scholarly journals Research Progress of PiCCO on EGDT in Patients with Septic Shock

2018 ◽  
Vol 08 (03) ◽  
pp. 275-280
Author(s):  
振菁 刘
2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Xin Yan

Atropine (atropinol) is a typical anticholinergic drug that competes for M receptors. Large doses of atropine can expand blood vessels, relieve small vasospasm, improve microcirculation as well as cardiovascular function, and inhibit thromboxane formation. It is an ideal drug for the treatment of septic shock that are worthy of clinical application. In recent years, studies have found that the main mechanisms of atropine's anti-infective shock include inhibiting calcium ion overload, improving microcirculation disorders, inhibiting thromboxane formation, reducing the release of inflammatory mediators, and inhibiting the release of glutamate. The research progress of the pharmacological effects and mechanisms of atropine in the treatment of septic shock is summarized, and it provides a basis for the in-depth study of atropine.


2019 ◽  
Vol 227 (1) ◽  
pp. 64-82 ◽  
Author(s):  
Martin Voracek ◽  
Michael Kossmeier ◽  
Ulrich S. Tran

Abstract. Which data to analyze, and how, are fundamental questions of all empirical research. As there are always numerous flexibilities in data-analytic decisions (a “garden of forking paths”), this poses perennial problems to all empirical research. Specification-curve analysis and multiverse analysis have recently been proposed as solutions to these issues. Building on the structural analogies between primary data analysis and meta-analysis, we transform and adapt these approaches to the meta-analytic level, in tandem with combinatorial meta-analysis. We explain the rationale of this idea, suggest descriptive and inferential statistical procedures, as well as graphical displays, provide code for meta-analytic practitioners to generate and use these, and present a fully worked real example from digit ratio (2D:4D) research, totaling 1,592 meta-analytic specifications. Specification-curve and multiverse meta-analysis holds promise to resolve conflicting meta-analyses, contested evidence, controversial empirical literatures, and polarized research, and to mitigate the associated detrimental effects of these phenomena on research progress.


2002 ◽  
Author(s):  
Raymond A. Levy ◽  
Stuart Ablon
Keyword(s):  

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