Available Technologies and Commercial Devices to Harvest Energy by Human Trampling in Smart Flooring Systems: A Review

Technological innovation has increased the global demand for electrical power and energy. Accordingly, energy harvesting has become a research area of primary interest for the scientific community and companies because it constitutes a sustainable way to collect energy from various sources. In particular, kinetic energy generated from human walking or vehicle movements on smart energy floors represents a promising research topic. This paper aims to analyze the state-of-art of smart energy harvesting floors to determine the best solution to feed a lighting system and charging columns. In particular, the fundamentals of the main harvesting mechanisms applicable in this field (i.e., piezoelectric, electromagnetic, triboelectric, and relative hybrids) are discussed. Moreover, an overview of scientific works related to energy harvesting floors is presented, focusing on the architectures of the developed tiles, the transduction mechanism, and the output performances. Finally, a survey of the commercial energy harvesting floors proposed by companies and startups is reported. From the carried-out analysis, we concluded that the piezoelectric transduction mechanism represents the optimal solution for designing smart energy floors, given their compactness, high efficiency, and absence of moving parts.

IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases

This study provides evidence supporting the proposal that IP3 signaling in cardiac atria and sinoatrial node involves stimulation of Ca2+-activated adenylyl cyclases (AC1 and AC8) by IP3-evoked Ca2+ release from junctional sarcoplasmic reticulum. AC8 and IP3 receptors are shown to be located close together, while AC1 is nearby. Greater understanding of these novel aspects of the IP3 signal transduction mechanism is important for future study in atrial physiology and pathophysiology, particularly atrial fibrillation.

Predicted structure of fully activated human bitter taste receptor TAS2R4 complexed with G protein and agonists

Bitter taste is sensed by bitter taste receptors (TAS2Rs) that belong to the G protein-coupled receptor (GPCR) superfamily. In addition to bitter taste perception, TAS2Rs have been reported recently to be expressed in many extraoral tissues and are now known to be involved in health and disease. Despite important roles of TAS2Rs in biological functions and diseases, no crystal structure is available to help understand the signal transduction mechanism or to help develop selective ligands as new therapeutic targets. We report here the three-dimensional structure of the fully activated TAS2R4 human bitter taste receptor predicted using the GEnSeMBLE complete sampling method. This TAS2R4 structure is coupled to the gustducin G protein and to each of several agonists. We find that the G protein couples to TAS2R4 by forming strong salt bridges to each of the three intracellular loops, orienting the activated Gα5 helix of the Gα subunit to interact extensively with the cytoplasmic region of the activated receptor. We find that the TAS2Rs exhibit unique motifs distinct from typical Class A GPCRs, leading to a distinct activation mechanism and a less stable inactive state. This fully activated bitter taste receptor complex structure provides insight into the signal transduction mechanism and into ligand binding to TAS2Rs.