scholarly journals Upregulation of Protein Tyrosine Phosphatase Type IVA Member 3 (PTP4A3/PRL-3) is Associated with Tumor Differentiation and a Poor Prognosis in Human Hepatocellular Carcinoma

2012 ◽  
Vol 20 (1) ◽  
pp. 305-317 ◽  
Author(s):  
Abudureheman Mayinuer ◽  
Mahmut Yasen ◽  
Kaoru Mogushi ◽  
Gulanbar Obulhasim ◽  
Maimaiti Xieraili ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Tyrosine Phosphatase ◽  
Poor Prognosis ◽  
Tyrosine Phosphatase ◽  
Human Hepatocellular Carcinoma ◽  
Tumor Differentiation ◽  
Protein Tyrosine

scholarly journals IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma

2020 ◽  
Vol 8 (1) ◽  
pp. e000285 ◽  
Author(s):  
Wenjie Zhang ◽  
Yang Liu ◽  
Zhongyi Yan ◽  
Hui Yang ◽  
Wei Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Human Hepatocellular Carcinoma ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Post Surgery ◽  
Monocytes And Macrophages

BackgroundWe have previously discovered a relationship between the low expression of protein tyrosine phosphatase, receptor type O (PTPRO) in tumor-infiltrating T cells and immunosuppression. The aim of the present study was to investigate the relationship between decreased PTPRO and increased programmed death ligand 1 (PD-L1) in both the peripheral monocytes and tumor-infiltrating macrophages of human hepatocellular carcinoma (HCC).MethodsThe expression and correlation of all the indices were explored in monocytes and tumor-infiltrating macrophages within both human and mice HCC. The mechanic regulations were studied by using both in vitro and in vivo studies.ResultsWe found a significant decrease in PTPRO in HCC peripheral monocytes that was associated with increased PD-L1 expression in peripheral monocytes and tumor-associated macrophages (TAMs) in HCC. Monocyte PD-L1 and PTPRO therefore could serve as valuable prognostic indicators for post-surgery patients with HCC and were associated with increased T-cell exhaustion (Tim3+T cells). A depletion of PTPRO promoted PD-L1 secretion in both monocytes and macrophages through the JAK2/STAT1 and JAK2/STAT3/c-MYC pathways. Increased IL-6 expression was associated with activation of JAK2/STAT3/c-MYC and with decreased PTPRO expression through the STAT3/c-MYC/miR-25–3 p axis. Monocytes and TAMs showed significantly increased miR-25–3 p expression, which could target the 3′ untranslated region of PTPRO. The miR-25–3 p expression positively correlated with serum IL-6 levels, but inversely correlated with PTPRO in HCC monocytes. IL-6/STAT3/c-MYC activation enhanced in vitro miR-25–3 p transcription and decreased PTPRO, while further promoting PD-L1 secretion. Adoptive cell transfer of c-MYC/miR-25–3 p–modified monocytes promoted tumor growth by downregulating PTPRO and causing a PD-L1–induced immunosuppression in an orthotopic tumor transplantation model.ConclusionsIncreased serum IL-6 downregulated PTPRO expression in HCC monocytes and macrophages by activating STAT3/c-MYC/miR-25–3 p and by further enhancing PD-L1 expression through JAK2/STAT1 and JAK2/STAT3/c-MYC signaling.

scholarly journals Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma

Oncogene ◽  
2003 ◽  
Vol 22 (30) ◽  
pp. 4656-4663 ◽  
Author(s):  
Hidenobu Nagano ◽  
Tetsuya Noguchi ◽  
Kenjiro Inagaki ◽  
Seitetsu Yoon ◽  
Takashi Matozaki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stomach Cancer ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Human Hepatocellular Carcinoma ◽  
Protein Tyrosine

Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma

1994 ◽  
Vol 29 (6) ◽  
pp. 727-732 ◽  
Author(s):  
Shigeo Ikuta ◽  
Fumio Itoh ◽  
Yuji Hinoda ◽  
Minoru Toyota ◽  
Yusuke Makiguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Human Hepatocellular Carcinoma ◽  
Protein Tyrosine

scholarly journals Protein tyrosine phosphatase 1B dephosphorylates PITX1 and regulates p120RasGAP in hepatocellular carcinoma

Hepatology ◽  
2016 ◽  
Vol 63 (5) ◽  
pp. 1528-1543 ◽  
Author(s):  
Wei-Tien Tai ◽  
Yao-Li Chen ◽  
Pei-Yi Chu ◽  
Li-Ju Chen ◽  
Man-Hsin Hung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine
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