Malignant Leydig cell tumour in a Tupaia belangeri: case report and literature review of male genital tumours in non-human primates

After a short summary of the few reported tumours of the male genital system in non-human primates, a malignant Leydig cell tumour is described in an adult male Tupaia belangeri. The tumour had metastasized in the omentum probably by haematogenous spread enabled by the peculiar perivascular growth pattern of the tumour cells. Its differential diagnosis versus seminomas and Sertoli cell tumours is discussed.

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Histopathological Spectrum of Male Genital System Tumours in a Tertiary Care Hospital Faridkot, Punjab

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/49233.15418 ◽

2021 ◽

Author(s):

Aradhana Singh Hada ◽

Sarita Nibhoria ◽

Vaneet Kaur Sandhu ◽

Nitin Nagpal

Keyword(s):

Germ Cell ◽

Genital Tract ◽

Germ Cell Tumour ◽

Cell Tumour ◽

World Health ◽

Categorical Variables ◽

Genital System ◽

Male Genital Tract ◽

Male Genital System ◽

Male Genital

Introduction: The male genital system consists of the prostate, seminal vesicle, testes, epididymis, vas deferens, bulbourethral gland, ejaculatory duct, penis and scrotum. Male genital cancers are histologically diverse. They are difficult to detect and treat because of their anatomic locations, biological characters and complications. Aim: To study the histopathological spectrum of tumours of the male genital system according to World Health Organisation (WHO) classification. Materials and Methods: The present study is a hospital based descriptive study conducted in the Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India, during February 2019 to August 2020 which included 128 cases. All biopsies, specimens and review blocks and slides of male genital tract tumours were processed and slides were stained with Haematoxylin and Eosin (H&E) stain. Serum tumour markers and immunohistochemical stains were used. The clinical information including symptoms related to the male genital system, histopathological findings and diagnosis were recorded on the predesigned proforma. Other necessary information was collected from the requisition form received along with the biopsy material. The association between categorical variables was explored using Pearson’s Chi-square test. A p-value <0.05 was considered statistically significant for this study. Results: The present study included 128 cases, of which the majority of the cases 82 cases (64%) were that of prostate, 28 cases (21.9%) of the penis, 15 cases (11.7%) of testes, two cases (1.6%) were that of the scrotum and one case (0.8%) was of the epididymis. The histopathological spectrum showed adenocarcinoma was present in 80 (62.5%), leiomyosarcoma in 01 (0.8%), lymphoma in 01 (0.8%), mixed germ cell tumour in 9 (7%), seminoma in 5 (3.9%), postpubertal teratoma in 1 (0.8%), basaloid in 1 (0.8%), papillary- basaloid in 2 (1.6%). Conclusion: Prostate tumours outnumbered all other tumours of the male genital tract with adenocarcinoma of prostate followed by squamous cell carcinoma of the penis and mixed Germ Cell Tumour (GCT) of testes. The present study provides updated information regarding the histopathological spectrum of male genital system tumours.

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Ageing, testicular tumours and the pituitary-testis axis in dogs

Journal of Endocrinology ◽

10.1677/joe.0.1660153 ◽

2000 ◽

Vol 166 (1) ◽

pp. 153-161 ◽

Cited By ~ 38

Author(s):

MA Peters ◽

FH de Jong ◽

KJ Teerds ◽

DG de Rooij ◽

SJ Dieleman ◽

...

Keyword(s):

