scholarly journals Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: From systematic review to living systematic review

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 196 ◽  
Author(s):  
Michel Jacques Counotte ◽  
Dianne Egli-Gany ◽  
Maurane Riesen ◽  
Million Abraha ◽  
Teegwendé Valérie Porgo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Zika Virus ◽  
Congenital Abnormalities ◽  
Causal Link ◽  
The Body ◽  
Guillain Barre Syndrome ◽  
Sufficient Evidence ◽  
Zikv Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Background. The Zika virus (ZIKV) outbreak in the Americas has caused international concern due to neurological sequelae linked to the infection, such as microcephaly and Guillain-Barré syndrome (GBS). The World Health Organization stated that there is “sufficient evidence to conclude that Zika virus is a cause of congenital abnormalities and is a trigger of GBS”. This conclusion was based on a systematic review of the evidence published until 30.05.2016. Since then, the body of evidence has grown substantially, leading to this update of that systematic review with new evidence published from 30.05.2016 – 18.01.2017, update 1. Methods. We review evidence on the causal link between ZIKV infection and adverse congenital outcomes and the causal link between ZIKV infection and GBS or immune-mediated thrombocytopaenia purpura. We also describe the transition of the review into a living systematic review, a review that is continually updated. Results. Between 30.05.2016 and 18.01.2017, we identified 2413 publications, of which 101 publications were included. The evidence added in this update confirms the conclusion of a causal association between ZIKV and adverse congenital outcomes. New findings expand the evidence base in the dimensions of biological plausibility, strength of association, animal experiments and specificity. For GBS, the body of evidence has grown during the search period for update 1, but only for dimensions that were already populated in the previous version. There is still a limited understanding of the biological pathways that potentially cause the occurrence of autoimmune disease following ZIKV infection. Conclusions. This systematic review confirms previous conclusions that ZIKV is a cause of congenital abnormalities, including microcephaly, and is a trigger of GBS. The transition to living systematic review techniques and methodology provides a proof of concept for the use of these methods to synthesise evidence about an emerging pathogen such as ZIKV.

scholarly journals Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review

PLoS Medicine ◽  
2017 ◽  
Vol 14 (1) ◽  
pp. e1002203 ◽  
Author(s):  
Fabienne Krauer ◽  
Maurane Riesen ◽  
Ludovic Reveiz ◽  
Olufemi T. Oladapo ◽  
Ruth Martínez-Vega ◽  
...  
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Zika Virus ◽  
Guillain Barre Syndrome ◽  
Brain Abnormalities ◽  
Zika Virus Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype

2020 ◽  
Vol 14 (4) ◽  
pp. e0008264 ◽  
Author(s):  
Sonja E. Leonhard ◽  
Cristiane C. Bresani-Salvi ◽  
Joanna D. Lyra Batista ◽  
Sergio Cunha ◽  
Bart C. Jacobs ◽  
...  
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Zika Virus ◽  
Meta Analysis ◽  
Guillain Barre Syndrome ◽  
Zika Virus Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Zika Virus Infection in the Elderly: Possible Relationship with Guillain-Barré Syndrome

Gerontology ◽  
2016 ◽  
Vol 63 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Wilson Savino ◽  
Carolina V. Messias ◽  
Daniella A. Mendes-da-Cruz ◽  
Pamela Passos ◽  
Ana Carolina A.F. Ferreira ◽  
...  
Keyword(s):  
Zika Virus ◽  
Severe Disease ◽  
The Elderly ◽  
French Polynesia ◽  
Therapeutic Interventions ◽  
Guillain Barre Syndrome ◽  
Zikv Infection ◽  
Susceptible Population ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

The Zika virus (ZIKV) outbreak in French Polynesia, in 2013, and in Brazil, in 2015, was correlated with neurological complications, which comprised, among others, congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or gastrointestinal infectious diseases. Despite being relatively rare, the incidence rate of GBS rises with age, which makes GBS more frequent in the elderly, in whom it is also a more severe disease with slower recovery than in younger patients. Different forms of GBS have been described having diagnostic confirmation of a previous infection with the ZIKV virus. Although we do not have enough evidence that elderly people are a particularly susceptible population to developing GBS following ZIKV infection, this is plausible. We should consider this possibility, particularly taking into account that aging subjects are more susceptible to infections. In this context, a deeper understanding of how the immune system in the elderly functions in relation to ZIKV infection is necessary, as well as an understanding of what kind of alterations of the nervous system such an infection triggers in the elderly, beyond GBS. This will be relevant for better therapeutic interventions and for designing vaccine candidates that can be applied in an aging population, particularly those prone to develop ZIKV-induced autoimmunity.

