scholarly journals Cell death in the developing rat cerebellum following X-irradiation of 3 to 100 rad: A quantitative study.

1983 ◽  
Vol 24 (3) ◽  
pp. 259-269 ◽  
Author(s):  
MINORU INOUYE ◽  
YOSHIRO KAMEYAMA
1972 ◽  
Vol 19 (9) ◽  
pp. 2229-2232 ◽  
Author(s):  
T. Valcana ◽  
D. Hudson ◽  
P. S. Timiras

1984 ◽  
Vol 15 (2) ◽  
pp. 298-301 ◽  
Author(s):  
N.J. Cook ◽  
M. Dontenwill ◽  
A. Meyer ◽  
G. Vincendon ◽  
J.P. Zanetta

1974 ◽  
Vol 16 (3) ◽  
pp. 205-211 ◽  
Author(s):  
SETSUYA FUJITA ◽  
TAKANORI HATTORI ◽  
MASARU FUKUDA ◽  
TADAHISA KITAMURA

2016 ◽  
Vol 88 (suppl 1) ◽  
pp. 653-663 ◽  
Author(s):  
Dulce-Mariely Álvarez-Croda ◽  
Juan Santiago-García ◽  
Jesús S. Medel-Matus ◽  
Joel Martínez-Quiroz ◽  
Angel A. Puig-Lagunes ◽  
...  

The contribution of Interleukin-1β (IL-1β) to neuronal injury induced by status epilepticus (SE) in the immature brain remains unclear. The goal of this study was to determine the hippocampal expression of IL-1β and its type 1 receptor (IL-1RI) following SE induced by the lithium-pilocarpine model in fourteen-days-old rat pups; control animals were given an equal volume of saline instead of the convulsant. IL-1β and IL-1RI mRNA hippocampal levels were assessed by qRT-PCR 6 and 24 h after SE or control conditions. IL-1β and IL-1RI expression was detected in the dorsal hippocampus by immunohistochemical procedures; Fluoro-Jade B staining was carried out in parallel sections in order to detect neuronal cell death. IL-1β mRNA expression was increased 6 h following SE, but not at 24 h; however IL-1RI mRNA expression was unaffected when comparing with the control group. IL-1β and IL-1RI immunoreactivity was not detected in control animals. IL-1β and IL-1RI were expressed in the CA1 pyramidal layer, the dentate gyrus granular layer and the hilus 6 h after SE, whereas injured cells were detected 24 h following seizures. Early expression of IL-1β and IL-1RI in the hippocampus could be associated with SE-induced neuronal cell death mechanisms in the developing rat.


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