scholarly journals The Effective Allergenic Reactivity of House Dust Mite Sublingual Immunotherapy Tablets Is Determined by Tablet Formulation

2019 ◽  
Vol 42 (6) ◽  
pp. 1030-1033 ◽  
Author(s):  
Hirokazu Kito ◽  
Weibin Du ◽  
Hiroshi Nakazawa ◽  
Kaare Lund ◽  
Katsuyo Ohashi-Doi
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Tablet Formulation ◽  
Dust Mite

scholarly journals Effects of sublingual immunotherapy in a murine asthma model sensitized by intranasal administration of house dust mite extracts

2017 ◽  
Vol 66 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Kenjiro Shima ◽  
Toshiyuki Koya ◽  
Keisuke Tsukioka ◽  
Takuro Sakagami ◽  
Takashi Hasegawa ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Intranasal Administration ◽  
Sublingual Immunotherapy ◽  
Asthma Model ◽  
Dust Mite ◽  
Murine Asthma Model

scholarly journals Stability evaluation of house dust mite vaccines for sublingual immunotherapy

2010 ◽  
Vol 75 (1) ◽  
pp. 19-26
Author(s):  
Lidija Burazer ◽  
Katarina Milovanovic ◽  
Tanja Cirkovic-Velickovic ◽  
Marija Gavrovic-Jankulovic
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Protein Profile ◽  
Binding Potential ◽  
Allergen Specific Immunotherapy ◽  
Sds Page ◽  
Dust Mite ◽  
The Stability ◽  
Allergen Extracts

Allergen-specific immunotherapy with house dust mite (HDM) allergen extracts can effectively alleviate the symptoms of allergic rhinitis and asthma. The efficacy of the immunotherapeutic treatment is highly dependent on the quality of house dust mite vaccines. This study was performed to assess the stability of house dust mite allergen vaccines prepared for sublingual immunotherapy. Lyophilized Dermatophagoides pteronyssinus (Dpt) mite bodies were the starting material for the production of sublingual vaccines in four therapeutic concentrations. The stability of the extract for vaccine production, which was stored below 4 ?C for one month, showed consistence in the protein profile in SDS PAGE. ELISA-inhibition showed that the potencies of Dpt vaccines during a 12 month period were to 65-80 % preserved at all analyzed therapeutic concentrations. This study showed that glycerinated Dpt vaccines stored at 4?C preserved their IgE-binding potential during a 12 month period, implying their suitability for sublingual immunotherapeutic treatment of HDM allergy.

scholarly journals Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre‐school children

Allergy ◽  
2019 ◽  
Vol 74 (4) ◽  
pp. 780-787 ◽  
Author(s):  
Marta Ponce ◽  
Fabian Schroeder ◽  
Christina Bannert ◽  
Klara Schmidthaler ◽  
Christian Skjødt Hansen ◽  
...  
Keyword(s):  
School Children ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract

Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber

2015 ◽  
Vol 135 (6) ◽  
pp. 1494-1501.e6 ◽  
Author(s):  
Hendrik Nolte ◽  
Jennifer Maloney ◽  
Harold S. Nelson ◽  
David I. Bernstein ◽  
Susan Lu ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Exposure Chamber ◽  
Dust Mite ◽  
Environmental Exposure Chamber
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