scholarly journals The Relationship of Intact Parathyroid Hormone and Ionised Calcium in Secondary Hyperparathyroidism among Hemodialysis Patients

2014 ◽  
Vol 2 (4) ◽  
pp. 75-78
Author(s):  
T Sudhakar ◽  
Sabitha Kandi ◽  
B venugopal ◽  
K. Bhagwan Reddy ◽  
K. V. Ramana
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Hemodialysis Patients ◽  
Intact Parathyroid Hormone ◽  
Ionised Calcium ◽  
Relationship Of ◽  
The Relationship

scholarly journals Study on the Relationship of 25-hydroxyvitamin D and Intact Parathyroid Hormone in Chinese Adults

2020 ◽  
Author(s):  
Yichun Hu ◽  
Siran Li ◽  
Zhen Liu ◽  
Lichen Yang ◽  
Xiaoguang Yang
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Intact Parathyroid Hormone ◽  
Chinese Adults ◽  
Serum Samples ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Relationship Of ◽  
The Relationship ◽  
Ipth Concentration

Abstract Background:Vitamin D plays an important role in bone health and other diseases, however, there is no consensus over the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration. Many studies consider that the 25(OH)D concerntration which maximally inhibit serum intact parathyroid hormone (iPTH) might be the optimal status for vitamin D sufficiency. This study was performed to study the relationship between 25(OH)D concentration and intact parathyroid hormone (iPTH) concentration in the Chinese non-clinical population aged 18-44y. Methods: The serum samples of adults aged 18-44 years old were selected from the established serum bank of Chinese Chronic Diseases and Nutrition Survey (CCDNS, 2015-2018). The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer, and the iPTH was determined by electronic chemiluminescence method. The relationship of 25(OH)D and iPTH were analyzed by correlation analysis, segmented linear regression and the confidence interval was determined by bootstrap method. Results: 623 serum samples (293 male, 330 female) of 25(OH)D concentration and iPTH concentration were analyzed. Significant higher 25(OH)D concentration was found in male than female. And the samples from the southern China had higher 25(OH)D concentration than those from the northern China. Samples from autumn had higher 25(OH)D concentration than those from spring and winter. The inversely relationship between 25(OH)D concentration and iPTH concentration was observed in both male and female. The concentration of 25(OH)D was 19.2 (10.1-27.2) ng/mL (P=0.02) when iPTH entered the plateau in women and no plateau for iPTH was found in men. Conclusions: The relationship between 25(OH)D and iPTH differs by sex among Chinese adults aged 18-44y. Further study is needed to evaluate the sex-specific ranges of optimal vitamin D. Trial registration: Not applicable. Keywords: 25-hydroxyvitamin D; parathyroid hormone; plateau; Chinese adults

scholarly journals Study on the Relationship of 25-hydroxyvitamin D and Intact Parathyroid Hormone in Chinese Young Adults

2020 ◽  
Author(s):  
Yichun Hu ◽  
Siran Li ◽  
Zhen Liu ◽  
Lichen Yang ◽  
Xiaoguang Yang
Keyword(s):  
Vitamin D ◽  
Young Adults ◽  
Parathyroid Hormone ◽  
Intact Parathyroid Hormone ◽  
Serum Samples ◽  
Hydroxyvitamin D ◽  
Chinese Young Adults ◽  
Relationship Of ◽  
The Relationship ◽  
Ipth Concentration

