scholarly journals Sex Difference in the Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Pentobarbital-Induced Sleeping Time and Hepatic Microsomal Drug Metabolizing Enzyme Systems in Mice

1983 ◽  
Vol 103 (12) ◽  
pp. 1289-1297 ◽  
Author(s):  
KOICHI HAMAJIMA ◽  
KAZUHITO WATANABE ◽  
SHIZUO NARIMATSU ◽  
YUJI TATEOKA ◽  
IKUO YAMAMOTO ◽  
...  
Keyword(s):  
Sex Difference ◽  
Sleeping Time ◽  
Enzyme Systems ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals Stimulation of Hepatic Microsomal Drug-Metabolizing Enzyme Systems in Primates by DDT

1966 ◽  
Vol 51 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Mont R. Juchau ◽  
Theodore E. Gram ◽  
James R. Fouts
Keyword(s):  
Enzyme Systems ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Stimulation Of

Drug metabolizing enzyme systems in the houbara bustard (Chlamydotis undulata)

1998 ◽  
Vol 120 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Tom A. Bailey ◽  
Annie John ◽  
Eric P. Mensah-Brown ◽  
Andrew Garner ◽  
Jaime Samour ◽  
...  
Keyword(s):  
Enzyme Systems ◽  
Drug Metabolizing Enzyme ◽  
Houbara Bustard ◽  
Metabolizing Enzyme

scholarly journals The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes

1976 ◽  
Vol 154 (3) ◽  
pp. 773-780 ◽  
Author(s):  
F J. McPherson ◽  
J W. Bridges ◽  
D V. Parke
Keyword(s):  
Intraperitoneal Administration ◽  
Albino Rats ◽  
Hydroxylase Activity ◽  
Metabolizing Enzymes ◽  
Enzyme Systems ◽  
Drug Metabolizing Enzyme ◽  
In Vitro Investigation ◽  
Wistar Albino Rats ◽  
Metabolizing Enzyme

A study was made of the nature and specificity of the increase in biphenyl 2-hydroxylase activity after preincubation of liver microsomal preparations with various carcinogens in vitro. This enhancement of enzyme activity in vitro was investigated in mouse, hamster and rat, and although the rat appears to be atypical in the variation of the pattern of 2- and 4-hydroxylation with age, similar enhancements were detectable in each species examined. An increase in biphenyl 2-hydroxylase activity was apparent 2h after intraperitoneal administration of safrole or benzopyrene to mature Wistar albino rats and appeared to be similar in nature to that observed after preincubation of liver microsomal preparations with the same chemical in vitro. Investigation of other drug-metabolizing enzyme systems suggests that the enhancing effects of carcinogens in vitro are specific for biphenyl 2-hydroxylase. No correlation between the enhancement of biphenyl 2-hydroxylase and inhibtion of biphenyl 4-hydroxylase was apparent.

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