Primary female genital system lymphoma complicated by a recurrent mucinous borderline ovarian tumor: a case report and review of the literature

Background Primary female genital system lymphoma (PFGSL) is an infrequent entity. All genital organs may be affected, and most PFGSLs are localized to the cervix, uterine body, and ovaries. The clinical manifestations are nonspecific, which complicates a timely diagnosis. We report an unexpected case of PFGSL and discuss the disease characteristics by reviewing the literature. Case presentation A 48-year-old G3/P2 woman presented to the Department of Gynecology with a physical examination. Ultrasound examination and CT revealed pelvic masses. The woman underwent surgical treatment because of the pelvic masses and underwent a hysterectomy for a recurrent mucinous borderline ovarian tumor. However, the results of the postoperative pathological examination showed diffuse large B-cell lymphoma of the endometrium. After four courses of chemotherapy, the woman was in good condition. The clinical manifestations were nonspecific, which made a timely diagnosis complex. Conclusion This case highlights the importance of the difficulty in detecting early PFGSL early and how easily nonspecific manifestations can be ignored. It may lead to missing the best time for early treatment.

Five new and five known species of the genus Tylencholaimus de Man, 1876 (Nematoda: Dorylaimida: Tylencholaimoidea) from Western Ghats of India

Five new and five known species of the genus Tylencholaimus de Man, 1876 are described from the Western Ghats of India. Tylencholaimus macroamphidius sp. nov. has a 0.61–0.85 mm long body, angular lips, large amphid, 8.0–9.0 μm long odontostyle, odontophore with asymmetrical basal knobs, pharyngeal bulb expanding gradually, female genital system mono-prodelphic, and a rounded to conoid tail. Tylencholaimus shamimi sp. nov. has a 0.57–0.71 mm long body, 6.0–7.0 μm long odontostyle, odontophore with basal thickening, pharyngeal bulb expanding gradually, female genital system amphidelphic and a convex-conoid tail. Tylencholaimus southindicus sp. nov. has a 0.44–0.55 mm long body, lip region with distinct labial disc, 4.5–5.5 μm long odontostyle, odontophore with minute basal knobs, pharyngeal expansion abrupt, female genital system mono-prodelphic, and a rounded-conoid to rounded tail. Tylencholaimus striatus sp. nov. has a 0.30–0.34 mm long body with distinctly striated cuticle, 5.0–5.5 μm long odontostyle, odontophore with minute basal knobs, pharyngeal bulb expanding abruptly, female genital system mono-prodelphic, and a conoid tail with bluntly rounded terminus. Tylencholaimus tamiliensis sp. nov. has 0.51–0.58 mm long body, 5.5–6.0 μm long odontostyle, odontophore with minute basal knobs, pharyngeal bulb expanding gradually, female genital system mono-prodelphic and tail rounded to conoid with sunken terminus. Five known species of the genus Tylencholaimus viz. T. mirabilis, T. teres, T. micronanus, T. ibericus and T. cosmos also recorded from the region and redescribed/illustrated.

Features of the management of girls with anomalies of the genitourinary system

Aim. To study the clinical and anamnestic, and surgical features of patients with genitourinary system malformations. Materials and methods. A retrospective analysis of data from 252 medical records of patients with genitourinary system malformations who were admitted for examination and treatment to the Department of Pediatric and Adolescent Gynecology of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation from 2012 to 2019. During analysis, special attention was paid to the data of surgical treatment, clinical and anamnestic data and the intraoperative picture. Results. Developmental anomalies of the genital system are combined with urinary system malformations in 21.1% of cases. Genital malformations in adolescent girls are characterized by a high rate of various complications: hematocolpos (53.6), hematocervix (30%), hematometra (26.2%), hematosalpinx (15.1%), endometriosis (19.2%), masses (16.4%) and adhesions (25.4%). Conclusion. Genital system malformations are often associated with anomalies of the urinary system and are characterized by a high risk of complications, therefore, timely identification and multidisciplinary management of such patients from an early age is extremely important.

Im bann der Würgerin – Kamadme, Lamaštu und Lilith in der Hellas?

The following paper explores some possible connections between Greek and Mesopotamian child-killing demons. First, the main Sumerian/Akkadian demoness Kamadme Lamaštu is being characterized and set in comparison with the lil-demons and their singularisation Lilith. Briefly, their modus operandi is being studied with a focus on strangulation. It is being proposed that the reoccurring meme of children being strangled by these demons comes from a misinterpretation of the anatomy of the human body which manifested in the belief in a rāṭu in Mesopotamia or ὁδός in Greece. This organ was believed to be a “channel” that connects women’s genital system with the respiratory tract. With that in mind, some Greek and Roman demons are being considered as potentially being derived from the aforementioned ancient Near Eastern supernatural beings. Hence, the proposal is put forward that the Greek Hesperides, the Theban Sphinx, the Lesbian Gello as well as the Greco-Roman Stri(n)x have in fact been adopted by the Occident from the East.

Identifying the deceiver: the non-neoplastic mimickers of genital system neoplasms

Tumors of the genital system are common and imaging is of crucial importance for their detection and diagnosis. Several non-neoplastic diseases may mimic these tumors and differential diagnosis may be difficult in certain cases. Misdiagnosing non-neoplastic diseases as tumor may prompt unnecessary medical treatment or surgical interventions. In this article, we aimed to present the imaging characteristics of non-neoplastic diseases of the male and female genital systems that may mimic neoplastic processes. Increasing awareness of the imaging specialists to these entities may have a severe positive impact on the management of these patients.

Urogenital System for Women

Functionally, the urogenital system can be divided into two completely different components : urinary system and genital system. However, embryologically and anatomically, the two are closely related. Both originate from a single mesodermal ridge (intermediate mesoderm) along the posterior wall of the abdominal cavity, and initially, the excretory ducts of both systems enter the same cavity, the cloaca. The urogenital system is a system consisting of the urinary system which is divided into the urinary tract and the genital system. Where the urinary system is divided into the upper and lower urinary tracts. The upper urinary tract consists of the kidneys, renal pelvis and ureters, while the lower urinary tract consists of the urinary bladder and urethra. The external genital system in men and women is different, in men it consists of the penis, testes and scrotum, while in women it consists of the vagina, uterus and ovaries. The following will describe the urogenital system in women

PROBLEMATIC ISSUES IN THE ETIOLOGY AND PATHOGENESIS OF ADENOMYOSIS

Nowadays, adenomyosis represents one of the most common pathology of female genital system. It occurs at different ages, including nulliparous, infertile and multiparous women. The etiology of adenomyosis is still under investigation. Despite the fact that there are many different theories, none of them fully explain the mechanisms of adenomyoisis development. The pathogeneis of adenomyosis is also less studied. Many studies indicate the involvement of female sex hormone receptors, cell proliferation and apoptosis, as well as the involvement of inflammation. Some investigators describe the malignant transformation of adenomyosis, which makes the study of the disease etiology and pathogenesis more important. In current review, we discuss the different theories of adenomyosis development, as well as the risk of malignant transformation.

Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors

Epigenetic alterations, particularly RNA methylation, play a crucial role in many types of disease development and progression. Among them, N6-methyladenosine (m6A) is the most common epigenetic RNA modification, and its important roles are not only related to the occurrence, progression, and aggressiveness of tumors but also affect the progression of many non-tumor diseases. The biological effects of RNA m6A modification are dynamically and reversibly regulated by methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). This review summarized the current finding of the RNA m6A modification regulators in male infertility and genital system tumors and discussed the role and potential clinical application of the RNA m6A modification in spermatogenesis and male genital system tumors.