Abstract Background : Vitamin D plays an important role in bone health and other diseases, however, there is no consensus over the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration. Many studies defined a level of serum 25(OH)D at which serum intact parathyroid hormone (iPTH) levels decreased and reached a plateau might be the optimal status for vitamin D sufficiency. This study was performed to study the relationship between 25(OH)D concentration and intact parathyroid hormone (iPTH) concentration in the Chinese non-clinical young population aged 18-44y. Methods : The serum samples of young adults aged 18-44 years old were selected from the established serum bank of Chinese Chronic Diseases and Nutrition Survey (CCDNS, 2015-2018). The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer, and the iPTH was determined by electronic chemiluminescence method. The relationship of 25(OH)D and iPTH were analyzed by partial correlation analysis, and the threshold of 25(OH)D was analyzed by locally weighted scatter plot smoothing method after adjusting the iPTH by age, season of blood draw, BMI, waist, sex and latitude. Results : 623 serum samples (293 male, 330 female) of 25(OH)D concentration and iPTH concentration were analyzed. Significant higher 25(OH)D concentration was found in male than female. And the samples from the southern China had higher 25(OH)D concentration than those from the northern China. Samples from autumn had higher 25(OH)D concentration than those from spring and winter. The inversely relationship between 25(OH)D concentration and iPTH concentration was observed when the 25(OH)D was below 17.6 ng/mL for both sexes. The threshold for male was 16.2 ng/mL and it was 25.6 ng/mL for female. Conclusions : The threshold and the relationship between 25(OH)D and iPTH differs by sex among Chinese young adults aged 18-44y. Further study is needed to evaluate the sex-specific ranges of optimal vitamin D. Trial registration : Not applicable.

Relationship of predialytic intact parathyroid hormone on secondary hyperparathyroidism in chronic maintenance haemodialysis patients

Nephrology ◽  
2004 ◽  
Vol 9 (3) ◽  
pp. 161-166 ◽  
Author(s):  
SATOSHI ETOH ◽  
TOSHIAKI MURATA ◽  
YOSHIYUKI HASEGAWA ◽  
YOSHITO MIYAHARA ◽  
ATUNORI ISHIMURA ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Intact Parathyroid Hormone ◽  
Maintenance Haemodialysis ◽  
Relationship Of

scholarly journals Changes in 3-month mineral and bone disorder patterns were associated with all-cause mortality in prevalent hemodialysis patients with secondary hyperparathyroidism

2020 ◽  
Author(s):  
Chihiro Kato ◽  
Naohiko Fujii ◽  
Chisato Miyakoshi ◽  
Shinji Asada ◽  
Yoshihiro Onishi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Hemodialysis Patients ◽  
Lower Mortality ◽  
Intact Parathyroid Hormone ◽  
Mineral And Bone Disorder ◽  
High Category ◽  
Bone Disorder ◽  
All Cause Mortality ◽  
Changing Patterns

Abstract Background. There is limited evidence on the association between short-term changes in mineral and bone disorder parameters and survival in maintenance hemodialysis patients. Methods. We investigated the association between changing patterns of phosphorus, calcium and intact parathyroid hormone levels and all-cause mortality in hemodialysis patients with secondary hyperparathyroidism. Each parameter was divided into three categories (low [L], middle [M] and high [H]), and the changing patterns between two consecutive visits at 3-month intervals were categorized into nine groups (e.g., L-L and M-H). The middle category was defined as 4.0-7.0 mg/dL for phosphorous, 8.5-9.5 mg/dL for calcium and 200-500 pg/mL for intact parathyroid hormone. Adjusted incidence rates and rate ratios were analyzed by weighted Poisson regression models accounting for time-dependent exposures. Results. For phosphorus, shifts from low/high to middle category (L-M/H-M) were associated with a lower mortality compared with the L-L and H-H groups, whereas shifts from middle to low/high category (M-L/M-H) were associated with a higher mortality compared with the M-M group. For calcium, shifts from low/middle to high category (L-H/M-H) were associated with a higher mortality compared with the L-L and M-M groups, whereas shifts from high to middle category (H-M) were associated with a lower mortality compared with the H-H group. For intact parathyroid hormone, shifts from low to middle category (L-M) were associated with a lower mortality compared with the L-L group. Conclusions. Changes in the 3-month patterns of phosphorus and calcium toward the middle category were associated with lower mortality. Our study also suggests the importance of avoiding hypercalcemia.

scholarly journals Changes in 3-month mineral and bone disorder patterns were associated with all-cause mortality in prevalent hemodialysis patients with secondary hyperparathyroidism

