scholarly journals Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis inDrosophila melanogaster

Development ◽  
2017 ◽  
Vol 144 (5) ◽  
pp. 905-915 ◽  
Author(s):  
Jay Prakash Shukla ◽  
Girish Deshpande ◽  
L. S. Shashidhara
Keyword(s):  
Notch Signaling ◽  
Binding Protein ◽  
Positive Regulator ◽  
Ataxin 2 ◽  
Context Specific

scholarly journals CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila

2011 ◽  
Vol 356 (1) ◽  
pp. 128-129
Author(s):  
Elena Domanitskaya ◽  
Trudi Schupbach
Keyword(s):  
Notch Signaling ◽  
Follicle Cells ◽  
Positive Regulator

The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation

2020 ◽  
Vol 528 (4) ◽  
pp. 621-627
Author(s):  
Yasuhiro Arasaki ◽  
Masamichi Li ◽  
Takuro Akiya ◽  
Iori Nozawa ◽  
Yoichi Ezura ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Osteoclast Differentiation ◽  
Rna Binding Protein ◽  
Positive Regulator

scholarly journals Drosophila Ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts

Development ◽  
2010 ◽  
Vol 137 (19) ◽  
pp. 3167-3176 ◽  
Author(s):  
O. Y. Tastan ◽  
J. Z. Maines ◽  
Y. Li ◽  
D. M. Mckearin ◽  
M. Buszczak
Keyword(s):  
Binding Protein ◽  
Intermediate Step ◽  
Molecular Differentiation ◽  
Ataxin 2 ◽  
Female Germline

scholarly journals CO2-Responsive CONSTANS, CONSTANS-Like, and Time of Chlorophyll a/b Binding Protein Expression1 Protein Is a Positive Regulator of Starch Synthesis in Vegetative Organs of Rice

2015 ◽  
Vol 167 (4) ◽  
pp. 1321-1331 ◽  
Author(s):  
Ryutaro Morita ◽  
Miho Sugino ◽  
Tomoko Hatanaka ◽  
Shuji Misoo ◽  
Hiroshi Fukayama
Keyword(s):  
Chlorophyll A ◽  
Binding Protein ◽  
Starch Synthesis ◽  
Vegetative Organs ◽  
Positive Regulator

scholarly journals SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling

2021 ◽  
Vol 14 (689) ◽  
pp. eabe9613
Author(s):  
Nathaniel J. Robinson ◽  
Masaru Miyagi ◽  
Jessica A. Scarborough ◽  
Jacob G. Scott ◽  
Derek J. Taylor ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Intracellular Signaling ◽  
Binding Protein ◽  
Telomere Maintenance ◽  
Nucleocytoplasmic Shuttling ◽  
Iκb Kinase ◽  
Alternative Lengthening ◽  
Telomere Binding Protein ◽  
Sumo Ligase

The maintenance of telomere length supports repetitive cell division and therefore plays a central role in cancer development and progression. Telomeres are extended by either the enzyme telomerase or the alternative lengthening of telomeres (ALT) pathway. Here, we found that the telomere-associated protein SLX4IP dictates telomere proteome composition by recruiting and activating the E3 SUMO ligase PIAS1 to the SLX4 complex. PIAS1 SUMOylated the telomere-binding protein RAP1, which disrupted its interaction with the telomere-binding protein TRF2 and facilitated its nucleocytoplasmic shuttling. In the cytosol, RAP1 bound to IκB kinase (IKK), resulting in activation of the transcription factor NF-κB and its induction of Jagged-1 expression, which promoted Notch signaling and the institution of ALT. This axis could be targeted therapeutically in ALT-driven cancers and in tumor cells that develop resistance to antitelomerase therapies. Our results illuminate the mechanisms underlying SLX4IP-dependent telomere plasticity and demonstrate the role of telomere proteins in directly coordinating intracellular signaling and telomere maintenance dynamics.

scholarly journals Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein

2010 ◽  
Vol 285 (18) ◽  
pp. 13599-13606 ◽  
Author(s):  
Guennadi Kozlov ◽  
Nozhat Safaee ◽  
Angelika Rosenauer ◽  
Kalle Gehring
Keyword(s):  
Binding Protein ◽  
Structural Basis ◽  
Associated Proteins ◽  
Ataxin 2

CoREST acts as a positive regulator of Notch signaling in the follicle cells ofDrosophila melanogaster

Development ◽  
2012 ◽  
Vol 139 (6) ◽  
pp. e608-e608
Author(s):  
E. Domanitskaya ◽  
T. Schupbach
Keyword(s):  
Notch Signaling ◽  
Follicle Cells ◽  
Positive Regulator
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