Voltammetric behavior and quantification of the anti-leukemia drug imatinib in bulk form, pharmaceutical formulation, and human serum at a mercury electrode

2004 ◽  
Vol 82 (7) ◽  
pp. 1203-1209 ◽  
Author(s):  
E Hammam ◽  
H S El-Desoky ◽  
A Tawfik ◽  
M M Ghoneim
Keyword(s):  
Cyclic Voltammetry ◽  
Human Serum ◽  
Electrochemical Behavior ◽  
Stripping Voltammetry ◽  
Pharmaceutical Formulation ◽  
Myelogenous Leukemia ◽  
Hanging Mercury Drop Electrode ◽  
Square Wave ◽  
Mercury Drop Electrode ◽  
Square Wave Stripping Voltammetry

Imatinib (GleevecTM, ST1571) exemplifies the successful development of a rationally designed molecularly targeted therapy for treatment of a specific cancer. It is a highly promising new drug for the treatment of chronic myelogenous leukemia in blast crisis, in the accelerated or chronic phase after interferon failure or intolerance. The electrochemical behavior of imatinib was studied in Britton–Robinson (B–R) buffers of pH 2 to 11 by means of cyclic voltammetry at a hanging mercury drop electrode. The voltammograms showed a single 2-electron irreversible cathodic peak, which may be attributed to reduction of the C=O double bond of the imatinib molecule. Imatinib exhibited a strong adsorption onto the electrode surface especially in B–R buffers of pH 6 and 7. The adsorptive response of the drug was optimized with respect to the pH of the electrolysis medium, accumulation variables, and instrumental parameters using a square-wave stripping voltammetry technique. A fully validated, simple, sensitive, precise, and selective square-wave adsorptive cathodic stripping voltammetric procedure is described for trace determination of imatinib. The limits of detection (LOD) and quantitation (LOQ) of the bulk imatinib, following preconcentration for 150 s onto the hanging mercury drop electrode, were found to be 2.6 × 10–10 and 8.7 × 10–10 mol/L, respectively. The proposed procedure was successfully applied for quantitation of imatinib in pharmaceutical formulation (Glivec®) and spiked human serum, without the necessity for sample pretreatment or time-consuming extraction or evaporation steps prior to analysis of the drug. LOD and LOQ of 4.6 × 10–10 and 1.5 × 10–9 mol/L, respectively, were achieved after 120 s of preconcentration of the drug spiked in human serum.Key words: imatinib, GleevecTM, Glivec®, ST1571, cyclic voltammetry, square-wave stripping voltammetry, electrochemical behavior, quantification, pharmaceutical formulation, human serum.

scholarly journals Adsorptive stripping voltammetric determination of the anti-inflammatory drug tolmetin in bulk form, pharmaceutical formulation and human serum

2007 ◽  
Vol 5 (3) ◽  
Author(s):  
Amr Beltagi ◽  
Mona El-Attar ◽  
Enass Ghoneim
Keyword(s):  
Human Serum ◽  
Mercury Electrode ◽  
Direct Determination ◽  
Stripping Voltammetry ◽  
Pharmaceutical Formulation ◽  
Analyte Molecule ◽  
Square Wave ◽  
Limit Of Quantitation ◽  
Square Wave Stripping Voltammetry

AbstractThe electro-reduction of tolmetin at the hanging mercury drop electrode was studied in different supporting electrolytes using cyclic voltammetry and square-wave stripping voltammetry techniques. Voltammograms of tolmetin exhibited a single well-defined 2-electron irreversible cathodic peak in media of pH C=O double bond of the analyte molecule. Adsorption of tolmetin onto the surface of the hanging mercury electrode was identified and each adsorbed tolmetin molecule was found to occupy an area of 0.23 nm2. A square-wave adsorptive cathodic stripping voltammetric procedure was described for the direct determination of tolmetin in bulk form and pharmaceutical formulation (Rumatol® capsules) with a limit of quantitation of 2 × 10−9 M and a mean percentage recovery of 98.35 ± 1.21% to 99.57 ± 1.23. Moreover, the described procedure was successfully applied for the direct assay of tolmetin in spiked human serum without pretreatment or extraction prior to the analysis while a quantitation limit of 5 × 10−9 M tolmetin was achieved.

Three validated stripping voltammetric procedures for determination of the anti-prostate cancer drug flutamide in tablets and human serum at a mercury electrode

2004 ◽  
Vol 82 (9) ◽  
pp. 1386-1392 ◽  
Author(s):  
E Hammam ◽  
H S El-Desoky ◽  
K Y El-Baradie ◽  
A M Beltagi
Keyword(s):  
Prostate Cancer ◽  
Human Serum ◽  
Mercury Electrode ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Pharmaceutical Formulation ◽  
Cancer Drug ◽  
Linear Sweep ◽  
Square Wave

Flutamide is a nonsteriodal anti-androgen drug, which is commonly used in the treatment of advanced prostate cancer. Based on the reduction of the nitro organic moiety of the drug molecule in acetate buffer of pH 5 at the hanging mercury drop electrode, three adsorptive cathodic stripping voltammetric procedures were optimized for determination of flutamide in bulk, tablets, and human serum applying linear-sweep, differential-pulse, and square-wave waveforms. The achieved limits of detection of the bulk drug were 1.9 × 10–7, 8.7 × 10–8, and 9.7 × 10–9 mol L–1 by using the optimized differential-pulse, linear-sweep, and square-wave adsorptive stripping voltammetric procedures, respectively. Repeatability of the results was studied for 1 × 10–6 mol L–1 of the drug and the recoveries obtained were 98.51 ± 1.56% (LSV), 98.89 ± 0.87% (DPV), and 99.21 ± 1.03% (SWV). The proposed procedures were successfully applied to the determination of the drug in pharmaceutical formulation (Eulexin® tablets) and human serum. The detection limits of the drug in bulk, pharmaceutical formulation, and human serum achieved by means of the proposed procedures showed that the square-wave mode was more reliable for determination of the drug especially in its low concentration levels.Key words: flutamide, linear-sweep, differential-pulse, square-wave, cathodic adsorptive stripping voltammetry, determination, Eulexin® tablets, human serum.

