Histopathological Spectrum of Male Genital System Tumours in a Tertiary Care Hospital Faridkot, Punjab

Introduction: The male genital system consists of the prostate, seminal vesicle, testes, epididymis, vas deferens, bulbourethral gland, ejaculatory duct, penis and scrotum. Male genital cancers are histologically diverse. They are difficult to detect and treat because of their anatomic locations, biological characters and complications. Aim: To study the histopathological spectrum of tumours of the male genital system according to World Health Organisation (WHO) classification. Materials and Methods: The present study is a hospital based descriptive study conducted in the Department of Pathology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India, during February 2019 to August 2020 which included 128 cases. All biopsies, specimens and review blocks and slides of male genital tract tumours were processed and slides were stained with Haematoxylin and Eosin (H&E) stain. Serum tumour markers and immunohistochemical stains were used. The clinical information including symptoms related to the male genital system, histopathological findings and diagnosis were recorded on the predesigned proforma. Other necessary information was collected from the requisition form received along with the biopsy material. The association between categorical variables was explored using Pearson’s Chi-square test. A p-value <0.05 was considered statistically significant for this study. Results: The present study included 128 cases, of which the majority of the cases 82 cases (64%) were that of prostate, 28 cases (21.9%) of the penis, 15 cases (11.7%) of testes, two cases (1.6%) were that of the scrotum and one case (0.8%) was of the epididymis. The histopathological spectrum showed adenocarcinoma was present in 80 (62.5%), leiomyosarcoma in 01 (0.8%), lymphoma in 01 (0.8%), mixed germ cell tumour in 9 (7%), seminoma in 5 (3.9%), postpubertal teratoma in 1 (0.8%), basaloid in 1 (0.8%), papillary- basaloid in 2 (1.6%). Conclusion: Prostate tumours outnumbered all other tumours of the male genital tract with adenocarcinoma of prostate followed by squamous cell carcinoma of the penis and mixed Germ Cell Tumour (GCT) of testes. The present study provides updated information regarding the histopathological spectrum of male genital system tumours.

Download Full-text

Circumcision as an Intervening Strategy against HIV Acquisition in the Male Genital Tract

Pathogens ◽

10.3390/pathogens10070806 ◽

2021 ◽

Vol 10 (7) ◽

pp. 806

Author(s):

Adhikarimayum Lakhikumar Sharma ◽

Joseph Hokello ◽

Mudit Tyagi

Keyword(s):

Hiv Infection ◽

Genital Tract ◽

Hiv Transmission ◽

International Health ◽

Public Understanding ◽

World Health ◽

Unsafe Sex ◽

Male Genital Tract ◽

Hiv Acquisition ◽

Male Genital

Unsafe sex with HIV-infected individuals remains a major route for HIV transmission, and protective strategies, such as the distribution of free condoms and pre-or post-prophylaxis medication, have failed to control the spread of HIV, particularly in resource-limited settings and high HIV prevalence areas. An additional key strategy for HIV prevention is voluntary male circumcision (MC). International health organizations (e.g., the World Health Organization, UNAIDS) have recommended this strategy on a larger scale, however, there is a general lack of public understanding about how MC effectively protects against HIV infection. This review aims to discuss the acquisition of HIV through the male genital tract and explain how and why circumcised men are more protected from HIV infection during sexual activity than uncircumcised men who are at higher risk of HIV acquisition.

Download Full-text

Malignant Leydig cell tumour in a Tupaia belangeri: case report and literature review of male genital tumours in non-human primates

Laboratory Animals ◽

10.1258/002367788780864484 ◽

1988 ◽

Vol 22 (2) ◽

pp. 131-134 ◽

Cited By ~ 12

Author(s):

M. Brack

Keyword(s):

Leydig Cell ◽

Cell Tumour ◽

Genital System ◽

Tupaia Belangeri ◽

Short Summary ◽

Male Genital System ◽

Leydig Cell Tumour ◽

Haematogenous Spread ◽

Sertoli Cell Tumours ◽

Male Genital

After a short summary of the few reported tumours of the male genital system in non-human primates, a malignant Leydig cell tumour is described in an adult male Tupaia belangeri. The tumour had metastasized in the omentum probably by haematogenous spread enabled by the peculiar perivascular growth pattern of the tumour cells. Its differential diagnosis versus seminomas and Sertoli cell tumours is discussed.

Download Full-text

Morphologic differences between abdominal and inguinal testes in stallions

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100128389 ◽

1987 ◽

Vol 45 ◽

pp. 820-821

Author(s):

F. Al-Bagdadi ◽

D. Hoyt ◽

P. Karns ◽

G. Martin ◽

M. Memon ◽

...

