Synthesis of Cyanuric Chloride based Chiral Reagent for RP-HPLC Enantioseparation of (RS)-Propranolol

In this work, four cyanuric chloride based chiral reagents were prepared via nucleophile substitution of chlorine atom by L-proline derivatives and characterized by UV, FT-IR, HRMS, NMR and elemental analysis. Racemic propranolol was chosen for the chiral recognition study. The prepared chiral reagents were used in the synthesis of diastereomeric derivatives of (RS)-propranolol, under microwave heating conditions. RP-HPLC was used to separate the prepared diastereomeric derivatives. The effect of varying eluting phase concentrations and sample concentrations was optimized. The DFT calculations were performed using Gaussian 09 Rev A.02 to create the lowest energy optimised structures of diastereomeric derivatives. LOD (0.324 ng mL-1), LOQ (0.972 ng mL-1), calibration range (0.02-2.0 mg mL-1), correlation-coefficient (0.999), and recovery were the validation parameters for the present method (99.09 and 99.81 % for inter-day assay and 98.47 and 99.72 % for intra-day assay).

An insight study into the parameters altering the emission of a covalent triazine framework

Covalent triazine frameworks (CTFs) synthesized through nucleophilic substitution of 4,4’ bipyridine on the carbon atoms of cyanuric chloride were studied as fluorescent sensors. The band gap of the materials was...

The synthesis of conjugated microporous polymers via nucleophilic substitution of hydroquinone with cyanuric chloride and hexachlorocyclotriphosphazene for sensing to 2,4-dinitrophenol and 2,4,6-trinitrophenol

Hydroquinone is an electron-rich connector similar in structure to DNP and TNP. Two hydroquinone-based conjugated microporous polymers have excellent fluorescence sensing performance for DNP and TNP, respectively.