Anodic oxidation of mercury in the presence of thioether acids: Methane-1,1-bis-mercaptoacetic acid

1987 ◽  
Vol 52 (3) ◽  
pp. 616-625 ◽  
Author(s):  
E. Casassas ◽  
M. Esteban ◽  
C. Ariño
Keyword(s):  
Cyclic Voltammetry ◽  
Anodic Oxidation ◽  
Stripping Voltammetry ◽  
Electrode Process ◽  
Mercaptoacetic Acid ◽  
Anodic Process ◽  
Hanging Mercury Drop Electrode ◽  
No Adsorption ◽  
Cathodic Stripping Voltammetry ◽  
Mercury Drop Electrode

The anodic oxidation of mercury in the presence of methane-1,1-bis-mercaptoacetic acid (MBMA) has been studied by DCr, DP, AC1, and AC2 polarography, cyclic voltammetry, and coulometry. The electrode process is controlled by the adsorption of the product formed according to: Hg + 2 H(2-n)Ln- → H(2-n)HgL2n- + (2-n) H+ + 2e with n = 0 at pH < pK1, n = 1 at pK1 < pH < pK2, and n = 2 at pH > pK2. No adsorption of MBMA is observed. The behaviour of MBMA at a hanging mercury drop electrode (HMDE) by cathodic stripping voltammetry (CSV) has been also studied. At MBMA concentrations above 1 10-6 mol l-1, the stripping voltammograms showed two well defined peaks, at c. -0.140 V and at c. -0.300 V. The anodic process occurring during the pre-electrolysis in CSV is described by the formation of a Hg(I) compound: 2 Hg + 2 H(2-n)Ln- → H(2-n)Hg2L2(2-2n)+ + 2e followed by its disproportionation: H(2-n)Hg2L2(2-2n)+ →c H(2-n)HgL2(2-2n)+ + Hg,where n has the above-mentioned values.

Pb Detection in Soil Samples by Electroanalysis: Cyclic Voltammetry and Osteryoung Square Wave Stripping Voltammetry

2019 ◽  
Vol 15 (1) ◽  
pp. 527-533
Author(s):  
Gabriela Beristain-Ortiz ◽  
Emgdia G. Sumbarda Ramos ◽  
M. G. Garcia ◽  
Mercedes T. Oropeza
Keyword(s):  
Cyclic Voltammetry ◽  
Stripping Voltammetry ◽  
Soil Samples ◽  
Square Wave ◽  
Square Wave Stripping Voltammetry

Analysis of trace nickel by square wave stripping voltammetry using chloropalladium(II) complex-modified MWCNTs paste electrode

2017 ◽  
Vol 240 ◽  
pp. 848-856 ◽  
Author(s):  
Mohamad Idris Saidin ◽  
Illyas Md Isa ◽  
Mustaffa Ahmad ◽  
Norhayati Hashim ◽  
Sulaiman Ab Ghani
Keyword(s):  
Stripping Voltammetry ◽  
Square Wave ◽  
Square Wave Stripping Voltammetry ◽  
Paste Electrode

scholarly journals Anodic Stripping Voltammetry with the Hanging Mercury Drop Electrode for Trace Metal Detection in Soil Samples

Chemosensors ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 107
Author(s):  
Kequan Xu ◽  
Clara Pérez-Ràfols ◽  
Amine Marchoud ◽  
María Cuartero ◽  
Gastón A. Crespo
Keyword(s):  
Metal Ions ◽  
Limit Of Detection ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Hanging Mercury Drop Electrode ◽  
Mercury Drop Electrode ◽  
Redox Active ◽  
Active Metal ◽  
Metal Detection ◽  
Trace Metal Detection

The widely spread use of the hanging mercury drop electrode (HMDE) for multi-ion analysis is primarily ascribed to the following reasons: (i) excellent reproducibility owing to the easy renewal of the electrode surface avoiding any hysteresis effect (i.e., a new identical drop is generated for each measurement to be accomplished); (ii) a wide cathodic potential window originating from the passive hydrogen evolution and solvent electrolysis; (iii) the ability to form amalgams with many redox-active metal ions; and (iv) the achievement of (sub)nanomolar limits of detection. On the other hand, the main controversy of the HMDE usage is the high toxicity level of mercury, which has motivated the scientific community to question whether the HMDE deserves to continue being used despite its unique capability for multi-metal detection. In this work, the simultaneous determination of Zn2+, Cd2+, Pb2+, and Cu2+ using the HMDE is investigated as a model system to evaluate the main features of the technique. The analytical benefits of the HMDE in terms of linear range of response, reproducibility, limit of detection, proximity to ideal redox behavior of metal ions and analysis time are herein demonstrated and compared to other electrodes proposed in the literature as less-toxic alternatives to the HMDE. The results have revealed that the HMDE is largely superior to other reported methods in several aspects and, moreover, it displays excellent accuracy when simultaneously analyzing Zn2+, Cd2+, Pb2+, and Cu2+ in such a complex matrix as digested soils. Yet, more efforts are required towards the definitive replacement of the HMDE in the electroanalysis field, despite the elegant approaches already reported in the literature.

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