scholarly journals Localization of Cathepsins B and D in the Synovial Lining Cells of the Normal Rat Temporomandibular Joint by Immuno-light and -electron Microscopy.

1994 ◽  
Vol 27 (5) ◽  
pp. 441-450 ◽  
Author(s):  
TAMOTSU KIYOSHIMA ◽  
MIZUHO A. KIDO ◽  
TAKAYUKI TSUKUBA ◽  
HIDETAKA SAKAI ◽  
KENJI YAMAMOTO ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Temporomandibular Joint ◽  
Light And Electron Microscopy ◽  
Synovial Lining ◽  
Synovial Lining Cells ◽  
Normal Rat

Immunocytochemical localization of cathepsin L in the synovial lining cells of the rat temporomandibular joint

1994 ◽  
Vol 39 (12) ◽  
pp. 1049-1056 ◽  
Author(s):  
T. Kiyoshima ◽  
M.A. Kido ◽  
Y. Nishimura ◽  
M. Himeno ◽  
T. Tsukuba ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Cathepsin L ◽  
Immunocytochemical Localization ◽  
Synovial Lining ◽  
Synovial Lining Cells

The Third Dimension of Rheumatoid Arthritis

1970 ◽  
Vol 28 ◽  
pp. 338-339
Author(s):  
Jeanne M. Riddle ◽  
Gilbert B. Bluhm
Keyword(s):  
Rheumatoid Arthritis ◽  
Electron Microscopy ◽  
Membrane Surface ◽  
Three Dimensional ◽  
Joint Space ◽  
Cell Contact ◽  
Synovial Lining ◽  
Synovial Lining Cells ◽  
Third Dimension ◽  
Dynamic Quality

Our application of scanning electron microscopy to the investigation of synovial membrane surface topography in humans has yielded new morphologic information. Samples of synovium removed from patients with advanced rheumatoid arthritis exhibited projecting villi such as those depicted in Fig. 1 as a prominent feature of their three-dimensional microarchi-tecture. In addition, localized areas of fibrin deposition, large parallel folds and focal irregular cavities were observed. Synovial lining cells were protuberant, increased in number and variable in size with many larger synoviocytes evident. Individual synoviocytes or small clusters were separated by only narrow areas of intercellular matrix. Membrane activities such as erythrophagocytosis and pinocytosis, the latter illustrated in Fig. 2, attested to the dynamic quality of the synovial lining cells as they participated in this inflammatory disease state. Frequently individual synovial lining cells were connected by slender, intercellular cytoplasmic spans. This form of cellular linkage illustrated in Fig. 2-was heretofore undiscovered by studies utilizing either light or transmission electron microscopy. Large finger-like structures depicted in Fig. 2 also jutted from some synoviocytes and either extended into the joint space or bridged gaps between adjacent synovial lining cells. In the latter situation, these filopodia perhaps served as a second type of adhesive cell contact as the layers of synoviocytes increased in depth.

scholarly journals Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint

2015 ◽  
Vol 228 (3) ◽  
pp. 520-529 ◽  
Author(s):  
Kayoko Nozawa-Inoue ◽  
Fumiko Harada ◽  
Jin Magara ◽  
Atsushi Ohazama ◽  
Takeyasu Maeda
Keyword(s):  
Temporomandibular Joint ◽  
Synovial Lining ◽  
Synovial Lining Cells

Brain damage from 125I brachytherapy evaluated by MR imaging, a blood-brain barrier tracer, and light and electron microscopy in a rat model

1990 ◽  
Vol 73 (4) ◽  
pp. 585-593 ◽  
Author(s):  
Mark Bernstein ◽  
Tom Marotta ◽  
Patricia Stewart ◽  
Jennifer Glen ◽  
Lothar Resch ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Mr Imaging ◽  
Blood Brain Barrier ◽  
Light And Electron Microscopy ◽  
Brain Barrier ◽  
Content Type ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Normal Rat ◽  
Brain Barrier Disruption

✓ Changes in normal rat brain were studied acutely, and at 3, 6, 9, and 12 months following interstitial brachytherapy with high-activity 125I seeds. An 80-Gy radiation dose was administered to an area with a 5.5-mm radius. Effects were measured with magnetic resonance (MR) imaging (with and without gadolinium enhancement), leakage of horseradish peroxidase(HRP), electron microscopy, and light microscopy. Significant histological damage was seen at radiation doses above 295 Gy, and breakdown of the blood-brain barrier was observed only in tissue receiving a dose of 165 Gy or greater. Blood-brain barrier breakdown increased up to the 6-month time point, and thereafter appeared to stabilize or decrease. The area of blood-brain barrier disruption indicated by gadolinium-enhanced MR imaging was greater than that indicated by leakage of HRP.

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