽  
2012 ◽  
Vol 139 (6) ◽  
pp. e608-e608
Author(s):  
E. Domanitskaya ◽  
T. Schupbach
Keyword(s):  
Notch Signaling ◽  
Follicle Cells ◽  
Positive Regulator

scholarly journals CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila

2011 ◽  
Vol 356 (1) ◽  
pp. 128-129
Author(s):  
Elena Domanitskaya ◽  
Trudi Schupbach
Keyword(s):  
Notch Signaling ◽  
Follicle Cells ◽  
Positive Regulator

scholarly journals Drosophila Rabconnectin3 alpha and beta regulate trafficking and Notch signaling in the follicle cells

2008 ◽  
Vol 319 (2) ◽  
pp. 527-528
Author(s):  
Yan Yan ◽  
Natalie Denef ◽  
Trudi Schupbach
Keyword(s):  
Notch Signaling ◽  
Follicle Cells

scholarly journals The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells

Development ◽  
2011 ◽  
Vol 138 (9) ◽  
pp. 1737-1745 ◽  
Author(s):  
J. S. Poulton ◽  
Y.-C. Huang ◽  
L. Smith ◽  
J. Sun ◽  
N. Leake ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Temporal Pattern ◽  
Follicle Cells ◽  
Microrna Pathway

The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells

2011 ◽  
Vol 124 (9) ◽  
pp. e1-e1
Author(s):  
J. S. Poulton ◽  
Y.-C. Huang ◽  
L. Smith ◽  
J. Sun ◽  
N. Leake ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Temporal Pattern ◽  
Follicle Cells ◽  
Microrna Pathway

scholarly journals Notch Signaling and Developmental Cell-Cycle Arrest in Drosophila Polar Follicle Cells

2009 ◽  
Vol 20 (24) ◽  
pp. 5064-5073 ◽  
Author(s):  
Li-Fang Shyu ◽  
Jianjun Sun ◽  
Hui-Min Chung ◽  
Yi-Chun Huang ◽  
Wu-Min Deng
Keyword(s):  
Cell Cycle ◽  
Notch Signaling ◽  
Cell Cycle Arrest ◽  
Developmental Regulation ◽  
Cell Types ◽  
Follicle Cells ◽  
Cycle Arrest ◽  
G2 Phase ◽  
G2 Cell Cycle Arrest ◽  
Regulation Of Cell Cycle

Temporal and spatial regulation of cell division is critical for proper development of multicellular organisms. An important aspect of this regulation is cell-cycle arrest, which in many cell types is coupled with differentiated status. Here we report that the polar cells—a group of follicle cells differentiated early during Drosophila oogenesis—are arrested at G2 phase and can serve as a model cell type for investigation of developmental regulation of cell-cycle arrest. On examining the effects of String, a mitosis-promoting phosphatase Cdc25 homolog, and Notch signaling in polar cells, we found that misexpression of String can trigger mitosis in existing polar cells to induce extra polar cells. Normally, differentiation of the polar cells requires Notch signaling. We found that the Notch-induced extra polar cells arise through recruitment of the neighboring cells rather than promotion of proliferation, and they are also arrested at G2 phase. Notch signaling is probably involved in down-regulating String in polar cells, thus inducing the G2 cell-cycle arrest.

scholarly journals Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis inDrosophila melanogaster

Development ◽  
2017 ◽  
Vol 144 (5) ◽  
pp. 905-915 ◽  
Author(s):  
Jay Prakash Shukla ◽  
Girish Deshpande ◽  
L. S. Shashidhara
Keyword(s):  
Notch Signaling ◽  
Binding Protein ◽  
Positive Regulator ◽  
Ataxin 2 ◽  
Context Specific

scholarly journals Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways

Development ◽  
2007 ◽  
Vol 134 (6) ◽  
pp. 1161-1169 ◽  
Author(s):  
E. Assa-Kunik ◽  
I. L. Torres ◽  
E. D. Schejter ◽  
D. S. Johnston ◽  
B.-Z. Shilo
Keyword(s):  
Notch Signaling ◽  
Follicle Cells ◽  
Multiple Levels

JAK signaling is somatically required for follicle cell differentiation inDrosophila

Development ◽  
2002 ◽  
Vol 129 (3) ◽  
pp. 705-717 ◽  
Author(s):  
Jennifer R. McGregor ◽  
Rongwen Xi ◽  
Douglas A. Harrison
Keyword(s):  
Notch Signaling ◽  
Follicle Cell ◽  
Janus Kinase ◽  
Follicle Cells ◽  
Wing Venation ◽  
Vertebrate Development ◽  
Primary Defect ◽  
Pathway Activity ◽  
Polar Cell ◽  
Egg Chambers

Janus kinase (JAK) pathway activity is an integral part of signaling through a variety of ligands and receptors in mammals. The extensive re-utilization and pleiotropy of this pathway in vertebrate development is conserved in other animals as well. In Drosophila melanogaster, JAK signaling has been implicated in embryonic pattern formation, sex determination, larval blood cell development, wing venation, planar polarity in the eye, and formation of other adult structures. Here we describe several roles for JAK signaling in Drosophila oogenesis. The gene for a JAK pathway ligand, unpaired, is expressed specifically in the polar follicle cells, two pairs of somatic cells at the anterior and posterior poles of the developing egg chamber. Consistent with unpaired expression, reduced JAK pathway activity results in the fusion of developing egg chambers. A primary defect of these chambers is the expansion of the polar cell population and concomitant loss of interfollicular stalk cells. These phenotypes are enhanced by reduction of unpaired activity, suggesting that Unpaired is a necessary ligand for the JAK pathway in oogenesis. Mosaic analysis of both JAK pathway transducers, hopscotch and Stat92E, reveals that JAK signaling is specifically required in the somatic follicle cells. Moreover, JAK activity is also necessary for the initial commitment of epithelial follicle cells. Many of these roles are in common with, but distinct from, the known functions of Notch signaling in oogenesis. Consistent with these data is a model in which Notch signaling determines a pool of cells to be competent to adopt stalk or polar fate, while JAK signaling assigns specific identity within that competent pool.

dBrms1 Acts as a Positive Regulator of Notch Signaling in Drosophila Wing

2014 ◽  
Vol 41 (6) ◽  
pp. 317-325 ◽  
Author(s):  
Qinghai Zhang ◽  
Yan Zhang ◽  
Longfei Wu ◽  
Yongfei Yang ◽  
Xue Li ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Positive Regulator ◽  
Drosophila Wing
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