scholarly journals Design and Synthesis of Cinanserin Analogs as Severe Acute Respiratory Syndrome Coronavirus 3CL Protease Inhibitors

2008 ◽  
Vol 56 (10) ◽  
pp. 1400-1405 ◽  
Author(s):  
Qingang Yang ◽  
Lili Chen ◽  
Xuchang He ◽  
Zhenting Gao ◽  
Xu Shen ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitors ◽  
Design And Synthesis ◽  
3Cl Protease

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

2011 ◽  
Vol 39 (5) ◽  
pp. 1371-1375 ◽  
Author(s):  
R. Ramajayam ◽  
Kian-Pin Tan ◽  
Po-Huang Liang
Keyword(s):  
Drug Discovery ◽  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitors ◽  
Therapeutic Agents ◽  
3C Protease ◽  
The World ◽  
Structural Differences ◽  
Life Threatening ◽  
Dual Inhibitors ◽  
3Cl Protease

SARS-CoV (severe acute respiratory syndrome-associated coronavirus) caused infection of ~8000 people and death of ~800 patients around the world during the 2003 outbreak. In addition, picornaviruses such as enterovirus, coxsackievirus and rhinovirus also can cause life-threatening diseases. Replication of picornaviruses and coronaviruses requires 3Cpro (3C protease) and 3CLpro (3C-like protease) respectively, which are structurally analogous with chymotrypsin-fold, but the former is a monomer and the latter is dimeric due to an extra third domain for dimerization. Subtle structural differences in the S2 and S3 pockets of these proteases make inhibitors selective, but some dual inhibitors have been discovered. Our findings as summarized in the present review provide new potential anti-coronavirus and anti-picornavirus therapeutic agents and a clue to convert 3CLpro inhibitors into 3Cpro inhibitors and vice versa.

scholarly journals An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

2016 ◽  
Vol 59 (14) ◽  
pp. 6595-6628 ◽  
Author(s):  
Thanigaimalai Pillaiyar ◽  
Manoj Manickam ◽  
Vigneshwaran Namasivayam ◽  
Yoshio Hayashi ◽  
Sang-Hun Jung
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitors ◽  
Small Molecule ◽  
3Cl Protease

scholarly journals Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors

ChemBioChem ◽  
2007 ◽  
Vol 8 (14) ◽  
pp. 1654-1657 ◽  
Author(s):  
Yi-Ming Shao ◽  
Wen-Bin Yang ◽  
Hung-Pin Peng ◽  
Min-Feng Hsu ◽  
Keng-Chang Tsai ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Design And Synthesis ◽  
3Cl Protease

scholarly journals Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety

2013 ◽  
Vol 21 (2) ◽  
pp. 412-424 ◽  
Author(s):  
Sho Konno ◽  
Pillaiyar Thanigaimalai ◽  
Takehito Yamamoto ◽  
Kiyohiko Nakada ◽  
Rie Kakiuchi ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Design And Synthesis ◽  
3Cl Protease

Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors

2005 ◽  
Vol 48 (22) ◽  
pp. 6767-6771 ◽  
Author(s):  
Arun K. Ghosh ◽  
Kai Xi ◽  
Kiira Ratia ◽  
Bernard D. Santarsiero ◽  
Wentao Fu ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protease Inhibitors ◽  
Design And Synthesis

scholarly journals Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza ‐decaline scaffold

Biopolymers ◽  
2016 ◽  
Vol 106 (4) ◽  
pp. 391-403 ◽  
Author(s):  
Kenta Teruya ◽  
Yasunao Hattori ◽  
Yasuhiro Shimamoto ◽  
Kazuya Kobayashi ◽  
Akira Sanjoh ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Structural Basis ◽  
Peptide Mimic ◽  
3Cl Protease

Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands

2011 ◽  
Vol 21 (12) ◽  
pp. 3730-3733 ◽  
Author(s):  
Bing-Lei Gao ◽  
Cheng-Mei Zhang ◽  
Yi-Zhen Yin ◽  
Long-Qian Tang ◽  
Zhao-Peng Liu
Keyword(s):  
Protease Inhibitors ◽  
Design And Synthesis ◽  
Hiv 1
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