scholarly journals Inhibitory Effect of Juniperonic Acid (Δ-5c,11c,14c,17c-20:4, ω-3) on Bombesin-Induced Proliferation of Swiss 3T3 Cells

2008 ◽  
Vol 31 (9) ◽  
pp. 1786-1789 ◽  
Author(s):  
Jun-ichi Morishige ◽  
Naoki Amano ◽  
Kaoru Hirano ◽  
Hiroaki Nishio ◽  
Tamotsu Tanaka ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
3T3 Cells ◽  
Juniperonic Acid ◽  
Swiss 3T3

scholarly journals Inhibition of the binding of 125I-labelled epidermal growth factor to mouse cells by a mitogen in goat mammary secretions

1983 ◽  
Vol 212 (2) ◽  
pp. 465-472 ◽  
Author(s):  
K D Brown ◽  
D M Blakeley
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egf Receptor ◽  
Competitive Inhibitor ◽  
Inhibitory Effect ◽  
Temperature Sensitive ◽  
Egf Receptors ◽  
3T3 Cells ◽  
Epidermal Growth ◽  
Swiss 3T3

Pre-colostrum and colostrum from goats cause a marked inhibition of the binding of 125I-labelled epidermal growth factor (125I-EGF) to Swiss 3T3 cells. The ability of these secretions to inhibit 125I-EGF binding is closely correlated with the ability to stimulate DNA synthesis in quiescent 3T3 cell cultures, suggesting that goat mammary secretions may contain an EGF-related mitogen. However, the material in colostrum which inhibits 125I-EGF binding to Swiss 3T3 cells is a basic protein with Mr greater than 20000 and is thus quite different from mouse and human EGF. Furthermore, the colostral-mediated inhibition of 125I-EGF binding, although rapid and apparently competitive, differs from the inhibition of binding induced by native, unlabelled EGF. Thus, the inhibitory effect of colostrum is markedly decreased when the assay temperature is shifted from 37 degrees C to 4 degrees C whereas unlabelled EGF is an effective competitive inhibitor at both 37 degrees C and 4 degrees C. Incubation of cells with EGF causes a reduction in cell surface EGF receptors whereas exposure to colostrum does not induce down-regulation of the EGF receptor. Our results suggest that the colostral factor does not bind directly to EGF receptors but inhibits 125I-EGF binding by an indirect mechanism which involves a temperature-sensitive step.

scholarly journals Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site.

1991 ◽  
Vol 266 (29) ◽  
pp. 19139-19141
Author(s):  
H. Arita ◽  
K. Hanasaki ◽  
T. Nakano ◽  
S. Oka ◽  
H. Teraoka ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Binding Site ◽  
Specific Binding ◽  
3T3 Cells ◽  
Proliferative Effect ◽  
Swiss 3T3

scholarly journals Nuclear GTP-binding proteins of Swiss 3T3 cells

FEBS Letters ◽  
1989 ◽  
Vol 244 (2) ◽  
pp. 469-472 ◽  
Author(s):  
Shizu Takeda ◽  
Hiromi Sugiyama ◽  
Shunji Natori ◽  
Kazuhisa Sekimizu
Keyword(s):  
Binding Proteins ◽  
3T3 Cells ◽  
Gtp Binding Proteins ◽  
Gtp Binding ◽  
Swiss 3T3

Mobilization of intracellular calcium by endothelin in Swiss 3T3 cells

1989 ◽  
Vol 161 (2) ◽  
pp. 489-495 ◽  
Author(s):  
Ai Ohnishi ◽  
Ken Yamaguchi ◽  
Masatoshi Kusuhara ◽  
Kaoru Abe ◽  
Satoshi Kimura
Keyword(s):  
Intracellular Calcium ◽  
3T3 Cells ◽  
Swiss 3T3
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