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Chihiro Kato ◽  
Naohiko Fujii ◽  
Chisato Miyakoshi ◽  
Shinji Asada ◽  
Yoshihiro Onishi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Hemodialysis Patients ◽  
Lower Mortality ◽  
Intact Parathyroid Hormone ◽  
Mineral And Bone Disorder ◽  
High Category ◽  
Bone Disorder ◽  
All Cause Mortality ◽  
Changing Patterns

Abstract Background There is limited evidence on the association between short-term changes in mineral and bone disorder parameters and survival in maintenance hemodialysis patients. Methods We investigated the association between changing patterns of phosphorus, calcium and intact parathyroid hormone levels and all-cause mortality in hemodialysis patients with secondary hyperparathyroidism. Each parameter was divided into three categories (low [L], middle [M] and high [H]), and the changing patterns between two consecutive visits at 3-month intervals were categorized into nine groups (e.g., L-L and M-H). The middle category was defined as 4.0–7.0 mg/dL for phosphorous, 8.5–9.5 mg/dL for calcium and 200–500 pg/mL for intact parathyroid hormone. Adjusted incidence rates and rate ratios were analyzed by weighted Poisson regression models accounting for time-dependent exposures. Results For phosphorus, shifts from low/high to middle category (L-M/H-M) were associated with a lower mortality compared with the L-L and H–H groups, whereas shifts from middle to low/high category (M-L/M-H) were associated with a higher mortality compared with the M-M group. For calcium, shifts from low/middle to high category (L–H/M-H) were associated with a higher mortality compared with the L-L and M-M groups, whereas shifts from high to middle category (H-M) were associated with a lower mortality compared with the H–H group. For intact parathyroid hormone, shifts from low to middle category (L-M) were associated with a lower mortality compared with the L-L group. Conclusions Changes in the 3-month patterns of phosphorus and calcium toward the middle category were associated with lower mortality. Our study also suggests the importance of avoiding hypercalcemia.

scholarly journals Changes in 3-month mineral and bone disorder patterns were associated with all-cause mortality in prevalent hemodialysis patients with secondary hyperparathyroidism

2020 ◽  
Author(s):  
Chihiro Kato ◽  
Naohiko Fujii ◽  
Chisato Miyakoshi ◽  
Shinji Asada ◽  
Yoshihiro Onishi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Hemodialysis Patients ◽  
Lower Mortality ◽  
Intact Parathyroid Hormone ◽  
Mineral And Bone Disorder ◽  
High Category ◽  
Bone Disorder ◽  
All Cause Mortality ◽  
Changing Patterns

Abstract Background. There is limited evidence on the association between short-term changes in mineral and bone disorder parameters and survival in maintenance hemodialysis patients. Methods. We investigated the association between changing patterns of phosphorus, calcium and intact parathyroid hormone levels and all-cause mortality in hemodialysis patients with secondary hyperparathyroidism. Each parameter was divided into three categories (low [L], middle [M] and high [H]), and the changing patterns between two consecutive visits at 3-month intervals were categorized into nine groups (e.g., L-L and M-H). The middle category was defined as 4.0-7.0 mg/dL for phosphorous, 8.5-9.5 mg/dL for calcium and 200-500 pg/mL for intact parathyroid hormone. Adjusted incidence rates and rate ratios were analyzed by weighted Poisson regression models accounting for time-dependent exposures. Results. For phosphorus, shifts from low/high to middle category (L-M/H-M) were associated with a lower mortality compared with the L-L and H-H groups, whereas shifts from middle to low/high category (M-L/M-H) were associated with a higher mortality compared with the M-M group. For calcium, shifts from low/middle to high category (L-H/M-H) were associated with a higher mortality compared with the L-L and M-M groups, whereas shifts from high to middle category (H-M) were associated with a lower mortality compared with the H-H group. For intact parathyroid hormone, shifts from low to middle category (L-M) were associated with a lower mortality compared with the L-L group. Conclusions. Changes in the 3-month patterns of phosphorus and calcium toward the middle category were associated with lower mortality. Our study also suggests the importance of avoiding hypercalcemia.

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