Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b15-00923 ◽

2016 ◽

Vol 39 (4) ◽

pp. 570-577 ◽

Author(s):

Kota Naito ◽

Hajime Moteki ◽

Mitsutoshi Kimura ◽

Hideshi Natsume ◽

Masahiko Ogihara

Keyword(s):

Growth Factor ◽

Dna Synthesis ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

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Serotonin-induced DNA synthesis and proliferation are mediated by autocrine secretion of transforming growth factor-α in primary cultures of adult rat hepatocytes

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.wcp2018.0_po2-6-3 ◽

2018 ◽

Vol WCP2018 (0) ◽

pp. PO2-6-3

Author(s):

Kota Naito ◽

Kazuki Kurihara ◽

Hajime Moteki ◽

Mitsutoshi Kimura ◽

Masahiko Ogihara

Keyword(s):

Growth Factor ◽

Dna Synthesis ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

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Effect of Selective Serotonin (5-HT)2B Receptor Agonist BW723C86 on Epidermal Growth Factor/Transforming Growth Factor-α Receptor Tyrosine Kinase and Ribosomal p70 S6 Kinase Activities in Primary Cultures of Adult Rat Hepatocytes

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b18-00831 ◽

2019 ◽

Vol 42 (4) ◽

pp. 631-637

Author(s):

Kota Naito ◽

Kazuki Kurihara ◽

Hajime Moteki ◽

Mitsutoshi Kimura ◽

Hideshi Natsume ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

S6 Kinase ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

Epidermal Growth ◽

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Signal Transduction Mechanism for 5-HT2B Receptor-Stimulated Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.wcp2018.0_po2-6-11 ◽

2018 ◽

Vol WCP2018 (0) ◽

pp. PO2-6-11

Author(s):

Hajime Moteki ◽

Kota Naito ◽

Kazuki Kurihara ◽

Mitsutoshi Kimura ◽

Masahiko Ogihara

Keyword(s):

Signal Transduction ◽

Growth Factor ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Transforming Growth Factor Α ◽

Transduction Mechanism ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

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Transforming Growth Factor-α Stimulates Proto-Oncogene c-junExpression and a Mitogenic Program in Primary Cultures of Adult Rat Hepatocytes

DNA ◽

10.1089/dna.1.1989.8.279 ◽

1989 ◽

Vol 8 (4) ◽

pp. 279-285 ◽

Author(s):

DAVID A. BRENNER ◽

KATHERINE S. KOCH ◽

HYAM L. LEFFERT

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

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IP Receptor Agonist–Induced DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes: the Involvement of Endogenous Transforming Growth Factor-α

Journal of Pharmacological Sciences ◽

10.1254/jphs.08338fp ◽

2009 ◽

Vol 109 (4) ◽

pp. 618-629 ◽

Author(s):

Mitsutoshi Kimura ◽

Hiroshi Okamoto ◽

Hideshi Natsume ◽

Masahiko Ogihara

Keyword(s):

Growth Factor ◽

Receptor Agonist ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Ip Receptor ◽

Adult Rat Hepatocytes ◽

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Activation of ribosomal p70 S6 kinase by selective serotonin (5-HT)2B receptor agonist BW723C86 is mediated by epidermal growth factor/transforming growth factor-α receptor tyrosine kinase in primary cultures of adult rat hepatocytes.

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.93.0_1-p-101 ◽

2020 ◽

Vol 93 (0) ◽

pp. 1-P-101

Author(s):

Kazuki Kurihara ◽

Hajime Moteki ◽

Masahiko Ogihara ◽

Mitsutoshi Kimura

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

S6 Kinase ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

Epidermal Growth ◽

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Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: The involvement of endogenous transforming growth factor-α

European Journal of Pharmacology ◽

10.1016/j.ejphar.2008.12.004 ◽

2009 ◽

Vol 604 (1-3) ◽

pp. 12-19 ◽

Author(s):

Hiroshi Okamoto ◽

Mitsutoshi Kimura ◽

Noriyuki Watanabe ◽

Masahiko Ogihara

Keyword(s):

Tumor Necrosis ◽

Transforming Growth Factor ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Tnf Receptor ◽

Transforming Growth Factor Α ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

Factor Α ◽

Necrosis Factor

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Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes

European Journal of Pharmacology ◽

10.1016/s0014-2999(98)00455-5 ◽

1998 ◽

Vol 354 (2-3) ◽

pp. 271-281 ◽

Author(s):

Mitsutoshi Kimura ◽

Masahiko Ogihara

Keyword(s):

Growth Factor ◽

Dna Synthesis ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Insulin Like Growth Factor ◽

Adult Rat ◽

Factor I ◽

Adult Rat Hepatocytes ◽

Growth Factor I

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Inhibitory Effects of Dexamethasone on Hepatocyte Growth Factor–Induced DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes

Journal of Pharmacological Sciences ◽

10.1254/jphs.10302fp ◽

2011 ◽

Vol 115 (3) ◽

pp. 390-398 ◽

Author(s):

Mitsutoshi Kimura ◽

Hajime Moteki ◽

Masahiko Ogihara

Keyword(s):

Growth Factor ◽

Hepatocyte Growth Factor ◽

Dna Synthesis ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Inhibitory Effects ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

Hepatocyte Growth

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Effect of calf and rat serum on the induction of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes by cyproterone acetate and epidermal growth factor

In Vitro Cellular & Developmental Biology ◽

10.1007/bf02620920 ◽

1985 ◽

Vol 21 (12) ◽

pp. 665-673 ◽

Author(s):

W. Parzefall ◽

P. R. Galle ◽

R. Schulte-Hermann

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Dna Synthesis ◽

Cyproterone Acetate ◽

Primary Cultures ◽

Rat Hepatocytes ◽

Rat Serum ◽

Adult Rat ◽

Adult Rat Hepatocytes ◽

Epidermal Growth

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