scholarly journals Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis

Development ◽  
2018 ◽  
Vol 145 (14) ◽  
pp. dev162883 ◽  
Author(s):  
Yuto Watanabe ◽  
Takumi Kawaue ◽  
Takaki Miyata
Keyword(s):  
Progenitor Cells ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

scholarly journals Cephalopod Retinal Development Shows Vertebrate-like Mechanisms of Neurogenesis

2021 ◽  
Author(s):  
Francesca Napoli ◽  
Christina M Daly ◽  
Stephanie Neal ◽  
Kyle J McCulloch ◽  
Alexandra Zaloga ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Progenitor Cells ◽  
Cellular Proliferation ◽  
Imaging Techniques ◽  
Nuclear Migration ◽  
Live Imaging ◽  
Cellular Mechanisms ◽  
High Resolution Data ◽  
Interkinetic Nuclear Migration

Neurogenesis, the regulation of cellular proliferation and differentiation in the developing nervous system, is the process that underlies the diversity of size and cell type found in animal nervous systems. Our understanding of how this process has evolved is limited because of the lack of high resolution data and live-imaging methods across species. The retina is a classic model for the study of neurogenesis in vertebrates and live-imaging of the retina has shown that during development, progenitor cells are organized in a pseudostratified neuroepithelium and nuclei migrate in coordination with the cell cycle along the apicobasal axis of the cell, a process called interkinetic nuclear migration. Eventually cells delaminate and differentiate within the boundaries of the epithelium. This process has been considered unique to vertebrates and thought to be important in maintaining organization during the development of a complex nervous system. Coleoid cephalopods, including squid, cuttlefish and octopus, have the largest nervous system of any invertebrate and convergently-evolved camera-type eyes, making them a compelling comparative system to vertebrates. Here we have pioneered live-imaging techniques to show that the squid, Doryteuthis pealeii, displays cellular mechanisms during cephalopod retinal neurogenesis that are hallmarks of vertebrate processes. We find that retinal progenitor cells in the squid undergo interkinetic nuclear migration until they exit the cell cycle, we identify retinal organization corresponding to progenitor, post-mitotic and differentiated cells, and we find that Notch signaling regulates this process. With cephalopods and vertebrates having diverged 550 million years ago, these results suggest that mechanisms thought to be unique to vertebrates may be common to highly proliferative neurogenic primordia contributing to a large nervous system.

Rac is involved in the interkinetic nuclear migration of cortical progenitor cells

2009 ◽  
Vol 63 (4) ◽  
pp. 294-301 ◽  
Author(s):  
Sayaka Minobe ◽  
Akira Sakakibara ◽  
Tomoko Ohdachi ◽  
Rieko Kanda ◽  
Miyako Kimura ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration ◽  
Cortical Progenitor

Ninein is essential for the interkinetic nuclear migration of cortical progenitor cells anchoring the centrosome to microtubules

2011 ◽  
Vol 71 ◽  
pp. e231
Author(s):  
Hiroshi Shinohahra ◽  
Nobuyuki Sakayori ◽  
Masanori Takahashi ◽  
Tatsunori Seki ◽  
Noriko Osumi
Keyword(s):  
Progenitor Cells ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration ◽  
Cortical Progenitor

A role for CK2 upon interkinetic nuclear migration in the cell cycle of retinal progenitor cells

2008 ◽  
Vol 68 (5) ◽  
pp. 620-631 ◽  
Author(s):  
Ana Carolina Dudenhoeffer Carneiro ◽  
Lucianne Fragel-Madeira ◽  
Mario Alberto Silva-Neto ◽  
Rafael Linden
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Nuclear Migration ◽  
Retinal Progenitor Cells ◽  
Retinal Progenitor ◽  
Interkinetic Nuclear Migration

Interkinetic nuclear migration in the tracheal and esophageal epithelia of the mouse embryo: Possible implications for tracheo-esophageal anomalies

2017 ◽  
Vol 58 (2) ◽  
pp. 62-70 ◽  
Author(s):  
Ryo Kaneda ◽  
Yuko Saeki ◽  
Dereje Getachew ◽  
Akihiro Matsumoto ◽  
Motohide Furuya ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

scholarly journals Interkinetic nuclear migration, cell polarity, and retinal neurogenesis

2010 ◽  
Vol 7 (15) ◽  
pp. 30-30
Author(s):  
B. Link ◽  
S. Cui ◽  
L. Baye
Keyword(s):  
Cell Polarity ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration ◽  
Retinal Neurogenesis

scholarly journals Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors

2010 ◽  
Vol 30 (12) ◽  
pp. 4197-4209 ◽  
Author(s):  
X. Liu ◽  
K. Hashimoto-Torii ◽  
M. Torii ◽  
C. Ding ◽  
P. Rakic
Keyword(s):  
Gap Junctions ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

Global pattern of interkinetic nuclear migration in tracheoesophageal epithelia of the mouse embryo: Interorgan and intraorgan regional differences

2020 ◽  
Author(s):  
Dereje Getachew ◽  
Akihiro Matsumoto ◽  
Yasuhiro Uchimura ◽  
Jun Udagawa ◽  
Nanako Mita ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Regional Differences ◽  
Nuclear Migration ◽  
Global Pattern ◽  
Interkinetic Nuclear Migration

scholarly journals Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

2011 ◽  
Vol 30 (9) ◽  
pp. 1690-1704 ◽  
Author(s):  
Yoichi Kosodo ◽  
Taeko Suetsugu ◽  
Masumi Suda ◽  
Yuko Mimori-Kiyosue ◽  
Kazunori Toida ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Migration ◽  
Developing Brain ◽  
Interkinetic Nuclear Migration
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