Keyword(s):

Carcinoma Cells ◽

Genital System ◽

Diagnosis And Prognosis ◽

Male Genital System ◽

Morphological Differences ◽

Hormone Imbalance ◽

Made In ◽

Male Genital

The most frequently occuring abnormality of the male genital system in mammals is the failure of one or both testes to descend into the scrotum. The reasons for abdominal or inguinal retention of testes could be anatomic malformation, faulty development or hormone imbalance.Cryptorchidism has been associated with either greatly reduced or absent spermatogenesis (Kaueakami et al, 1984), and being a source of neoplasia. According to Stick (1980), germinal carcinoma cells have been believed to be the cause of teratomas in equine cryptorchid testicles. Neoplasia has been reported in descended testes of unilateral cryptorchid patients (Martin et al, 1981).No distinction has been made in relating the problem of cryptorchid testes to inguinal or abdominal retention. The purpose of this study is to record the morphological differences between inguinal and abdominal cryptorchid testes as an aid in diagnosis and prognosis.

Download Full-text

A suprasellar germ cell tumour presenting with cranial diabetes insipidus

Endocrine Abstracts ◽

10.1530/endoabs.65.p321 ◽

2019 ◽

Author(s):

Suhaniya Samarasinghe ◽

Rebecca Scott ◽

Michael J Seckl ◽

Mike Gonzalez ◽

Richard Harvey ◽

...

Keyword(s):

Germ Cell ◽

Diabetes Insipidus ◽

Germ Cell Tumour ◽

Cell Tumour ◽

Cranial Diabetes Insipidus

Download Full-text

Cystic trophoblastic tumour: a rare presentation in the mediastinum in a post-chemotherapy patient with previous germ cell tumour in the testis

10.26226/morressier.5b4709866f4cb30010952142 ◽

2018 ◽

Author(s):

Foteini Malta

Keyword(s):

Germ Cell ◽

Germ Cell Tumour ◽

Cell Tumour ◽

Rare Presentation

Download Full-text

Cardiac metastasis of a rapid-moving mixed germ cell tumour visualized by transoesophageal echocardiography

European Heart Journal - Case Reports ◽

10.1093/ehjcr/ytab007 ◽

2021 ◽

Vol 5 (2) ◽

Author(s):

Toshimitsu Kato ◽

Noriaki Takama ◽

Tomonari Harada ◽

Tomonobu Abe

Keyword(s):

Germ Cell ◽

Germ Cell Tumour ◽

Transoesophageal Echocardiography ◽

Cell Tumour ◽

Cardiac Metastasis

Download Full-text

COVD-01. VINBLASTINE MONOTHERAPY INDUCTION FOR LOCALISED CNS GERMINOMA DURING THE COVID-19 PANDEMIC

Neuro-Oncology ◽

10.1093/neuonc/noaa222.032 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii282-iii282

Author(s):

Rafael Moleron ◽

Sara Stoneham ◽

Thankamma Ajithkumar ◽

Justin Cross ◽

James Nicholson ◽

...

Keyword(s):

Germ Cell ◽

Treatment Options ◽

Single Agent ◽

Germ Cell Tumour ◽

Research Priorities ◽

Tumour Volume ◽

Cell Tumour ◽

Low Grade ◽

Testicular Seminoma

Abstract INTRODUCTION Patients with localised CNS-germinoma have excellent survival. More recently, intensive inpatient chemotherapy (carboPEI=carboplatin/etoposide/ifosfamide in Europe) has been effectively employed to reduce radiotherapy fields and/or dose. Current research priorities focus on reducing treatment burden and long-term sequelae. Of note, outpatient-based single-agent carboplatin chemotherapy is associated with excellent outcomes in metastatic testicular seminoma (an identical pathology) [Alifrangis,EJC,2020]. Recently, successful vinblastine monotherapy was reported in localised CNS-germinoma [Murray,Neurooncol-Adv,2020]. METHODS Due to the COVID-19 pandemic, adapted UK guidelines for germ-cell-tumour management were distributed, including potential non-standard treatment options that would reduce hospital visits/admissions. A 30-year-old patient presented with a 32mmx30mmx35mm diameter solid+multi-cystic localised pineal CNS lesion, consistent radiologically with a germ-cell-tumour with prominent teratoma component. Investigation revealed negative AFP/HCG markers and biopsy-proven pure germinoma. After appropriate consent, the patient commenced 12-week induction with weekly vinblastine monotherapy (low-grade-glioma dosing [Lassaletta,JCO,2016]), with wk6&12 MRI re-assessment prior to definitive radiotherapy. RESULTS Vinblastine was well-tolerated. After initial 4mg/m2 test-dosing (wk1), standard 6mg/m2 was delivered for wk2, but resulted in asymptomatic neutropenia (nadir 0.3x10^9/l) and missed dosing at wk3. Subsequent doses were 4mg/m2, with no further neutropenia. As expected, MRI showed moderate 40% tumour volume reduction by wk12. Surgical resection of the residual presumed teratoma component was undertaken prior to radiotherapy. CONCLUSION Patients with CNS-germinoma have excellent outcomes and reduction of treatment-effects remains a priority. The exquisite chemosensitivity of germinoma, excellent results from monotherapy for metastatic testicular disease, and early promise of vinblastine monotherapy lend itself to further exploration for CNS-germinoma.

Download Full-text