New and Efficient Synthesis of Oligomeric PorphyrinsviaStepwise Nucleophilic Substitution of Aminoporphyrins to Cyanuric Chloride

1995 ◽  
Vol 24 (8) ◽  
pp. 631-632 ◽  
Author(s):  
Kanako Ichihara ◽  
Yoshinori Naruta
Keyword(s):  
Nucleophilic Substitution ◽  
Cyanuric Chloride ◽  
Efficient Synthesis

scholarly journals A new and efficient protocol for the synthesis of the key intermediate of Palbociclib

2019 ◽  
Vol 43 (1-2) ◽  
pp. 14-19
Author(s):  
Shuting Li ◽  
Wanfeng Yang ◽  
Min Ji ◽  
Jin Cai ◽  
Junqing Chen
Keyword(s):  
Nucleophilic Substitution ◽  
Heck Reaction ◽  
Ring Closure ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Synthetic Strategy

A new and efficient synthesis of 6-bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)-pyrido[2,3-d]pyrimidin-7(8H)-one, a key intermediate of Palbociclib, starting from thiouracil was described. This protocol involved methylation, nucleophilic substitution, bromination, nucleophilic substitution, Heck reaction, ring closure, oxidation, and bromination to afford a key intermediate of Palbociclib with approximately 35% overall yield. The advantages of this developed synthetic strategy included improved overall yield, inexpensive starting materials, and readily controllable and cleaner reaction conditions.

Easy Access to Isomeric 7-Deazapurine–1,2,3-Triazole Conjugates via SNAr and CuAAC Reactions of 2,6-Diazido-7-deazapurines

Synlett ◽  
2017 ◽  
Vol 29 (04) ◽  
pp. 525-529 ◽  
Author(s):  
Sigitas Tumkevicius ◽  
Jonas Bucevicius ◽  
Maris Turks
Keyword(s):  
Nucleophilic Substitution ◽  
Easy Access ◽  
Efficient Synthesis ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions

A simple and efficient synthesis of isomeric 7-deazapurine–1,2,3-triazole conjugates with amino substituents from readily available 9-alkyl-2,6-diazido-7-deazapurines has been developed using consecutive CuAAC and regioselective nucleophilic substitution reactions of ­azido and 1,2,3-triazole groups with amines.

Wet cyanuric chloride catalyzed simple and efficient synthesis of 14-aryl or alkyl-14-H-dibenzo[a,j]xanthenes

2007 ◽  
Vol 8 (11) ◽  
pp. 1595-1598 ◽  
Author(s):  
Mohammad A. Bigdeli ◽  
Majid M. Heravi ◽  
Gholam Hossein Mahdavinia
Keyword(s):  
Cyanuric Chloride ◽  
Efficient Synthesis

An insight study into the parameters altering the emission of a covalent triazine framework

2021 ◽  
Author(s):  
Panagiota Bika ◽  
Vitaly Osokin ◽  
Tatiana Giannakopoulou ◽  
Nadia Todorova ◽  
Mo Li ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Band Gap ◽  
Fluorescent Sensors ◽  
Cyanuric Chloride ◽  
Covalent Triazine Framework

Covalent triazine frameworks (CTFs) synthesized through nucleophilic substitution of 4,4’ bipyridine on the carbon atoms of cyanuric chloride were studied as fluorescent sensors. The band gap of the materials was...

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