Measurement of blood pressure and heart rate by telemetry in conscious unrestrained marmosets

1995 ◽  
Vol 29 (3) ◽  
pp. 258-261 ◽  
Author(s):  
Christian R. Schnell ◽  
Jeanette M. Wood

A system is described for the continuous measurement of blood pressure, heart rate and motor activity by telemetry in conscious marmosets freely moving in their home cages. Consistent diurnal variations in these parameters were observed under standard conditions. However these parameters were sensitive to changes in the environment. Blood pressure values were similar to those measured by non-telemetric methods in conscious restrained marmosets while heart rate values were significantly lower.

1982 ◽  
Vol 32 ◽  
pp. 268
Author(s):  
Shizuo Nakamura ◽  
Hisashi Ohta ◽  
Shigenori Watanabe ◽  
Showa Ueki

1987 ◽  
Vol 253 (5) ◽  
pp. F952-F958 ◽  
Author(s):  
J. Filep ◽  
J. C. Frolich ◽  
E. Foldes-Filep

To investigate the role of arginine vasopressin (AVP) in the maintenance of blood pressure in deoxycorticosterone (DOC)-salt hypertension, the effects of specific pressor and antidiuretic antagonists of AVP were studied in conscious, freely moving rats with established malignant DOC-salt hypertension. Plasma AVP level was significantly higher in hypertensive than in normotensive animals (4.8 +/- 1.0 vs. 2.0 +/- 0.3 fmol/ml, n = 5, P less than 0.02). Administration of d(CH2)5-d-Leu-VAVP, 10 micrograms/kg, an AVP antagonist that blocked the antidiuretic, but not the pressor effect of exogenous AVP, induced diuresis, and caused a transient fall in blood pressure from 173 +/- 3 to 167 +/- 4 mmHg (n = 8, P less than 0.01) with a concomitant slight increase in heart rate. Similar changes were observed after administration of d(CH2)5Tyr(Et)VAVP, 10 micrograms/kg, an antidiuretic plus pressor antagonist of AVP. Intravenous injection of d(CH2)5Tyr(Me)AVP, 10 micrograms/kg, a specific AVP pressor antagonist had no effect on blood pressure or heart rate, although it completely abolished the pressor response to exogenous AVP. Plasma renin activity remained suppressed following administration of all AVP antagonists. These findings suggest that if AVP should contribute to maintaining high blood pressure in malignant DOC-salt hypertension it would have to be the results of its antidiuretic and not its vasoconstrictor property.


2011 ◽  
Vol 45 (1) ◽  
pp. 50-54 ◽  
Author(s):  
Khalil N Abi-Nader ◽  
Vedanta Mehta ◽  
S W Steven Shaw ◽  
Tom Bellamy ◽  
Neil Smith ◽  
...  

2001 ◽  
Vol 38 (3) ◽  
pp. 490-499 ◽  
Author(s):  
Maarten Buuse ◽  
Saskia A.B.E. Acker ◽  
Marc Fluttert ◽  
E. Ronald Kloet

1987 ◽  
Vol 72 (6) ◽  
pp. 743-748 ◽  
Author(s):  
I. W. Fellows ◽  
D. F. Evans ◽  
T. Bennett ◽  
I. A. Macdonald ◽  
A. G. Clark ◽  
...  

1. The effect of insulin-induced hypoglycaemia on gastro-jejunal motility was studied in five, healthy, male subjects using tethered, pressure sensitive, radiotelemetry capsules. 2. Thirty minutes after the intravenous injection of soluble insulin (0.15 unit/kg body weight), a significant reduction in blood glucose concentration (control: 5.26 ± 0.19 sem mmol/l; insulin: 1.48 ± 0.44 mmol/l; P < 0.001) was associated with a rise in heart rate (mean peak rise 29 ± 8 beats/min, P < 0.05), systolic arterial blood pressure (mean peak rise 28 ± 4 mmHg, P < 0.01) and plasma pancreatic polypeptide concentration (control: 20 ± 7 pmol/l; insulin: 287 ± 66 pmol/l; P < 0.01). These events coincided with a short period of jejunal motor activity, which was not associated with gastric motor activity nor with raised plasma motilin concentrations. 3. During the control study, there were no changes in blood glucose concentration, heart rate, arterial blood pressure or plasma pancreatic polypeptide concentrations, and there was no jejunal motor activity. 4. The interval between successive gastric migrating motor complexes (MMC) was not significantly different in the insulin and control studies (control: median interval 110 min, range 108–148 min; insulin: median interval 124 min, range 115–125 min), suggesting that the fasting gastro-jejunal MMC and jejunal motor activity arose independently. 5. Insulin-induced hypoglycaemia is accompanied by jejunal motor activity, which may underlie the abdominal symptoms associated with hypoglycaemia.


1994 ◽  
Vol 87 (s31) ◽  
pp. 7P-7P
Author(s):  
Gwk Ching ◽  
J Daykin ◽  
JA Franklyin ◽  
MD Gammage

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