scholarly journals Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: systematic review

2016 ◽  
Author(s):  
Fabienne Krauer ◽  
Maurane Riesen ◽  
Ludovic Reveiz ◽  
Olufemi T Oladapo ◽  
Ruth Martínez-Vega ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Virus Infection ◽  
Dose Response ◽  
Zika Virus ◽  
Guillain Barre Syndrome ◽  
Brain Abnormalities ◽  
Zika Virus Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

AbstractBackgroundThe World Health Organization stated in March 2016 that there was scientific consensus that the mosquito-borne Zika virus was a cause of the neurological disorder Guillain-Barré syndrome and of microcephaly and other congenital brain abnormalities, based on rapid evidence assessments. Decisions about causality require systematic assessment to guide public health actions. The objectives of this study were: to update and re-assess the evidence for causality through a rapid and systematic review about links between Zika virus infection and a) congenital brain abnormalities, including microcephaly, in the foetuses and offspring of pregnant women and b) Guillain-Barré syndrome in any population; and to describe the process and outcomes of an expert assessment of the evidence about causality.Methods and findingsThe study had three linked components. First, in February 2016, we developed a causality framework that defined questions about the relationship between Zika virus infection and each of the two clinical outcomes in 10 dimensions; temporality, biological plausibility, strength of association, alternative explanations, cessation, dose-response, animal experiments, analogy, specificity and consistency. Second, we did a systematic review (protocol number CRD42016036693). We searched multiple online sources up to May 30, 2016 to find studies that directly addressed either outcome and any causality dimension, used methods to expedite study selection, data extraction and quality assessment, and summarised evidence descriptively. Third, a multidisciplinary panel of experts assessed the review findings and reached consensus on causality. We found 1091 unique items up to May 30, 2016. For congenital brain abnormalities, including microcephaly, we included 72 items; for eight of 10 causality dimensions (all except dose-response relationship and specificity) we found that more than half the relevant studies supported a causal association with Zika virus infection. For Guillain-Barré syndrome, we included 36 items, of which more than half the relevant studies supported a causal association in seven of ten dimensions (all except dose-response relationship, specificity and animal experimental evidence). Articles identified non-systematically from May 30-July 29, 2016 strengthened the review findings. The expert panel concluded that: a) the most likely explanation of available evidence from outbreaks of Zika virus infection and clusters of microcephaly is that Zika virus infection during pregnancy is a cause of congenital brain abnormalities including 61 microcephaly; and b) the most likely explanation of available evidence from outbreaks of Zika virus infection and Guillain-Barré syndrome is that Zika virus infection is a trigger of Guillain-Barré syndrome. The expert panel recognised that Zika virus alone may not be sufficient to cause either congenital brain abnormalities or Guillain-Barré syndrome but agreed that the evidence was sufficient to recommend increased public health measures. Weaknesses are the limited assessment of the role of dengue virus and other possible co-factors, the small number of comparative epidemiological studies, and the difficulty in keeping the review up to date with the pace of publication of new research.ConclusionsRapid and systematic reviews with frequent updating and open dissemination are now needed, both for appraisal of the evidence about Zika virus infection and for the next public health threats that will emerge. This rapid systematic review found sufficient evidence to say that Zika virus is a cause of congenital abnormalities and is a trigger of Guillain-Barré situation.

scholarly journals Guillain-Barré syndrome associated with the Zika virus outbreak in Brazil

2016 ◽  
Vol 74 (3) ◽  
pp. 253-255 ◽  
Author(s):  
Lucas Masiêro Araujo ◽  
Maria Lucia Brito Ferreira ◽  
Osvaldo JM Nascimento
Keyword(s):  
Zika Virus ◽  
French Polynesia ◽  
Neurological Complications ◽  
Standard Test ◽  
Guillain Barre Syndrome ◽  
Zikv Infection ◽  
Resource Limited ◽  
Guillain Barré Syndrome ◽  
Large Outbreak ◽  
Guillain Barré