Sertoli Cell ◽

Leydig Cell ◽

Venous Blood ◽

Cell Tumour ◽

Age Related ◽

Sertoli Cell Tumour ◽

Leydig Cell Tumour ◽

Sertoli Cell Tumours ◽

Leydig Cell Tumours ◽

Age Related Changes

Dogs of different ages without testicular diseases were evaluated to study possible age-related changes in hormone concentrations in serum. Dogs with testicular tumours were also investigated to study the relation between tumour type and hormone concentrations; in this study, dogs with Sertoli cell tumours, Leydig cell tumours and seminomas were included. We measured testosterone, oestradiol, LH, FSH and inhibin-like immunoreactivity concentrations in peripheral venous and testicular venous blood of these animals. In normal dogs there appeared to be no age-related changes in the concentrations of the investigated hormones, except for a significant age-related decrease in oestradiol concentrations in testicular venous blood (P<0.02). Dogs with a Sertoli cell tumour had greater oestradiol concentrations and inhibin-like immunoreactivity in both peripheral and testicular venous blood than did dogs without a neoplasm (P<0. 05). Testosterone concentrations were reduced in dogs with Sertoli cell tumours, as were FSH and LH. Feminisation occurred in eight of 13 dogs with a Sertoli cell tumour and in two of 14 dogs with a Leydig cell tumour; it was accompanied by a significantly greater oestradiol concentration than in normal dogs and in dogs with Sertoli cell tumours without signs of feminisation. Dogs with a Leydig cell tumour had greater concentrations of oestradiol and inhibin-like immunoreactivity in both peripheral venous and testicular venous blood than did dogs without a neoplasm (P<0.05). The testosterone concentration in testicular venous blood of these dogs was lower than that in dogs with normal testes. The concentration of LH in peripheral venous blood was also reduced (P<0. 05). Hormone concentrations in dogs with a seminoma were not different from those in normal dogs. It was concluded that seminomas are not endocrinologically active. In contrast, both Sertoli cell tumours and Leydig cell tumours can cause increased oestrogen production leading to signs of feminisation. These tumours also have considerable amounts of inhibin-like immunoreactivity, but only in Sertoli cell tumours does this result in a reduction in FSH concentrations, suggesting that Sertoli cell tumours secrete dimeric inhibin, whereas Leydig cell tumours presumably produce loose alpha-subunits that cross-react in the inhibin assay but are not biologically active.

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Morphologic differences between abdominal and inguinal testes in stallions

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100128389 ◽

1987 ◽

Vol 45 ◽

pp. 820-821

Author(s):

F. Al-Bagdadi ◽

D. Hoyt ◽

P. Karns ◽

G. Martin ◽

M. Memon ◽

...

Keyword(s):

Carcinoma Cells ◽

Genital System ◽

Diagnosis And Prognosis ◽

Male Genital System ◽

Morphological Differences ◽

Hormone Imbalance ◽

Made In ◽

Male Genital

The most frequently occuring abnormality of the male genital system in mammals is the failure of one or both testes to descend into the scrotum. The reasons for abdominal or inguinal retention of testes could be anatomic malformation, faulty development or hormone imbalance.Cryptorchidism has been associated with either greatly reduced or absent spermatogenesis (Kaueakami et al, 1984), and being a source of neoplasia. According to Stick (1980), germinal carcinoma cells have been believed to be the cause of teratomas in equine cryptorchid testicles. Neoplasia has been reported in descended testes of unilateral cryptorchid patients (Martin et al, 1981).No distinction has been made in relating the problem of cryptorchid testes to inguinal or abdominal retention. The purpose of this study is to record the morphological differences between inguinal and abdominal cryptorchid testes as an aid in diagnosis and prognosis.

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NEW VIEWS ON THE HORMONE-PRODUCING MESENCHYMOMAS OF THE OVARIES

Acta Endocrinologica ◽

10.1530/acta.0.xxxv0513 ◽

1960 ◽

Vol XXXV (IV) ◽

pp. 513-517

Author(s):

W. P. Plate

Keyword(s):

Granulosa Cell ◽

Sertoli Cell ◽

Leydig Cell ◽

Cell Tumour ◽

Theca Cell ◽

Granulosa Cell Tumour ◽

Sertoli Cell Tumours ◽

Leydig Cell Tumours

ABSTRACT The hormone-producing mesenchymomas of the ovaries can be divided into androblastomas and gynaecoblastomas. The former are derived from »male« elements, and consist of Sertoli-cell tumours and Leydig-cell tumours. The latter arise from »female« elements and consist of granulosacell tumours and theca-cell tumours. Sertoli-cell tumours and granulosacell tumours produce oestrogens, while Leydig-cell tumours and theca-cell tumours produce oestrogens or androgens. Histologically, androblastomas and gynaecoblastomas are often difficult to distinguish. Since no »female« elements occur in a testicle, a granulosa-cell tumour in a testicle is improbable. Gynandroblastomas, therefore, can only be found in an ovary.

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