Convenient Preparation and Quantification of 5,5′-Diferulic Acid

1999 ◽  
Vol 63 (2) ◽  
pp. 390-394 ◽  
Author(s):  
Hirotaka YAMAMOTO ◽  
Tsutomu HOSHINO ◽  
Takeo UCHIYAMA

Synthesis ◽  
2014 ◽  
Vol 46 (05) ◽  
pp. 596-599 ◽  
Author(s):  
Mohamed Eddaoudi ◽  
Łukasz Weseliński ◽  
Ryan Luebke


Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 930
Author(s):  
Rares I. Birsan ◽  
Peter Wilde ◽  
Keith W. Waldron ◽  
Dilip K. Rai

Cholinesterases, involved in acetylcholine catabolism in the central and peripheral nervous system, have been strongly linked with neurodegenerative diseases. Current therapeutic approaches using synthetic drugs present several side effects. Hence, there is an increasing research interest in naturally-occurring dietary polyphenols, which are also considered efficacious. Food processing by-products such as brewer’s spent grain (BSG) would be a potential bio-source of polyphenols. In this study, polyphenol-rich BSG extracts using 60% acetone and 0.75% NaOH solutions were generated, which were further subjected to liquid–liquid partitioning using various organic solvents. The water-partitioned fractions of the saponified extracts had the highest total polyphenol content (6.2 ± 2.8mgGAE/g dw) as determined by Folin–Ciocalteu reagent, while the LC-MS/MS showed ethyl acetate fraction with the highest phenolics (2.9 ± 0.3mg/g BSG dw). The best inhibitions of acetyl- (37.9 ± 2.9%) and butyryl- (53.6 ± 7.7%) cholinesterases were shown by the diethyl ether fraction of the saponified extract. This fraction contained the highest sum of quantified phenolics (99 ± 21.2µg/mg of extract), and with significant (p < 0.01) inhibitory contribution of decarboxylated-diferulic acid. Amongst the standards, caffeic acid presented the highest inhibition for both cholinesterases, 25.5 ± 0.2% for acetyl- and 52.3 ± 0.8% for butyryl-cholinesterase, respectively, whilst the blends insignificantly inhibited both cholinesterases. The results showed that polyphenol-rich BSG fractions have potentials as natural anti-cholinesterase agents.



1978 ◽  
Vol 9 (26) ◽  
Author(s):  
S. W. BALDWIN ◽  
M. T. CRIMMINS ◽  
V. I. CHEEK


1981 ◽  
Vol 12 (37) ◽  
Author(s):  
N. S. NUDELMAN ◽  
A. A. VITALE


1993 ◽  
Vol 12 (12) ◽  
pp. 4881-4886 ◽  
Author(s):  
Xianqi Kong ◽  
T. Bruce Grindley ◽  
Pradip K. Bakshi ◽  
T. Stanley Cameron


1976 ◽  
Vol 8 (2) ◽  
pp. 85-86 ◽  
Author(s):  
Mahesh Desai ◽  
Jeffrey W. H. Watthey ◽  
Marie Zuckerman


1976 ◽  
Vol 7 (11) ◽  
pp. no-no
Author(s):  
L. GRUBER ◽  
I. TOEMOESKOEZI ◽  
L. RADICS


ChemInform ◽  
2010 ◽  
Vol 30 (33) ◽  
pp. no-no
Author(s):  
Masanobu Yamamoto ◽  
Hiroyuki Yamazawa ◽  
Naoto Nakajima ◽  
Tetsu Ando


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