Synthesis of β-Hydroxy-α,α-disubstituted Amino Acids through the Orthoamide-Type Overman Rearrangement of an α,β-Unsaturated Ester and Stereodivergent Intramolecular SN2′ Reaction: Development and Application to the Total Synthesis of Sphingofungin F

2018 ◽  
Vol 91 (4) ◽  
pp. 594-607 ◽  
Author(s):  
Tomoya Sugai ◽  
Shunme Usui ◽  
Shun Tsuzaki ◽  
Hiroki Oishi ◽  
Daichi Yasushima ◽  
...  
Keyword(s):  
Amino Acids ◽  
Total Synthesis ◽  
Unsaturated Ester ◽  
Sn2 Reaction ◽  
Disubstituted Amino Acids

Total Synthesis of (±)-α- and β-Lycoranes by Sequential Chemoselective Conjugate Addition−Stereoselective Nitro-Michael Cyclization of an ω-Nitro-α,β,ψ,ω-unsaturated Ester

2003 ◽  
Vol 5 (7) ◽  
pp. 1123-1126 ◽  
Author(s):  
Tomohisa Yasuhara ◽  
Katsumi Nishimura ◽  
Mitsuaki Yamashita ◽  
Naoshi Fukuyama ◽  
Ken-ichi Yamada ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Conjugate Addition ◽  
Unsaturated Ester

scholarly journals New cyclization reactions in organic syntheses

2002 ◽  
Vol 74 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Iwao Ojima
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Total Synthesis ◽  
Cyclization Reactions ◽  
Organic Syntheses ◽  
Carbocyclic Compounds ◽  
Efficient Construction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Recent development in the transition metal-catalyzed cyclization reactions for organic syntheses in the author's laboratories is summarized, which includes (i) novel silylcarbocyclizations (SiCaCs) and carbonylative carbotricyclizations, (ii) intramolecular silylformylations and desymmerization of siloxydiynes by sequential double silylformylation, (iii) efficient total synthesis of (+)-prosopinine, (iv) enantioselective desymmetrization of aminodienes, and (iv) new and efficient routes to 1-azabicyclo[x.y.0]alkane amino acids. All these processes are catalyzed by Rh or Rh­Co complexes, and useful for rapid and efficient construction of a variety of heterocyclic and carbocyclic compounds. Mechanisms of these new carbocyclization and cyclohydrocarbonylation reactions are also discussed.

Synthesis of a series of “cationic”, orthogonally protected, α, α-disubstituted amino acids

2005 ◽  
pp. 329-330
Author(s):  
T. S. Yokum ◽  
M. G. Bursavich ◽  
S. A. Piha-Paul ◽  
D. A. Hall ◽  
M. L. McLaughlin
Keyword(s):  
Amino Acids ◽  
Disubstituted Amino Acids

ChemInform Abstract: Stereoselective Total Synthesis of Topographically Constrained Designer Amino Acids: 2′,6′-Dimethyl-β-methyltyrosines.

ChemInform ◽  
2010 ◽  
Vol 26 (29) ◽  
pp. no-no
Author(s):  
X. QIAN ◽  
K. C. RUSSELL ◽  
L. W. BOTEJU ◽  
V. J. HRUBY
Keyword(s):  
Amino Acids ◽  
Total Synthesis

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters

2017 ◽  
Vol 25 (6) ◽  
pp. 1846-1851 ◽  
Author(s):  
Hiroko Yamashita ◽  
Takashi Misawa ◽  
Makoto Oba ◽  
Masakazu Tanaka ◽  
Mikihiko Naito ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Disubstituted Amino Acids
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