scholarly journals Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration

Development ◽  
2016 ◽  
Vol 143 (12) ◽  
pp. 2111-2120 ◽  
Author(s):  
Girish Deshpande ◽  
Diane Manry ◽  
Nicholas Jourjine ◽  
Vladic Mogila ◽  
Henny Mozes ◽  
...  
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Abc Transporter ◽  
Hedgehog Signaling ◽  
Germ Cell Migration

zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila

Development ◽  
1998 ◽  
Vol 125 (4) ◽  
pp. 655-666 ◽  
Author(s):  
H.T. Broihier ◽  
L.A. Moore ◽  
M. Van Doren ◽  
S. Newman ◽  
R. Lehmann
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Germ Cells ◽  
Ectopic Expression ◽  
Homeodomain Protein ◽  
Mesoderm Development ◽  
Visceral Mesoderm ◽  
Temporal Course ◽  
Germ Cell Migration

In Drosophila as well as many vertebrate systems, germ cells form extraembryonically and migrate into the embryo before navigating toward gonadal mesodermal cells. How the gonadal mesoderm attracts migratory germ cells is not understood in any system. We have taken a genetic approach to identify genes required for germ cell migration in Drosophila. Here we describe the role of zfh-1 in germ cell migration to the gonadal mesoderm. In zfh-1 mutant embryos, the initial association of germ cells and gonadal mesoderm is blocked. Loss of zfh-1 activity disrupts the development of two distinct mesodermal populations: the caudal visceral mesoderm and the gonadal mesoderm. We demonstrate that the caudal visceral mesoderm facilitates the migration of germ cells from the endoderm to the mesoderm. Zfh-1 is also expressed in the gonadal mesoderm throughout the development of this tissue. Ectopic expression of Zfh-1 is sufficient to induce additional gonadal mesodermal cells and to alter the temporal course of gene expression within these cells. Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1 acts in conjunction with tinman, another homeodomain protein, in the specification of lateral mesodermal derivatives, including the gonadal mesoderm.

scholarly journals Evidence for a role of matrix metalloproteinases and their inhibitors in primordial germ cell migration

Andrology ◽  
2013 ◽  
Vol 1 (5) ◽  
pp. 779-786 ◽  
Author(s):  
A. Díez-Torre ◽  
M. Díaz-Núñez ◽  
C. Eguizábal ◽  
U. Silván ◽  
J. Aréchaga
Keyword(s):  
Cell Migration ◽  
Matrix Metalloproteinases ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Germ Cell Migration

scholarly journals Hedgehog Signaling in Germ Cell Migration

Cell ◽  
2001 ◽  
Vol 106 (6) ◽  
pp. 759-769 ◽  
Author(s):  
Girish Deshpande ◽  
Lisa Swanhart ◽  
Phyllis Chiang ◽  
Paul Schedl
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Hedgehog Signaling ◽  
Germ Cell Migration

scholarly journals The role of cadherins during primordial germ cell migration and early gonad formation in the mouse

2000 ◽  
Vol 91 (1-2) ◽  
pp. 143-152 ◽  
Author(s):  
Michael R Bendel-Stenzel ◽  
Miranda Gomperts ◽  
Robert Anderson ◽  
Janet Heasman ◽  
Christopher Wylie
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Germ Cell Migration

scholarly journals Primordial Germ Cell Migration in the Rat: Preliminary Evidence for a Role of Galactosyltransferase1

2004 ◽  
Vol 71 (6) ◽  
pp. 1822-1827 ◽  
Author(s):  
Soma Bandyopadhyay ◽  
Sutapa Banerjee ◽  
Alok K. Pal ◽  
Sourendra K. Goswami ◽  
Baidyanath Chakravarty ◽  
...  
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Preliminary Evidence ◽  
Germ Cell Migration

scholarly journals ABC-transporter activity and autocrine eicosanoid-signaling are required for germ cell migration a basal chordate

2018 ◽  
Author(s):  
Susannah H. Kassmer ◽  
Delany Rodriguez ◽  
Anthony DeTomaso
Keyword(s):  
Arachidonic Acid ◽  
Cell Migration ◽  
Germ Cell ◽  
Abc Transporter ◽  
Germ Cells ◽  
Signaling Molecules ◽  
Germline Stem Cells ◽  
Colonial Ascidian ◽  
Germ Cell Migration ◽  
12 Lipoxygenase

AbstractIn the colonial ascidian Botryllus schlosseri, long-lived germline stem cells (GSCs) migrate to new germline niches as they develop during repetitive cycles of asexual reproduction. ABC-transporters are involved in the export of lipid-signaling molecules, but their roles in germ cell migration are poorly understood. Here, we show that in Botryllus, abcc1 and abcb1 are highly expressed in germ cells, and inhibition of ABC-transporter activity leads to failure of germ cell migration. Phospholipase A2 (PLA2) produces arachidonic acid, which is further metabolized to eicosanoid signaling molecules. In humans, 12-lipoxygenase (LOX) metabolizes arachidonic acid to12-Hydroxyeicosatetraenoic acid (12-S-HETE), which stimulates migration of mammalian cancer cells and smooth muscle cells. We show that PLA2 and LOX activity are required for germ cell migration. A potential homolog to the human receptor for 12-S-HETE, BSgpr31, is expressed in germ cells. 12-S-HETE rescues migration towards S1P in the presence of inhibitors of ABCC1, ABCB1, PLA2 or LOX, and a gradient of 12-S-HETE enhances chemotaxis towards S1P and stimulates motility. We conclude that 12-S-HETE is a secondary chemoattractant exported by ACB-transporters that is required for migration of germ cells towards S1P. We also find that in the presence of S1P, detection of an 12-S-HETE gradient initiates an autologous positive feedback loop that may sustain migration. This is the first report of an eicosanoid-signaling molecule regulating germ cell migration.

Role of GAGA factor in drosophila primordial germ cell migration and gonad development

2016 ◽  
Vol 47 (1) ◽  
pp. 33-40
Author(s):  
N. V. Dorogova ◽  
A. S. Khrushcheva ◽  
E. V. Fedorova ◽  
A. A. Ogienko ◽  
E. M. Baricheva
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Gonad Development ◽  
Gaga Factor ◽  
Germ Cell Migration

scholarly journals Primordial germ cell migration in the chick and mouse embryo: the role of the chemokine SDF-1/CXCL12

2004 ◽  
Vol 272 (2) ◽  
pp. 351-361 ◽  
Author(s):  
Jürg Stebler ◽  
Derek Spieler ◽  
Krasimir Slanchev ◽  
Kathleen A. Molyneaux ◽  
Ulrike Richter ◽  
...  
Keyword(s):  
Cell Migration ◽  
Germ Cell ◽  
Mouse Embryo ◽  
Primordial Germ Cell ◽  
Germ Cell Migration
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