ABSTRACT Zika virus (ZIKV) is now considered an emerging flavivirosis, with a first large outbreak registered in the Yap Islands in 2007. In 2013, a new outbreak was reported in the French Polynesia, with associated cases of neurological complications including Guillain-Barré syndrome (GBS). The incidence of GBS has increased in Brazil since 2015, what is speculated to be secondary to the ZIKV infection outbreak. The gold-standard test for detection of acute ZIKV infection is the polymerase-chain reaction technique, an essay largely unavailable in Brazil. The diagnosis of GBS is feasible even in resource-limited areas using the criteria proposed by the GBS Classification Group, which is based solely on clinical grounds. Further understanding on the relationship of ZIKV with neurological complications is a research urgency.

scholarly journals Zika virus detection in urine from patients with Guillain-Barré syndrome on Martinique, January 2016

2016 ◽  
Vol 21 (9) ◽  
Author(s):  
Benoît Rozé ◽  
Fatiha Najioullah ◽  
Jean-Louis Fergé ◽  
Kossivi Apetse ◽  
Yannick Brouste ◽  
...  
Keyword(s):  
Symptom Onset ◽  
Zika Virus ◽  
Neurological Complication ◽  
Virus Detection ◽  
Guillain Barre Syndrome ◽  
Zikv Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

We report two cases of Guillain–Barré syndrome who had concomitant Zika virus viruria. This viruria persisted for longer than 15 days after symptom onset. The cases occurred on Martinique in January 2016, at the beginning of the Zika virus outbreak. Awareness of this possible neurological complication of ZikV infection is needed.

scholarly journals A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection

2019 ◽  
Vol 93 (16) ◽  
Author(s):  
Anna Dukhovny ◽  
Kevin Lamkiewicz ◽  
Qian Chen ◽  
Markus Fricke ◽  
Nabila Jabrane-Ferrat ◽  
...  
Keyword(s):  
Cell Death ◽  
Zika Virus ◽  
Neurological Complications ◽  
Host Factors ◽  
Guillain Barre Syndrome ◽  
Zikv Infection ◽  
A Genome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Crispr Activation

ABSTRACT Zika virus (ZIKV) is an arthropod-borne emerging pathogen causing febrile illness. ZIKV is associated Guillain-Barré syndrome and other neurological complications. Infection during pregnancy is associated with pregnancy complications and developmental and neurological abnormalities collectively defined as congenital Zika syndrome. There is still no vaccine or specific treatment for ZIKV infection. To identify host factors that can rescue cells from ZIKV infection, we used a genome-scale CRISPR activation screen. Our highly ranking hits included a short list of interferon-stimulated genes (ISGs) previously reported to have antiviral activity. Validation of the screen results highlighted interferon lambda 2 (IFN-λ2) and interferon alpha-inducible protein 6 (IFI6) as genes providing high levels of protection from ZIKV. Activation of these genes had an effect on an early stage in viral infection. In addition, infected cells expressing single guide RNAs (sgRNAs) for both of these genes displayed lower levels of cell death than did the controls. Furthermore, the identified genes were significantly induced in ZIKV-infected placenta explants. Thus, these results highlight a set of ISGs directly relevant for rescuing cells from ZIKV infection or its associated cell death and substantiate CRISPR activation screens as a tool to identify host factors impeding pathogen infection. IMPORTANCE Zika virus (ZIKV) is an emerging vector-borne pathogen causing a febrile disease. ZIKV infection might also trigger Guillain-Barré syndrome, neuropathy, and myelitis. Vertical transmission of ZIKV can cause fetus demise, stillbirth, or severe congenital abnormalities and neurological complications. There is no vaccine or specific antiviral treatment against ZIKV. We used a genome-wide CRISPR activation screen, where genes are activated from their native promoters to identify host cell factors that protect cells from ZIKV infection or associated cell death. The results provide a better understanding of key host factors that protect cells from ZIKV infection and might assist in identifying novel antiviral targets.

scholarly journals Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis

2018 ◽  
Vol 22 (2) ◽  
pp. 137-141 ◽  
Author(s):  
Ludovica Barbi ◽  
Antonio Victor Campos Coelho ◽  
Luiz Cláudio Arraes de Alencar ◽  
Sergio Crovella
Keyword(s):  
Systematic Review ◽  
Zika Virus ◽  
Meta Analysis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré
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