scholarly journals Electrochemical Behavior of Ferredoxins Adsorbed on Mercury Electrode Surface. Cyclic d.c. and a.c. Voltammetric Studies with Hanging Mercury Drop Electrode

1979 ◽  
Vol 52 (7) ◽  
pp. 1937-1943 ◽  
Author(s):  
Tokuji Ikeda ◽  
Kazunobu Toriyama ◽  
Mitsugi Senda
Keyword(s):  
Electrochemical Behavior ◽  
Electrode Surface ◽  
Mercury Electrode ◽  
Hanging Mercury Drop Electrode ◽  
Mercury Drop Electrode ◽  
Voltammetric Studies

Voltammetric behavior and quantification of the anti-leukemia drug imatinib in bulk form, pharmaceutical formulation, and human serum at a mercury electrode

2004 ◽  
Vol 82 (7) ◽  
pp. 1203-1209 ◽  
Author(s):  
E Hammam ◽  
H S El-Desoky ◽  
A Tawfik ◽  
M M Ghoneim
Keyword(s):  
Cyclic Voltammetry ◽  
Human Serum ◽  
Electrochemical Behavior ◽  
Stripping Voltammetry ◽  
Pharmaceutical Formulation ◽  
Myelogenous Leukemia ◽  
Hanging Mercury Drop Electrode ◽  
Square Wave ◽  
Mercury Drop Electrode ◽  
Square Wave Stripping Voltammetry

Imatinib (GleevecTM, ST1571) exemplifies the successful development of a rationally designed molecularly targeted therapy for treatment of a specific cancer. It is a highly promising new drug for the treatment of chronic myelogenous leukemia in blast crisis, in the accelerated or chronic phase after interferon failure or intolerance. The electrochemical behavior of imatinib was studied in Britton–Robinson (B–R) buffers of pH 2 to 11 by means of cyclic voltammetry at a hanging mercury drop electrode. The voltammograms showed a single 2-electron irreversible cathodic peak, which may be attributed to reduction of the C=O double bond of the imatinib molecule. Imatinib exhibited a strong adsorption onto the electrode surface especially in B–R buffers of pH 6 and 7. The adsorptive response of the drug was optimized with respect to the pH of the electrolysis medium, accumulation variables, and instrumental parameters using a square-wave stripping voltammetry technique. A fully validated, simple, sensitive, precise, and selective square-wave adsorptive cathodic stripping voltammetric procedure is described for trace determination of imatinib. The limits of detection (LOD) and quantitation (LOQ) of the bulk imatinib, following preconcentration for 150 s onto the hanging mercury drop electrode, were found to be 2.6 × 10–10 and 8.7 × 10–10 mol/L, respectively. The proposed procedure was successfully applied for quantitation of imatinib in pharmaceutical formulation (Glivec®) and spiked human serum, without the necessity for sample pretreatment or time-consuming extraction or evaporation steps prior to analysis of the drug. LOD and LOQ of 4.6 × 10–10 and 1.5 × 10–9 mol/L, respectively, were achieved after 120 s of preconcentration of the drug spiked in human serum.Key words: imatinib, GleevecTM, Glivec®, ST1571, cyclic voltammetry, square-wave stripping voltammetry, electrochemical behavior, quantification, pharmaceutical formulation, human serum.

Polarographic determination of azobenzene

1986 ◽  
Vol 51 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Jiří Barek ◽  
Roman Hrnčíř
Keyword(s):  
Detection Limit ◽  
Electrode Surface ◽  
Linear Sweep Voltammetry ◽  
Polarographic Determination ◽  
Hanging Mercury Drop Electrode ◽  
Linear Sweep ◽  
Aqueous Methanol ◽  
Mercury Drop Electrode

Conditions were found for the determination of azobenzene by means of DC, AC, TAST, DP, and FSDP polarography and linear sweep voltammetry on a hanging mercury drop electrode in the medium of aqueous methanol, which ensures a sufficient solubility of azobenzene. In the latter two methods, the detection limit was around 10-8 mol/l; a still lower value could be attained by preliminary accumulation of azobenzene, i.e. adsorption on the electrode surface.

Polarographic and Voltammetric Determination of N,N-Dimethyl-4-amino-4'-sulfoazobenzene

1997 ◽  
Vol 62 (4) ◽  
pp. 597-608 ◽  
Author(s):  
Jiří Barek ◽  
Pham Tuan Hai ◽  
Viktor Mejstřík ◽  
Josino C. Moreira ◽  
Jiří Zima
Keyword(s):  
Mercury Electrode ◽  
Differential Pulse ◽  
Differential Pulse Polarography ◽  
Test Substance ◽  
Hanging Mercury Drop Electrode ◽  
Large Area ◽  
Mercury Drop Electrode ◽  
Pulse Polarography ◽  
Dropping Mercury Electrode ◽  
Constant Potential

The polarographic behaviour of N,N-dimethyl-4-amino-4'-sulfoazobenzene was investigated by tast polarography and differential pulse polarography at a dropping mercury electrode, constant-potential coulometry at a large area mercury electrode and cyclic voltammetry at a hanging mercury drop electrode. Optimum conditions have been found for its determination by tast polarography in the concentration range of 2-100 μmol l-1, differential pulse polarography at a dropping mercury electrode in the concentration range of 0.2-100 μmol l-1 and by differential pulse voltammetry at a hanging mercury drop electrode in the concentration range of 0.02-10 μmol l-1. The sensitivity of the determination can be further improved by adsorptive accumulation of the test substance on the hanging mercury drop electrode. Three-minute accumulation in stirred solution allows determination in the range of 0.2-100 nmol l-1.

Electrochemical behavior of 7-deazaguanine- and 7-deazaadenine-modified DNA at the hanging mercury drop electrode

2015 ◽  
Vol 147 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Zdenka Dudová ◽  
Jan Špaček ◽  
Martin Tomaško ◽  
Luděk Havran ◽  
Hana Pivoňková ◽  
...  
Keyword(s):  
Electrochemical Behavior ◽  
Hanging Mercury Drop Electrode ◽  
Mercury Drop Electrode ◽  
Modified Dna

The Polarographic and Voltammetric Determination of N,N-Dimethyl-4-amino-3'-nitroazobenzene

1993 ◽  
Vol 58 (2) ◽  
pp. 295-309 ◽  
Author(s):  
Jiří Barek ◽  
Dana Dřevínková ◽  
Viktor Mejstřík ◽  
Jiří Zima
Keyword(s):  
Mercury Electrode ◽  
Differential Pulse ◽  
Differential Pulse Polarography ◽  
Test Substance ◽  
Polarographic Reduction ◽  
Hanging Mercury Drop Electrode ◽  
Mercury Drop Electrode ◽  
Pulse Polarography ◽  
Dropping Mercury Electrode

The polarographic reduction of N,N-dimethyl-4-amino-3'-nitroazobenzene was studied by tast polarography and differential pulse polarography, constant potential coulometry and cyclic voltammetry and mechanism was proposed for the reduction. Optimal conditions were found for the determination of the test substance using tast polarography in concentration range 1 . 10-4 - 2 . 10-6 mol l-1, differential pulse polarography at classical dropping mercury electrode and fast scan differential pulse voltammetry at a hanging mercury drop electrode in range 1 . 10-4 - 2 . 10-7 mol l-1 and linear scan voltammetry at a hanging mercury drop electrode in range 1 . 10-5 - 2 . 10-8 mol l-1. A further increase in the sensitivity was achieved through adsorptive accumulation of the test substance on the surface of the working electrode, permitting the determination to be carried out in the concentration range 1 . 10-7 - 2 . 10-9 mol l-1.

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